A5067260263- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Adrenal Hormones and Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine Tumor Research Advances
- Atrial Fibrillation Management and Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Chromatin Remodeling and Cancer
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- Thyroid and Parathyroid Surgery
- Head and Neck Surgical Oncology
- Myasthenia Gravis and Thymoma
- Genetic factors in colorectal cancer
- Brucella: diagnosis, epidemiology, treatment
- Medieval Philosophy and Theology
- Ophthalmology and Eye Disorders
- Melanoma and MAPK Pathways
Johannes Wesling Klinikum Minden
2015-2024
Ruhr University Bochum
2017-2023
University Hospitals of the Ruhr-University of Bochum
2018-2021
Helios Dr. Horst Schmidt Kliniken Wiesbaden
2003-2006
University Medical Center Hamburg-Eppendorf
1995-2003
Universität Hamburg
1992-2003
Marienkrankenhaus Hamburg
2001
KRH Klinikum Nordstadt
1993-1998
Neurological Surgery
1998
Eppendorf (Germany)
1994-1996
Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate reversal and resumption strategies by evaluating incidences of haemorrhagic thromboembolic complications, thereby defining an optimal time-window when restart therapeutic (TA) MHV ICH.We pooled individual patient-data (n = 2504) from a nationwide multicentre cohort-study (RETRACE, conducted at 22...
Gain-of-function somatic mutations in the ubiquitin specific protease 8 (USP8) gene have recently been reported as a cause of pituitary adenomas Cushing disease. Molecular diagnostic testing tumor tissue may aid diagnosis specimens obtained through therapeutic transsphenoidal surgery; however, for small tumors, availability fresh is limited, and contamination with normal frequent. We performed molecular DNA isolated from single formalin-fixed paraffin-embedded (FFPE) sections 42 patients...
Abstract Context Despite growing evidence that temozolomide (TMZ) therapy is effective for the treatment of aggressive pituitary tumors (APTs) or carcinomas (PCs), individual decisions remain challenging. Objective We therefore aimed to report on clinical characteristics leading initiation TMZ and add long-term effectiveness. Design subjects Retrospective survey in patients with APTs PCs. was initiated 47 (22 females) (n = 34) PCs 13). Mean age at diagnosis 45 ± 15 years. The...
If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated.To describe fractionated (FRT) stereotactic radiosurgery (SRS) regarding excess IGF-1 pituitary function.A retrospective analysis 352 patients (4126 patient-years) from the German Acromegaly Registry was performed. Follow-up 1.0-45.1 years after radiotherapy. Therapeutic success defined low or normal according to center-specific reference ranges without (= remission) on controlled...
After transnasal operations in Cushing's syndrome persisting hypercortisolism either due to negative pituitary exploration or subtotal tumor removal, and recurrence of the disease after successful surgery still are challenging. We report on therapeutic failures among 310 consecutive patients who underwent primary transsphenoidal microsurgery for disease. In 287 an ACTH-producing adenoma could be detected (finding rate: 92.6%). 264 cases remission attained (remission rate with 92.0%, whole...
Abstract Context Craniopharyngioma is a rare neoplastic entity of the central nervous system. Childhood-onset craniopharyngioma subject frequent research whereas information on adult-onset scarce. Objective The objective this study was to examine level daily impairment in adult patients suffering from craniopharyngioma. Design Noninterventional patient registry indexed as PV4842 with local ethics committee. Setting set hospitalized and ambulatory setting. Patients 148 were recruited 8...
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor. High infiltration rates and poor therapy responses make it deadliest glioma. The tumor metabolism known to differ from normal one influenced through various factors which can lead longer survival. Metabolites are small molecules (< 1500 Da) that display metabolic pathways in tissue. To determine alterations between peritumoral tissue human GBMs, mass spectrometry imaging (MSI) was performed on thin sections 25...
