A5049653321- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Polyomavirus and related diseases
- RNA Research and Splicing
- Salivary Gland Disorders and Functions
- Cutaneous lymphoproliferative disorders research
- Antimicrobial Peptides and Activities
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Oral and gingival health research
- Peptidase Inhibition and Analysis
- Nail Diseases and Treatments
- Fungal Infections and Studies
- Tendon Structure and Treatment
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2021-2024
University Medical Centre Mannheim
2022-2024
Heidelberg University
2021-2024
University Hospital Heidelberg
2021-2024
Abstract Small extracellular vesicles from saliva (SEVs) have high potential as biomarkers in Head and Neck cancer (HNC). However, there is no common consensus on the ideal method for their isolation. This study compared different ultracentrifugation (UC) methods (durations + /− additional purification) with size exclusion chromatography (SEC) investigated of SEVs diagnostic biological activity NK CD8 T cells. 19 HNC patients 8 healthy donors (HDs) were thoroughly characterized. Transmission...
Although checkpoint inhibitors (CPI) have recently extended the treatment options and improved clinical response of advanced stage head neck squamous cell carcinoma (HNSCC), success remains unpredictable. Programmed death ligand‑1 (PD‑L1) is a key player in immunotherapy. Tumor cells, exosomes derived therefrom, are carriers PD‑L1 efficiently suppress immune responses. The aim present study was to analyze influence established therapies on expression HNSCC lines their exosomes. lines,...
Head and Neck Cancers (HNCs) have highly immunosuppressive properties. Small extracellular vesicles (sEVs), including exosomes, nanosized mediators of intercellular communication in the blood, carry proteins effectively inhibit anti-tumor immune responses HNCs. This study evaluates markers on sEVs from 40 HNC patients at different disease stages 3- 6-month follow-up after surgery and/or chemoradiotherapy. As controls, normal donors (NDs) are examined. Immunoregulatory surface were detected...
Abstract Background In Head and neck cancer (HNC) angiogenesis is essential for tumor progression metastasis. Small extracellular vesicles (sEVs) from HNC cell lines alter endothelial (EC) functions towards a pro-angiogenic phenotype. However, the role of plasma sEVs retrieved patients in this process not clear so far. Methods Plasma were isolated on size exclusion chromatography columns 32 (early-stage UICC I/II: 8, advanced-stage III/IV: 24), 12 with no evident disease after therapy (NED)...
Introduction Salivary exosomes have high potential as non-invasive diagnostic biomarkers for Head and Neck cancer (HNC). In this study, we investigated the protein cargo functional impact of salivary from HNC patients healthy donors (HD).
Einleitung Speichelexosomen haben großes Potential nicht invasive diagnostische Biomarker für Kopf-Halstumore (HNC) zu werden. In dieser Studie wurde der Proteingehalt und die funktionellen Auswirkungen von HNC-Patienten gesunden Spendern (HDs) untersucht.
Einleitung Die Angiogenese spielt eine wichtige Rolle bei der Entstehung und Progression von Kopf-Hals-Tumoren (HNC). Während Exosomen aus HNC-Zelllinien Endothelzellen (ECs) umprogrammieren somit die fördern, ist Plasmaexosomen noch unklar. Material &
Einleitung Kopf-Hals-Karzinome (HNC) sind stark immunsuppressiv, was mitunter durch Exosomen vermittelt wird. Insbesondere von Tumoren-abstammende beeinträchtigen die T-Zellfunktionen, indem sie Immun-Checkpoint(IC)-Signalwege dysregulieren, zur Tumorprogression und Immunevasion führt. In dieser Studie wurden funktionellen Effekte der HNC-Patienten auf IC-Profile T-Zellen Wirkung IC-Inhibitoren untersucht.
Introduction Angiogenesis plays an important role in the carcinogenesis, promotion and progression of head neck cancer (HNC). While exosomes from HNC cell lines effectively reprogram endothelial cells (ECs) to promote angiogenesis, plasma is still unclear.
Introduction Head and neck carcinomas (HNCs) are highly immunosuppressive, which is partly mediated by exosomes. Specifically, tumor-derived exosomes impair T cell functions dysregulating immune checkpoint (IC) signaling pathways, leading to cancer progression tumor evasion. This study investigated the functional impact of from HNC patients on IC profiles cells their interference with inhibitors.
Introduction Angiogenesis is a key regulatory mechanism in the carcinogenesis of head and neck cancer (HNC). While exosomes derived from HNC cell lines (TEX) have shown to reprogram endothelial cells (ECs) thus promote angiogenesis, role plasma still remains unclear.
Introduction: Early diagnosis of primary and recurrent disease is still a challenge in head neck oncology. Advanced tumors are often resistant to oncologic therapies. This study analyzed exosomes from cancer (HNC) patients normal donors (ND) for stage-dependent differences.
Einleitung Die frühzeitige Diagnose eines Primärtumors oder Rezidivs stellt in der Kopf-Hals-Onkologie noch immer eine Herausforderung dar. Fortgeschrittene Tumore sprechen häufig nur schlecht auf onkologische Therapie an. Diese Studie untersucht Exosomen von Kopf-Hals-Tumor (HNC)-Patienten und gesunden Spendern (ND) ihre Stadien-abhängigen Unterschiede.