A5102778109- Pituitary Gland Disorders and Treatments
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Intracranial Aneurysms: Treatment and Complications
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Cardiovascular Health and Disease Prevention
- Cancer Cells and Metastasis
- Biochemical effects in animals
- Blood Pressure and Hypertension Studies
- Retinal Imaging and Analysis
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Diabetes Treatment and Management
- Mesenchymal stem cell research
- Adrenal and Paraganglionic Tumors
- Body Contouring and Surgery
- Adrenal Hormones and Disorders
- Muscle and Compartmental Disorders
- Angiogenesis and VEGF in Cancer
- TGF-β signaling in diseases
- Natural Antidiabetic Agents Studies
- Infectious Diseases and Mycology
- Neuroendocrine Tumor Research Advances
University Medical Centre Mannheim
2013-2024
Heidelberg University
2014-2024
University Hospital Heidelberg
2014-2024
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2020-2021
Universitäts HNO Klinik Mannheim
2019
University Medical Center
2014-2015
University Hospital and Clinics
2014-2015
Pituitary carcinomas are rare and neurosurgically challenging lesions, as they commonly relapse after surgical removal. Their prognosis is dismal due to their limited response radiotherapy chemotherapy. In recent studies, temozolomide was administered in very few patients with partial effects. We report a patient an ACTH-secreting pituitary carcinoma widespread intracranial, spinal systemic metastases despite repeated treatment, bilateral adrenalectomy, medical treatment radiotherapy....
Abstract Context Despite growing evidence that temozolomide (TMZ) therapy is effective for the treatment of aggressive pituitary tumors (APTs) or carcinomas (PCs), individual decisions remain challenging. Objective We therefore aimed to report on clinical characteristics leading initiation TMZ and add long-term effectiveness. Design subjects Retrospective survey in patients with APTs PCs. was initiated 47 (22 females) (n = 34) PCs 13). Mean age at diagnosis 45 ± 15 years. The...
Ipilimumab is besides the BRAF inhibitor vemurafenib first officially approved medical treatment for metastatic melanoma, which results in improved survival. leads to a release of CTLA4-mediated inhibition T-cell immunoreactions. Therefore, patients may also suffer from immune-related adverse events affecting different organs, are typically treated by high-dose corticosteroids. Ipilimumab-induced hypophysitis (iH) has been reported up 17% melanoma clinical trials. Here we present 5 with and...
Familial and sporadic GH-secreting pituitary adenomas are associated with mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene. Patients an AIP mutation (AIPmut) tend to have more aggressive tumors occurring at a younger age.The objective of study was investigate frequency AIPmut patients diagnosed 30 years age or younger.The German Acromegaly Registry database (1795 58 centers) screened for acromegaly (329 patients). Sixteen centers participated 91 consented...
Abstract Background Diabetes mellitus type 2 (DM2) is highly associated with increased risk for chronic kidney disease (CKD), end stage renal (ESRD) and cardiovascular morbidity. Epidemiological genetic studies generate hypotheses innovative strategies in DM2 management by unravelling novel mechanisms of diabetes complications, which essential future intervention trials. We have thus initiated the DIAbetes COhoRtE study (DIACORE). Methods DIACORE a prospective cohort aiming to recruit 6000...
Abstract Background In a pilot study, we evaluated the efficacy of two days oatmeal on insulin resistance and glucose metabolism found marked decrease requirements. The most important shortcoming that study was interventions were not isocaloric (diabetes adapted diet: 1500 kcal/d vs. 1100 kcal/d). To address these drawbacks designed OatMeal And Insulin Resistance (OMA-IR) study. Methods randomized, open label crossover dietary intervention with consecutive inclusion 15 patients uncontrolled...
Obesity causes increased morbidity and mortality from metabolic cardiovascular disease (CVD). We investigated the effect of bariatric surgery on endothelial dysfunction (ED) in retinal vessels as a marker risk patients with obesity WHO III. Thirty consecutive (19/11, w/m) were evaluated by anthropometry, lipid profile, oral glucose tolerance test before after (Mannheim Study (MOS); NCT 00770276). Risk stratification was performed presence syndrome (MetS) according to ATP‐III (adult treatment...
