A5040721913- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- EEG and Brain-Computer Interfaces
- Genomics and Rare Diseases
- Ion channel regulation and function
- Neural dynamics and brain function
- Genomic variations and chromosomal abnormalities
- Cardiac electrophysiology and arrhythmias
- Hemispheric Asymmetry in Neuroscience
- Memory and Neural Mechanisms
- Advanced battery technologies research
- Olfactory and Sensory Function Studies
- Coenzyme Q10 studies and effects
- Genetic Associations and Epidemiology
- Psychosomatic Disorders and Their Treatments
- Molecular spectroscopy and chirality
- Advanced Neuroimaging Techniques and Applications
- Pregnancy and Medication Impact
- Biochemical Analysis and Sensing Techniques
- Nicotinic Acetylcholine Receptors Study
- Fetal and Pediatric Neurological Disorders
- Vitamin K Research Studies
Philipps University of Marburg
2018-2025
Universitätsklinikum Gießen und Marburg
2018-2024
Hertie Institute for Clinical Brain Research
2022
University of Tübingen
2022
Objectives. To assess first clinical experiences with Brivaracetam (BRV) in the treatment of epilepsies. Methods. Data on patients treated BRV from February to December 2016 and at least one follow-up were collected electronic patient records. safety efficacy evaluated retrospectively. Results. In total, 93 analysed; 12 (12.9%) received monotherapy. Mean duration follow up was 4.85 months (MD=4 months; SD=3.63). Fifty-seven had more than seizure per month baseline a 4 weeks; rate ≥50%...
To develop a predictive model for the classification of seizure freedom under first-line monotherapy with levetiracetam in patients newly diagnosed epilepsy. Clinical data and routine EEG recordings epilepsy who were started on analyzed retrospectively. had been acquired prior to initiation treatment all patients. Patients experienced no further seizures until last follow-up labeled as seizure-free. Spectral features (band power, peak frequency) functional connectivity computed each patient...
<h3>Background and Objectives</h3> <i>KCNC2</i> encodes Kv3.2, a member of the Shaw-related (Kv3) voltage-gated potassium channel subfamily, which is important for sustained high-frequency firing optimized energy efficiency action potentials in brain. The objective this study was to analyze clinical phenotype, genetic background, biophysical function disease-associated Kv3.2 variants. <h3>Methods</h3> Individuals with variants detected by exome sequencing were selected clinical, further...
Abstract Background We investigated the relationship of piriform cortex (PC) structural network centrality with drug resistance and epilepsy duration as markers sustained epileptic activity. Methods PCs were manually delineated on retrospectively collected 3D‐T1‐MRI images patients temporal lobe (TLE). Connectomes computed from diffusion MRI scans, including PC nodes. Betweenness (BC) node degree compared across drug‐resistant versus drug‐sensitive patients. Correlations metrics calculated....
Background In 2014, the ILAE introduced a new definition of epilepsy that allows some patients to be diagnosed earlier than under previously used definition. According old classification, diagnosis was made after second unprovoked seizure. The risk this 36% first aim study is investigate clinical impact on diagnosis, treatment, and short-term outcome. Methods From 2018 2021, adult admitted with epileptic seizure were prospectively included. Demographic data collected at baseline, 6 12 months...
The anatomy of the human piriform cortex (PC) is poorly understood. We used a bimodal connectivity-based-parcellation approach to investigate subregions PC and its connectional differentiation from amygdala. One hundred (55 % female) genetically unrelated subjects Human Connectome Project were included. A region interest (ROI) was delineated bilaterally covering amygdala, functional structural connectivity this ROI with whole gray matter computed. Spectral clustering performed obtain...
Objectives Brivaracetam (BRV) is the latest approved antiepileptic drug and acts as a synaptic vesicle protein 2A ligand. The aim of present study was to evaluate efficacy tolerability BRV in clinical setting. Design Retrospective, observational multicentre study. Setting We retrospectively collected data patients who received 10 epilepsy centres using questionnaire that answered by reporting neurologist. Participants Data 615 treated with were included Primary secondary outcome measures...
Abstract Objective The phenotypic and genotypic spectrum of adult patients with epilepsy intellectual disability (ID) is less clear than in children. We investigated an patient cohort to further elucidate this inform the genetic testing approach. Methods Fifty‐two (30 male, 22 female) epilepsy, at least mild ID no known or acquired cause were included phenotyped. Variants identified through exome sequencing evaluated using ACMG criteria. Identified variants compared commercially available...
Studies on risk factors for epilepsy and seizure recurrence after a first are usually based the old definition of with need two unprovoked seizures. The current allows diagnosis treatment if is >60%. We evaluate decisions, related to application new epilepsy.Data 629 patients were analyzed investigate changes decisions revised epilepsy. used binary logistic regression impact multiple influencing like electroencephalogram (EEG) magnetic resonance imaging (MRI) results administration...
Assessment of regional language lateralization is crucial in many scenarios, but not all populations are suited for its evaluation via task-functional magnetic resonance imaging (fMRI). In this study, the utility structural connectome features classification anterior temporal lobes (ATLs) was investigated. Laterality indices semantic processing ATL were computed from task-fMRI 1038 subjects Human Connectome Project who labeled as stronger rightward lateralized (RL) or leftward to bilaterally...
We report detailed functional MRI (fMRI) analyses in a patient with reflex seizures elicited by driving along specific rural crossroad or watching video thereof. Semiology consisted of epigastric aura, followed sensory seizure the left hand and sporadic automotor seizures. The right amygdala-region (rh-amygdala) was surgically electroclinically confirmed as epileptogenic zone. Presurgical task-fMRI performed, during which videos that (IC), another (NC) noise were presented. Independent...
Objective To investigate correlates in hippocampal subfield volume and verbal visual memory function patients with temporal lobe epilepsy (TLE), mild amnestic cognitive impairment (MCI) heathy participants (HP). Methods 50 right-handed were included this study; 11 18 21 healthy Verbal performance was evaluated via the test (VLMT) diagnosticum for cerebral damage (DCM). Hippocampal volumes of T1-weighted Magnetic Resonance Imaging (MRI) scans computed FreeSurfer version 7.1. Stepwise...
The risk of seizure recurrence after a first unprovoked epileptic is reported to be approximately 40%. Little known about the in elderly patients, who may at higher due an increased rate structural lesions, encephalopathy, subcortical arteriosclerotic encephalopathy or brain atrophy.
This case series describes the clinical features, diagnostic challenges, treatment approaches, and outcomes of three adult patients with COQ8A-related CoQ10 deficiency presenting focal status epilepticus, who were effectively treated at Department Neurology, Philipps University Marburg, Germany. The patients, all from consanguineous families first two being siblings, presented a late onset disease, characterized by progressive cerebellar ataxia epilepsy, deterioration epilepticus occurring...
Abstract Background KCNC2 encodes a member of the shaw-related voltage-gated potassium channel family (K V 3.2), which are important for sustained high-frequency firing and optimized energy efficiency action potentials in brain. Methods Individuals with variants detected by exome sequencing were selected clinical, further genetic functional analysis. The cases referred through clinical research collaborations our study. Four de novo examined electrophysiologically Xenopus laevis oocytes....