A5061709266- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Neuroscience and Neural Engineering
- Complex Systems and Decision Making
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- CCD and CMOS Imaging Sensors
- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Advanced Fluorescence Microscopy Techniques
- Cellular transport and secretion
- Parasitic infections in humans and animals
- Decision-Making and Behavioral Economics
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Lung Cancer Research Studies
- Nerve injury and regeneration
Charité - Universitätsmedizin Berlin
2017-2024
Humboldt-Universität zu Berlin
2024
Freie Universität Berlin
2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023-2024
Christ University
1911
University of Cambridge
1908-1911
The active electrical properties of dendrites shape neuronal input and output are fundamental to brain function. However, our knowledge has been almost entirely acquired from studies rodents. In this work, we investigated the layer 2 3 (L2/3) pyramidal neurons human cerebral cortex ex vivo. these neurons, discovered a class calcium-mediated dendritic action potentials (dCaAPs) whose waveform effects on have not previously described. contrast typical all-or-none potentials, dCaAPs were...
Abstract The tumorigenesis of small intestinal neuroendocrine tumors (siNETs) is not understood and comprehensive genomic transcriptomic data sets are limited. Therefore, we performed whole genome transcriptome analysis 39 well differentiated siNET samples. Our revealed a lack recurrent driver mutations demonstrated that multifocal siNETs from individual patients can arise genetically independently. We detected germline in Fanconi anemia DNA repair pathway (FANC) genes, involved homologous...
Synaptosomal-associated protein of 47 kDa (SNAP47) isoform is an atypical member the SNAP family, which does not contribute directly to exocytosis and synaptic vesicles (SVs) recycling. Initial characterization SNAP47 revealed a widespread expression in nervous tissue, but little known about its cellular subcellular localization hippocampal neurons. Therefore, present study we applied multiple-immunofluorescence labeling, immuno-electron microscopy situ hybridization (ISH) analyzed pre-...
Abstract Information processing in cortical circuits, including the hippocampus, relies on dynamic control of neuronal activity by GABAergic interneurons (INs). INs form a heterogenous population with defined types displaying distinct morphological, molecular, and physiological characteristics. In major input region dentate gyrus (DG), number IN have been described which provide synaptic inhibition to compartments excitatory principal cells (PrCs) other INs. this study, we perform an...
This study aimed to analyze the impact of interim evaluation on continuation 177Lu-based peptide receptor radionuclide therapy (PRRT) in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and survey its usage across German university hospitals.
Abstract The morphological structure of neurons provides the basis for their functions and is a major focus contemporary neuroscience studies. Intracellular staining single cells in acute slices well-established approach, offering high-resolution information on neuronal morphology, complementing physiology. Despite technical advances, however, common histological artifact often precludes precise analysis: shrinkage sampled tissue after embedding microscopy. Here, we describe new approach...
A subset of neuroendocrine tumors (NETs) can cause an excessive secretion hormones, neuropeptides, and biogenic amines into the bloodstream. These so-called functional NETs evoke a hormone-related disease lead to several different syndromes, depending on factors released. One most common carcinoid syndrome, is characterized mainly by over-secretion serotonin. However, what distinguishes from non-functional molecular level remains unknown. Here, we demonstrate that expression sortilin, widely...
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