A5037810162- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Helicobacter pylori-related gastroenterology studies
- Neuroscience and Neural Engineering
- Pancreatic function and diabetes
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Advanced Chemical Sensor Technologies
- Bat Biology and Ecology Studies
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine Tumor Research Advances
- Polydiacetylene-based materials and applications
- Nerve injury and regeneration
- Erythrocyte Function and Pathophysiology
- Ion Channels and Receptors
- Biochemical Analysis and Sensing Techniques
- Advanced Sensor and Energy Harvesting Materials
- Supramolecular Self-Assembly in Materials
- Gastrointestinal motility and disorders
Max Planck Institute for Developmental Biology
2017-2020
University of Tübingen
2015-2020
University of Hohenheim
2012-2017
Czech Academy of Sciences, Institute of Physiology
2017
G cells in the antrum region of murine stomach produce gastrin, central hormone for controlling gastric activities. Secretion gastrin is induced mainly by protein breakdown products but also distensions wall. Although respond to fragments via distinct chemosensory receptor types, mechanism underlying cell activation upon distention entirely ambiguous. Mechanosensitive ion channels are considered as potential candidates such a task. Therefore, we explore possibility whether Piezo1, polymodal...
Histological analysis of the cochlea is required to understand physiological and pathological processes in inner ear. In past, many embedding techniques have been tested find an optimal protocol that gives both good morphological immunohistochemical results. Resins provide high quality cochlear morphology with reduced immunogenicity due higher polymerization temperature.We used Technovit 9100 New(®), a low temperature system based on methyl methacrylate, adult guinea pig mouse cochleae...
Cochlear implants are neuroprostheses that inserted into the inner ear to directly electrically stimulate auditory nerve, thus replacing lost cochlear receptors, hair cells. The reduction of gap between electrodes and nerve cells will contribute technological solutions simultaneously increasing frequency resolution, sound quality amplification signal. Recent findings indicate neurotrophins (NTs) such as brain derived neurotrophic factor (BDNF) neurite outgrowth by activating Trk receptors on...
Background: The spatial gap between cochlear implants (CIs) and the auditory nerve limits frequency selectivity as large populations of spiral ganglion neurons (SGNs) are electrically stimulated synchronously. To improve CI performance, a possible strategy is to promote neurite outgrowth toward CI, thereby allowing discrete stimulation small SGN subpopulations. Brain-derived neurotrophic factor (BDNF) effective stimulate from SGNs. Method: TrkB (tropomyosin receptor kinase B) agonists, BDNF,...
<p>Gastrin-secreting enteroendocrine cells (G cells) in the antrum play an important role regulation of gastric secretion, motility and mucosal cell proliferation. Recently we have uncovered existence two subpopulations G with pivotally different morphology a distinct localization antral invaginations; functional implications types are still elusive. In this study transgenic mouse line which EGFP is expressed under control gastrin promoter was used to elucidate distribution pattern...