Objective: Neuropsychological sequelae are common after aneurysmal subarachnoid hemorrhage (aSAH) and may be associated with or caused by supposed hypothalamic-pituitary dysfunction. We evaluated the incidence of neuro-endocrine neuropsychological deficits aSAH their interrelations in a standardized manner.
To analyze the performance of 1 mg dexamethasone suppression test (DST) in patients with obesity. Special attention was paid to influence interfering medication on DST.In this prospective cohort study (Mannheim Obesity Study), obesity were evaluated before bariatric surgery. For evaluation hypercortisolism, a dexamethasone-suppression all subjects performed. Medication assessed for possible interference.Two hundred seventy-eight mean age 42.3 years (68.8% women) and BMI 47.9 ± 8.4 kg/m(2)...
Considering that the homozygous CNDP1 (CTG) 5 genotype affords protection against diabetic nephropathy (DN) in female patients with type 2 diabetes, this study assessed if association remains gender-specific when applying clinical inclusion criteria (CIC-DN) or biopsy proof (BP-DN). Additionally, it prevalence of protective changes diabetes duration and time on hemodialysis occurs serum carnosinase (CN-1) activity. Whereas distribution no-DN CIC-DN was comparable, a lower frequency found...
Abstract Objective Pituitary apoplexy is a serious medical complication of pre-existing pituitary adenoma characterized by variety clinical symptoms ranging from mild headache to neurologically impaired and finally comatose patients. Management options are surgery or conservative treatment (e. g., with dexamethasone). Surgery commonly performed in case severe acute neurological visual symptoms. However, prospective studies demonstrating benefit over terms visual, even endocrine outcomes...
Abstract Background Beta-glucans are effective in binding bile acids (BA) thereby lowering cholesterol concentration. This might contribute to the beneficial effects of consumption β-glucan-rich foods like oatmeal on glucose homeostasis. Objective We measured BA serum concentrations patients with uncontrolled type 2 diabetes (T2DM) investigate effect two days treatment concentration as compared a conventional T2DM-adapted diet. Methods The OatMeal And Insulin Resistance study was performed...
Introduction Patients with diabetes mellitus type 2 (DM2) are at high risk for micro- and macrovascular disease. Here, we explore the degree of traditional factor control in baseline visit a cohort DM2 outpatients. Methods DIACORE (DIAbetes COhoRtE) is prospective study 3000 adult present results from visit. Sociodemographic anthropometric variables, cardiovascular factors, comorbidities medication were assessed by interview medical exams. Serum-creatinine based estimated glomerular...
Kidney transplant recipients are at increased risk of SARS-CoV-2 infection and a more severe course COVID-19.We conducted quantitative serologic testing antibodies specific for the wild type Omicron variant concern before after third-dose vaccination, either mRNA-1273 (Moderna) or BNT162b2 (Pfizer-BioNTech) in cohort 103 stable kidney (median [range] age, 58 [22-84] y, 57 men [55.3%]).Third-dose vaccination seroconversion rate from 57.3% to 71.8%. However, despite marked rise antibody...
Tularemia is a rare disease but shows an approximately 10-fold increase in reported cases over the last 15 years Germany. Clinical symptoms of acute tularemia infection are various, which often delays diagnosis. This case report gives overview clinical manifestations and importance interdisciplinary work to shorten time from onset effective treatment with Francisella tularensis. Since some life-threatening, early diagnosis vital. serves as reminder that diseases need be considered cervical...
Objective: With the pandemic of obesity identification individuals with hypercortisolism gets more difficult. We analyzed performance 1 mg dexamethasone suppression test (DST) in patients a clinical setting. Design and method: conducted prospective cohort study (MOS, NCT00770276). Patients presented our outpatient department for metabolic cardiovascular evaluation. After obtaining medical history were analysed anthropometry, metabolism, risk factors. For evaluation we performed...
Anhand früherer Ergebnisse konnten wir und andere Arbeitsgruppen zeigen, dass die molekulare Achse zwischen SDF1alpha CXCR4 eine entscheidende Rolle bei den Interaktionen potentiellen Tumorstammzellen (CSC) ihrer supportiven Nische spielen könnte. Unser derzeitiger Fokus liegt auf der Evaluation passender Methoden, um Zell-Zell-Interaktionen in Tumorstammzellnische von Plattenepithelkarzinomen Kopf-Hals-Region (HNSCC) vitro zu untersuchen.