A5071995676- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Metabolism and Genetic Disorders
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Infectious Encephalopathies and Encephalitis
- Neuroscience and Neural Engineering
- Genetics and Neurodevelopmental Disorders
- Autoimmune Neurological Disorders and Treatments
- Psychosomatic Disorders and Their Treatments
- Ion channel regulation and function
- Peripheral Neuropathies and Disorders
- Diet and metabolism studies
- Neurological and metabolic disorders
- Neonatal and fetal brain pathology
- Pharmaceutical studies and practices
- Bipolar Disorder and Treatment
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Health Systems, Economic Evaluations, Quality of Life
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2002-2025
Einstein Center for Neurosciences Berlin
2013-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2019-2025
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2025
Essen University Hospital
2025
Evangelisches Krankenhaus Königin Elisabeth Herzberge
2013-2024
Freie Universität Berlin
2018-2024
Pathodiagnostik Berlin
2017-2024
Odense University Hospital
2024
The active electrical properties of dendrites shape neuronal input and output are fundamental to brain function. However, our knowledge has been almost entirely acquired from studies rodents. In this work, we investigated the layer 2 3 (L2/3) pyramidal neurons human cerebral cortex ex vivo. these neurons, discovered a class calcium-mediated dendritic action potentials (dCaAPs) whose waveform effects on have not previously described. contrast typical all-or-none potentials, dCaAPs were...
The objective of the current article was to review literature and discuss degree evidence for various treatment strategies status epilepticus (SE) in adults. We searched MEDLINE EMBASE relevant from 1966 January 2005 updated version all pertinent publications 2009. Furthermore, Cochrane Central Register Controlled Trials (CENTRAL) sought. Recommendations are based on this our judgement relevance references subject. were reached by informative consensus approach. Where there a lack but clear,...
Objective: To assess risk factors and prognosis in patients with refractory status epilepticus (RSE). Methods: We retrospectively analysed all episodes of (SE) treated between 1993 2002 on the neurological intensive care unit (NICU) Charité-Universitätsmedizin Berlin. The predictive prognostic features RSE were compared non-RSE (NRSE). All "de novo" SE followed up to identify possible development post-SE symptomatic epilepsy. Results: A total 83 fulfilled our criteria SE. Of these 43% first...
Following stroke, acute symptomatic seizures (manifestation within seven days) and epilepsy, i.e. occurrence of at least one unprovoked seizure after more than days), are reported in 3-6% up to 12% patients, respectively. Incidence is higher intracranial haemorrhage (10-16%) ischaemic stroke (2-4%). Acute may be associated with unfavourable functional outcome increased mortality. In view the clinical relevance, European Stroke Organisation has issued evidence-based guidelines on management...
To assess the survival rate and functional outcome in elderly patients with space occupying supratentorial infarction who underwent hemicraniectomy compared those received medical treatment alone.All older than 55 years middle cerebral artery (MCA) treated our clinic between January 1998 July 1999 were included this retrospective analysis. Patients eligible for decompressive surgery if they younger 75 had no severe comorbidity. Hemicraniectomy was performed regardless of affected hemisphere....
The objective of the current paper was to review literature and discuss degree evidence for various treatment strategies status epilepticus (SE) in adults. We searched MEDLINE EMBASE relevant from 1966 January 2005. Furthermore, Cochrane Central Register Controlled Trials (CENTRAL) sought. Recommendations are based on this our judgement relevance references subject. were reached by informative consensus approach. Where there a lack but clear we have stated opinion as good practice points....
Background and purpose To clarify the relevance of titres IgG antibodies against contactin‐associated protein‐2 (CASPR2) in diagnosing anti‐CASPR2 encephalitis to describe features outcomes. Methods This was a retrospective analysis 64 patients with CASPR2 antibodies, categorized independently as ‘autoimmune encephalitis’ or ‘other disease’. Logistic regression methods were performed identify potential predictors addition antibodies. Results An upfront antibody serum titre cut‐off at ≥1:200...
Background and aims Stroke is the leading cause of seizures epilepsy in elderly. The aim this study was to assess incidence post-stroke (PSE) based on revised definition International League Against Epilepsy (ILAE) a population-based describe possible predictors. Methods Data from prospective Erlangen Project (ESPro) were collected frequency PSE. Patients followed up 3, 12, 24 months after stroke. diagnosed according WHO PSE new ILAE criteria. Multivariable analysis performed identify...
Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized subsyndrome, contributing to approximately 3% 11% of adolescent and adult cases epilepsy. However, little known about long-term medical evolution this clinical entity. The aim study was analyze outcome in a clinically well-defined series patients with JME for seizure predictors outcome.In retrospective cohort study, we analyzed 66 who had JME, were treated at Department Neurology, Charité-Universitätsmedizin Berlin,...
Abstract Objective Cannabidiol (CBD) is approved for treatment of Dravet syndrome (DS), Lennox‐Gastaut (LGS), and tuberous sclerosis complex (TSC). Several studies suggest antiseizure effects also beyond these three epilepsy syndromes. Methods In a retrospective multicenter study, we analyzed the efficacy tolerability CBD in patients with at 16 centers. Results The study cohort comprised 311 median age 11.3 (0‐72) years (235 children adolescents, 76 adults). Therapy was off‐label 91.3% cases...
The computational capabilities of neuronal networks are fundamentally constrained by their specific connectivity. Previous studies cortical connectivity have mostly been carried out in rodents; whether the principles established therein also apply to evolutionarily expanded human cortex is unclear. We studied network properties within temporal using samples obtained from brain surgery. analyzed multineuron patch-clamp recordings layer 2-3 pyramidal neurons and identified substantial...
Zusammenfassung In der neuen S2k-Leitlinie „Erster epileptischer Anfall und Epilepsien im Erwachsenenalter“ werden Empfehlungen zu klinisch relevanten Fragestellungen in fünf großen Themenblöcken gegeben: Management erster Anfall, Pharmakotherapie, Epilepsiechirurgie, komplementäre supportive Therapieverfahren psychosoziale Aspekte. Beim Thema Leitlinie zunächst zur Unterscheidung beiden maßgeblichen Differenzialdiagnosen, Synkope psychogener nicht-epileptischer gegeben. Zudem wird...
Abstract Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release IL-1β. Extracellular ATP a strong activator inducing K + efflux as key signaling event, suggesting that -permeable ion channels could have high therapeutic potential. In these include ATP-gated THIK-1 P2X7 receptors, but their interactions potential role in human brain are unknown. Using novel specific inhibitor combination with patch-clamp...
Background: Status epilepticus (SE) frequently does not respond to common first-line anticonvulsants.In a substantial portion of patients, administration anticonvulsant anesthetics is inevitable.Even this aggressive approach fails terminate SE in an undefined number cases.We have coined the term malignant for most severe variant SE.Objective: To assess frequency, risk factors, and inhospital outcome SE.Design: Retrospective cohort study.Setting: Neurologic intensive care unit large...
Surgery in frontal lobe epilepsy (FLE) has a worse prognosis regarding seizure freedom than anterior lobectomy temporal epilepsy. The current study aimed to assess whether intracranial interictal and ictal EEG findings addition clinical scalp data help predict outcome series of patients who needed invasive recording for FLE surgery.Patients with had resective surgery after chronic were included. Outcome predictors compared (group 1) those recurrent seizures 2) at 19-24 months...
Despite the obvious advantages of resective surgery in patients with drug-resistant focal epilepsy, namely high probability seizure freedom, decreased mortality, and increased quality life, referral rates from physicians approval by for presurgical assessment remain constantly low.In outpatient clinics a tertiary epilepsy center, checklists were implemented asking treating epileptologists whether they recommended evaluation noninvasive video-electroencephalographic monitoring to adult...
Abstract Objective 18F‐Fluorodeoxyglucose positron emission tomography (FDG‐PET) is widely used in presurgical assessment patients with drug‐resistant focal epilepsy (DRE) if magnetic resonance imaging (MRI) and scalp electroencephalography (EEG) do not localize the seizure onset zone or are discordant. Methods In this multicenter, retrospective observational cohort study, we included consecutive DRE who had undergone FDG‐PET as part of their workup. We assessed utility FDG‐PET, which was...
Abstract Background Acute symptomatic epileptic seizures are frequently seen in neurocritical care. To prevent subsequent unprovoked seizures, long-term treatments with antiseizure medications often initiated although supporting evidence is lacking. This study aimed at prospectively assessing the risk of seizure relapse respect to use medications. It was hypothesized that after a first acute structural etiology, cumulative 12-month ≤ 25%. Methods Inclusion criteria were age ≥ 18 and...