A5011761920- Acute Ischemic Stroke Management
- Botulinum Toxin and Related Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Stroke Rehabilitation and Recovery
- Infectious Encephalopathies and Encephalitis
- Palliative Care and End-of-Life Issues
- Sympathectomy and Hyperhidrosis Treatments
- Neurological and metabolic disorders
- Clinical practice guidelines implementation
- Alcoholism and Thiamine Deficiency
- Healthcare Decision-Making and Restraints
- Cardiac Arrest and Resuscitation
- Biomedical and Chemical Research
- Ethics in medical practice
- Neurological Disorders and Treatments
- Epilepsy research and treatment
- Cerebrospinal fluid and hydrocephalus
- Bacterial Infections and Vaccines
- Medical Practices and Rehabilitation
- Hereditary Neurological Disorders
- Atrial Fibrillation Management and Outcomes
- Neurology and Historical Studies
Nuremberg Hospital
2013-2022
Paracelsus Medizinische Privatuniversität
2013-2022
Deutsche Gesellschaft für Neurologie
2021
Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
2021
Rhythm (United states)
2020
Community Hospital
2018-2019
Medical University of Vienna
2015-2017
Klinikum Arnsberg
2007
Friedrich-Alexander-Universität Erlangen-Nürnberg
1996-2005
Georg Simon Ohm University of Applied Sciences Nuremberg
2005
<h3>Importance</h3> Although use of oral anticoagulants (OACs) is increasing, there a substantial lack data on how to treat OAC-associated intracerebral hemorrhage (ICH). <h3>Objective</h3> To assess the association anticoagulation reversal and blood pressure (BP) with hematoma enlargement effects OAC resumption. <h3>Design, Setting, Participants</h3> Retrospective cohort study at 19 German tertiary care centers (2006-2012) including 1176 individuals for analysis long-term functional...
Objective. To study the efficacy and safety of botulinum toxin type A (BtxA) in treatment upper limb muscle spasticity, caused by stroke. Methods. This was a randomized, controlled trial. Patients received either placebo injections or total 1000 IU BtxA (Dysport) into five muscles affected arm. Muscle tone assessed using Modified Ashworth Scale (MAS). Other outcome measures were change joint range motion (ROM), Barthel index, pain score, goal attainment subjective evaluation benefit patients...
Food-borne botulism probably has accompanied mankind since its beginning. However, we have only few historical sources and documents on food poisoning before the 19th century. Some ancient dietary laws taboos may reflect some knowledge about life-threatening consumption of poisoned food. One example such a taboo is 10th century edict Emperor Leo VI Byzantium in which manufacturing blood sausages was forbidden. case reports intoxications with Atropa belladonna described patients food-borne...
Objective To investigate parameters associated with hematoma enlargement in non–vitamin K antagonist oral anticoagulant (NOAC)‐related intracerebral hemorrhage (ICH). Methods This retrospective cohort study includes individual patient data for 190 patients NOAC‐associated ICH over a 5‐year period (2011–2015) at 19 departments of neurology across Germany. Primary outcome was the association prothrombin complex concentrate (PCC) administration enlargement. Subanalyses were calculated blood...
Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate reversal and resumption strategies by evaluating incidences of haemorrhagic thromboembolic complications, thereby defining an optimal time-window when restart therapeutic (TA) MHV ICH.We pooled individual patient-data (n = 2504) from a nationwide multicentre cohort-study (RETRACE, conducted at 22...
In recent years, the molecular mode of action neurotoxins produced by different strains Clostridium botulinum has been successfully elucidated.1,2 Simultaneously, toxin type A proved to be effective and safe in treatment conditions caused focal contractions skeletal muscles, such as strabismus, hemifacial spasm, dystonias, spasticity, some autonomic disorders.3-11 Therapeutic chemodenervation with was pioneered Alan B. Scott 1973 monkey experiments10 1980 human applications.11 The first...
Cervical dystonia is a disabling basal ganglia disorder characterized by an involuntary head deviation to one side. A typical but also mysterious feature the impressive improvement of muscle spasms and posture application sensory facial stimulus (sensory trick). Here, we report effect trick on cortical activation patterns in 7 patients with cervical using H215O positron emission tomography. The stimulus, resulting near-neutral position, led increased mainly superior inferior parietal lobule...