Transnasal adenomectomy is the treatment of choice for Cushing's disease. We review diagnostic peculiarities, specific surgical problems, and outcome children adolescents with disease.We report on our series 55 consecutive (range, 4.2-18.9 yr [mean age, 14.4 yr]; female:male = 1.1:1.0; mean follow-up, 54.5 +/- 38.6 mo [standard deviation]) disease whom we performed surgery since 1980. The indication transsphenoidal based endocrinological parameters not neuroradiological findings.Detection...
Background and Purpose- Given inconclusive studies, it is debated whether clinical imaging characteristics, as well functional outcome, differ among patients with intracerebral hemorrhage (ICH) related to vitamin K antagonists (VKA) versus non-vitamin antagonist (NOAC)-related ICH. Notably, characteristics according different NOAC agents dosages are not established. Methods- Multicenter observational cohort study integrating individual patient data of 1328 oral anticoagulation-associated...
Fragestellung: Der unmittelbar nach Tumorentfernung stattfindende Hormonabfall von ACTH oder anderer POMC-Metabolite lässt keine Aussage hinsichtlich der Radikalität Tumorexstirpation eines ACTH-sezernierenden Hypophysenadenoms bei Morbus Cushing zu. Dennoch sollte Hypophysenchirurg in Lage sein, so früh wie möglich das operative Ergebnis zu beurteilen, um gegebenenfalls eine frühe Reoperation planen können. Zur Zeit wird postoperative Abfall des Kortisols den subnormalen Bereich als...
Objective To determine the occurrence of intracranial haemorrhagic complications (IHC) on heparin prophylaxis (low-dose subcutaneous heparin, LDSH) in primary spontaneous intracerebral haemorrhage (ICH) (not oral anticoagulation-associated ICH, non-OAC-ICH), vitamin K antagonist (VKA)-associated ICH and non-vitamin anticoagulant (NOAC)-associated ICH. Methods Retrospective cohort study (RETRACE) 22 participating centres prospective single-centre with 1702 patients VKA-associated or...
There is considerable controversy as to which of the 2 operating modalities (microsurgical or endoscopic transnasal surgery) currently used resect pituitary adenomas (PAs) safest and most effective intervention. We compared rates clinical outcomes patients with PAs who underwent resection by either microsurgical surgery.To independently assess each modality type, we sought isolate microscopic PA surgeries a 1:1 tight-caliper (0.01) propensity score-matched analysis using multicenter,...
OBJECTIVE: Transnasal adenomectomy is the treatment of choice for Cushing's disease. We review diagnostic peculiarities, specific surgical problems, and outcome children adolescents with METHODS: report on our series 55 consecutive (range, 4.2-18.9 yr [mean age, 14.4 yr]; female:male = 1.1:1.0; mean follow-up, 54.5± 38.6 mo [standard deviation]) disease whom we performed surgery since 1980. The indication transsphenoidal based endocrinological parameters not neuroradiological findings....
Because of the common belief that there is an increase in surgical risk and morbidity involved therapy elderly patients with acromegaly, physicians tend to either neglect altogether or choose radiation combined medical treatment. In consideration expected increasing number resulting from social structure change coming years, we decided investigate outcome 15 acromegaly (13 women 2 men) older than 64 years (mean, 68.3 yr) at time surgery form a retrospective study. Medical treatment using...
Localization of microadenomas in Cushing's disease may be difficult as up to 45% patients sellar MRI fails detect a pituitary tumor. Intraoperative transsphenoidal ultrasound identify hyperechoic structures. We report on the first 18 consecutive cases with intraoperative use new device for direct contact high-frequency-ultrasound disease.18 (14 female, 4 male, age 24-71 years) typical endocrinological findings were included study. One macroadenoma and 13 suspected or identified...
Multiple tumorous lesions in one pituitary gland are rare and mostly described case reports. Their incidences combinations defined larger collectives. Therefore, we analyzed our large collection for double tumors of tumors, cysts, inflammation.The German Registry Pituitary Tumors, including cases from 1990 to 2018, served as the database. Our comprises a total 16,283 up until end 2018. Of these cases, 12,673 originated surgical 3,610 autopsy material. All specimens were fixed formalin...