A5082151908- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Growth Hormone and Insulin-like Growth Factors
- Ophthalmology and Eye Disorders
- Adrenal and Paraganglionic Tumors
- Parathyroid Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Bone health and treatments
- Neuroendocrine Tumor Research Advances
- Diet and metabolism studies
- Neuroblastoma Research and Treatments
- Blood disorders and treatments
- Neuroscience of respiration and sleep
- Diabetes and associated disorders
- Radiopharmaceutical Chemistry and Applications
- Restraint-Related Deaths
- Urticaria and Related Conditions
- Ion channel regulation and function
- Hepatitis Viruses Studies and Epidemiology
- Bone Tumor Diagnosis and Treatments
- Cutaneous lymphoproliferative disorders research
- Congenital Diaphragmatic Hernia Studies
- Cancer-related Molecular Pathways
Heinrich Heine University Düsseldorf
1987-2022
Düsseldorf University Hospital
1989-2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2012-2015
Endokrinologikum
2004-2011
Universitätsklinikum Würzburg
2010
Praxis für Humangenetik
2009
Heidelberg University
1976-2008
Praxis
1999
Aalborg University Hospital
1998
University Hospital Ulm
1996
One hundred and eighty-one families with multiple endocrine neoplasia type 2A (MEN-2A) or familial medullary thyroid carcinoma (FMTC) have been investigated for mutations in the ret protooncogene Germany. In 8 FMTC MEN-2A, no mutation could be detected cysteine-rich domain encoded exons 10 11 of protooncogene. DNA sequencing additional (no. 13–15) revealed rare noncysteine 3 (codons 631, 768, 844). contrast to these events, heterozygous missense exon 13, codons 790 791, were found 5 (4 MTC...
Journal Article Guidelines for TSH-receptor antibody measurements in pregnancy: results of an evidence-based symposium organized by the European Thyroid Association Get access P Laurberg, Laurberg Departments Endocrinology and Internal Medicine, Aalborg Hospital, Aalborg, Denmark Correspondence should be addressed to Department DK 9000 Search other works this author on: Oxford Academic Google Scholar B Nygaard, Nygaard Herlev Copenhagen, DenmarkDepartments D Glinoer, Glinoer University...
Ultrasound diagnosis of thyroid nodules has greatly increased their detection rate. Their risk for malignancy is estimated between 7 and 15% in data from specialized centers which are used guidelines recommendations. This high rate causes considerable anxiety to patients upon first diagnosis. Here, we retrospectively analyzed the sonographically diagnosed larger than 1 cm a primary/secondary care center when long-term longitudinal follow-up was included.In study, 17,592 were with nodule cm,...
Serum calcitonin (CT) has become a very specific and sensitive marker for human medullary thyroid carcinoma (MTC), neuroendocrine tumor affecting about 1 % of patients with nodular disease. MTC is characterized by early micrometastasis lack curative non-surgical treatment, so that diagnosis desirable. Based on systematic review scientific evidence, we propose multidisciplinary consensus recommendations the clinical use CT in goiter. To exclude MTC, serum should be determined disease, using...
Acromegaly is a rare disease with significant morbidity and increased mortality. Epidemiological data about therapeutic outcome under 'real life' conditions are scarce.To describe biochemical long-term of acromegaly patients in Germany.Retrospective analysis from 1344 followed 42 centers the German Register. Patients' were collected 8.6 (range 0-52.6) years after diagnosis. Controlled was defined by an IGF1 within center-specific reference range.Nine hundred seventeen showed normalized (157...
Nodular goiter is common worldwide, but there still debate over the medical treatment.The objective of study was measurement effect a treatment with (nonsuppressive) T(4), iodine, or combination both compared placebo on volume thyroid nodules and thyroid.This multicenter, randomized, double-blind trial in patients nodular Germany [LISA (Levothyroxin und Iodid der Strumatherapie Als Mono-oder Kombinationstherapie) trial].The conducted outpatient clinics university hospitals regional private...
Acromegaly is a rare disease characterized by high serum levels of GH and IGF-1. Animal studies have demonstrated links between these hormones cancer, but data regarding cancer incidence among acromegaly patients are inconsistent. Moreover, therapy options changed considerably since many the aforementioned were collected.The objective was to determine whether overall site-specific comparable that general population.Data from German Registry for 446 (6656 person-years diagnosis) treated in...
Abstract Reoperation was performed in 110 of 185 patients with a differentiated thyroid carcinoma. In 25 (23 per cent) the indication for reintervention large remnant and other 85 (77 persistent or recurrent cancer suspected. 32 (29 undergoing reoperation no evidence tissue found. Tumour 33 (30 resectable. Of 45 (41 residual tumour after operation 24 showed only occult carcinoma raised serum thyroglobulin level. Eight 21 macroscopically died from disease during mean follow-up 2·3 years. 13...
Summary Objective We evaluated the German Acromegaly Register for clinical variables associated with initial biochemical activity of patients acromegaly. Design Retrospective analysis data in registry. Patients A total 1485 acromegaly (males 45·6%, females 54·4%) were treated 42 endocrine centres until November 2005. Linear regression models used to estimate influence various parameters on activity. Results Male significantly younger at time diagnosis than female (41 vs. 47 years, P <...
Familial and sporadic GH-secreting pituitary adenomas are associated with mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene. Patients an AIP mutation (AIPmut) tend to have more aggressive tumors occurring at a younger age.The objective of study was investigate frequency AIPmut patients diagnosed 30 years age or younger.The German Acromegaly Registry database (1795 58 centers) screened for acromegaly (329 patients). Sixteen centers participated 91 consented...
Disease control is a prime target in acromegaly treatment. This should be achievable the vast majority of patients by available treatment options. For unknown reasons, however, significant number do not achieve disease control.To investigate reasons for failure to long-standing acromegaly.Survey based on German Acromegaly Registry database (1755 57 centres). Questionnaires were sent 47 centres treating 178 with elevated markers (IGF1 and GH) at last documented visit out 1528 diagnosis dated...
Abstract. In 68 patients with proved metastases of differentiated thyroid carcinoma the comparative value 131 I whole body scan and plasma Tg measurements in establishing diagnosis metastasis or recurrence was analyzed retrospectively. At time primary therapy most were diagnosed by post-therapy (78%). Eight 9 scintigraphic negative indicated elevated levels (> 10 ng/ml). Twenty-four 28 recurrences after a disease free interval 2 mCi scan, 18 these positive. Of 4 positive uptake all...