Toxische und metabolische Enzephalopathien umfassen ein breites Spektrum an akuten oder chronischen sekundären Störungen der Gehirnfunktion aufgrund von schädigenden "Noxen" entweder durch endogene Organ- Stoffwechseldysfunktionen Zufuhr bzw. Einwirkung außen. Dabei kann die Enzephalopathie führende erste Manifestation Dysfunktion darstellen. Die Leitsymptome sind unspezifisch.
Abstract Background The impact of direct oral anticoagulants (DOAC) on haematoma size after intracerebral haemorrhage (ICH) compared to no-anticoagulation is controversial and prospective data are lacking. Methods investigator-initiated, multicentre, RASUNOA-prime study enrolled patients with non-traumatic ICH atrial fibrillation while a DOAC, vitamin K antagonist (VKA) or no anticoagulation (non-OAC). Neuroimaging was reviewed centrally blinded group allocation. Primary endpoint expansion...
In the last 10 years, stroke has become a medical emergency. Subsequently, early recognition of symptoms and rapid activation system are essential. We sought to investigate what witnesses or victims an acute syndrome recognize report in actual situation.We analyzed recordings all patients admitted our unit via Emergency Medical System (EMS) dispatch center Nuremberg within 1 year. With structured evaluation form, calls were screened for reported any diagnosis other facts mentioned...
The majority of stroke patients are treated in local general hospitals. Despite this fact, little is known about care these institutions. We sought to investigate the status quo acute management nonspecialized facilities with limited equipment and resources.Four hospitals located smaller cities a rural area Germany participated study. 4 were similar structure technical equipment; none had CT scanner in-house. reviewed medical records every patient hospitalized 1 within period 8 weeks year.We...
It remains to be determined whether the benefits of botulinum toxin type A (BoNT-A) on cervical dystonia (CD) motor symptoms extend improvements in patient's quality life (QoL). This analysis a large, multicentre study was conducted with aim investigating changes QoL and functioning among de novo patients receiving 500 U BoNT-A (abobotulinumtoxinA; Dysport) for treatment two most frequent forms CD, predominantly torticollis laterocollis.A prospective, open-label Dysport (500 U; Ipsen...
The intention of this observational study is to show the significant impact comorbidities and smoking on outcome in aneurysmal subarachnoid hemorrhage (SAH). During 203 cases treatment ruptured intracranial aneurysms were analyzed. We examined classified prospectively 12 month according modified Rankin Scale (mRS) considering retrospectively a history investigated occurrence early delayed cerebral ischemia between 2012 2017. Using logistic regression methods, we revealed (odds ratio 0.21; p...
Background and Purpose- Given inconclusive studies, it is debated whether clinical imaging characteristics, as well functional outcome, differ among patients with intracerebral hemorrhage (ICH) related to vitamin K antagonists (VKA) versus non-vitamin antagonist (NOAC)-related ICH. Notably, characteristics according different NOAC agents dosages are not established. Methods- Multicenter observational cohort study integrating individual patient data of 1328 oral anticoagulation-associated...
Objective To determine the occurrence of intracranial haemorrhagic complications (IHC) on heparin prophylaxis (low-dose subcutaneous heparin, LDSH) in primary spontaneous intracerebral haemorrhage (ICH) (not oral anticoagulation-associated ICH, non-OAC-ICH), vitamin K antagonist (VKA)-associated ICH and non-vitamin anticoagulant (NOAC)-associated ICH. Methods Retrospective cohort study (RETRACE) 22 participating centres prospective single-centre with 1702 patients VKA-associated or...
Abstract In this observational study, we analysed a cohort of 164 subarachnoid haemorrhage survivors (until discharge from intensive care) with the aim to detect factors that influence length stay (LOS) in care multiple linear regression methods. Moreover, binary logistic methods were used examine whether time is predictor outcome after 1 year. The clinical 1-year was measured prospectively 12-month follow-up by telephone interview and categorised modified Rankin Scale (mRS). Patients who...