A5002484568- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Ischemic Stroke Management
- EEG and Brain-Computer Interfaces
- Glycogen Storage Diseases and Myoclonus
- Heart Failure Treatment and Management
- RNA regulation and disease
- Thermal Regulation in Medicine
- Neurological disorders and treatments
- Influenza Virus Research Studies
- Respiratory and Cough-Related Research
- Autoimmune Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Family and Patient Care in Intensive Care Units
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Neurological and metabolic disorders
- Genetics and Neurodevelopmental Disorders
- S100 Proteins and Annexins
- Respiratory Support and Mechanisms
- Diet and metabolism studies
- Cytomegalovirus and herpesvirus research
Universitätsmedizin Greifswald
2014-2025
Klinik und Poliklinik für Neurologie
2022
Klinik Hirslanden
2020
Universität Greifswald
2015-2017
Abstract Background Assessment of quality life (QoL) has become an important indicator for chronic neurological diseases. While these conditions often limit personal independence and autonomy, they are also associated with treatment-related problems reduced expectancy. Epilepsy a tremendous impact on the QoL patients their families, which is underestimated by practitioners. The aim this work was to identify relevant factors affecting in adults epilepsy. Methods This cross-sectional,...
Seizure clusters, prolonged seizures, and status epilepticus are life-threatening neurological emergencies leading to irreversible neuronal damage. Benzodiazepines current evidence-based rescue therapy options; however, recent investigations indicated the prescription of mainly unsuitable benzodiazepines inappropriate use medication.
Abstract Background The impact of direct oral anticoagulants (DOAC) on haematoma size after intracerebral haemorrhage (ICH) compared to no-anticoagulation is controversial and prospective data are lacking. Methods investigator-initiated, multicentre, RASUNOA-prime study enrolled patients with non-traumatic ICH atrial fibrillation while a DOAC, vitamin K antagonist (VKA) or no anticoagulation (non-OAC). Neuroimaging was reviewed centrally blinded group allocation. Primary endpoint expansion...
In randomised controlled trials, adjunctive cenobamate (CNB) has been shown to reduce seizure frequency in patients with drug-resistant focal epilepsy. Studies conducted real-world settings provide valuable complementary data further characterise the drug's profile. To assess efficacy, retention and tolerability of (CNB), identify factors that might predict these outcomes clinical treatment epilepsies. This multicentre, retrospective cohort study included all who began CNB between October...
Background and Purpose— Stroke-induced immune alterations predispose patients to infections. Although the relationship between stroke adaptive system has been investigated in detail, date it is unknown whether innate system, which forms first line of antibacterial defense, also impaired with stroke. Therefore, we chemotaxis, phagocytosis, oxidative burst, degranulation defensins, NETosis monocytes neutrophil granulocytes are altered compared controls. Methods— Sixty-three having acute...
<h3>BACKGROUND AND PURPOSE:</h3> Detailed insight into the composition of thrombi retrieved from patients with ischemic stroke by mechanical thrombectomy might improve pathophysiologic understanding and therapy. Thus, this study searched for links between histologic thrombus subtypes results. <h3>MATERIALS METHODS:</h3> Thrombi 85 who had undergone acute December 2016 March 2018 were studied retrospectively. examined histologically. Preinterventional imaging features, subtypes,...
Summary Objective The increasing incidence of new‐onset seizures with age is well known. Often, the etiology cannot be clarified. In present study, patients unprovoked late‐onset and without known neoplasm, who might have had paraneoplastic encephalitis, were investigated for a potentially underlying autoimmunity. Methods Sixty‐six consecutive (36 women; aged ≥55 years) after having at least one seizure or ≤6 months prospectively identified over period 4.75 years. All tested serum...
Multiple structural white matter abnormalities have been described in patients with juvenile myoclonic epilepsy (JME). In the present study, question of whether microstructural variations exist between two subgroups JME, and without photoparoxysmal responses (PPR positive negative), was addressed using diffusion tensor imaging.A selection 18 (eight PPR positive) from a tertiary center diagnosed JME 27 healthy controls studied. The following regions interest were investigated: ascending...
Epilepsy and other seizure disorders account for a high disease burden in Germany. As timely diagnosis accurate treatment are crucial, improving the management of these is important. Outside Germany, outpatient long-term video EEGs (ALVEEGs) have demonstrated potential to support epilepsy disorders. This study aims evaluate implementation ALVEEGs as new diagnostic pathway eastern parts Germany diagnose assess if equally effective current inpatient-monitoring gold standard, which currently...
Gaida, B. J.; Yaldizli, Oezguer O.; Mink, S.; Muroi, C.; Mudra, R.; Fröhlich, J. Author Information
OBJECTIVE To assess whether the cellular function of anti-bacterial defense (chemotaxis, phagocytosis, oxidative burst, degranulation defensins) are altered in monocytes and neutrophil granulocytes derived from stroke patients compared to controls. In neutrophils extracellular trap formation (NETosis) was also studied. BACKGROUND, Pneumonia is a frequent complication ischemic worsens clinical outcome. It has been shown that induces immune alterations (SIIA) which thought be mediated by...
Objective: Stroke-induced immune alterations predispose patients to infections. While the relationship between stroke and adaptive system has been investigated in detail, date it is unknown whether innate system, which forms first line of antibacterial defense, also impaired patients. We therefore chemotaxis, phagocytosis, oxidative burst, degranulation defensins, NETosis monocytes neutrophil granulocytes. Methods: Patients suffering from acute ischemic were recruited within 12 h symptom...
Zusammenfassung Multimorbidität ist die besondere Herausforderung der älter werdenden Gesellschaft. Der ältere Patient mit neu diagnostizierter Epilepsie trägt nicht nur Bürde seiner Epilepsie, sondern zunehmendem Lebensalter dem Risiko komorbider chronischer Erkrankungen ausgesetzt. Die Übersichtsarbeit fokussiert auf kardiovaskuläre bei im höheren und ihren Beitrag zur vorzeitigen Mortalität. Es werden aktuelle Arbeiten zu medikamentösen Interaktionen Komedikation von Antiepileptika (AED)...