A5079563436- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Aortic aneurysm repair treatments
- Brain Metastases and Treatment
- Medical Imaging Techniques and Applications
- Trigeminal Neuralgia and Treatments
- Advanced X-ray and CT Imaging
- Medical Practices and Rehabilitation
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
Klinik Hirslanden
2016-2025
Essen University Hospital
2015-2024
Klinik und Poliklinik für Neurologie
2005-2024
University of Duisburg-Essen
2010-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
Swiss Society of Radiology
2023
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2003-2022
Advanced Imaging Research (United States)
2022
Statistical Research (United States)
2022
KU Leuven
2022
<h3>BACKGROUND AND PURPOSE:</h3> Endoluminal reconstruction with flow diverting devices represents a novel constructive technique for the treatment of cerebral aneurysms. We present results first prospective multicenter trial flow-diverting construct intracranial <h3>MATERIALS METHODS:</h3> Patients unruptured aneurysms that were wide-necked (>4 mm), had unfavorable dome/neck ratios (<1.5), or failed previous therapy enrolled in PITA between January and May 2007 at 4 (3 European 1...
<h3>BACKGROUND AND PURPOSE:</h3> FD technology enables reconstructive repair of otherwise difficult-to-treat intracranial aneurysms. These stentlike devices may induce progressive aneurysm thrombosis without additional implants and initiate complete reverse vessel remodeling. The associated vascular biologic processes are as yet only partially understood. <h3>MATERIALS METHODS:</h3> From 12 different centers, 13 cases delayed postprocedural rupture were recorded analyzed. Symptom, location...
We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making the management of UIAs assess agreement for this among specialists UIA research.
Clazosentan, an endothelin receptor antagonist, has been shown to reduce vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). CONSCIOUS-3 assessed whether clazosentan reduced vasospasm-related morbidity and all-cause mortality postaSAH secured by endovascular coiling.This double-blind, placebo-controlled, phase III trial randomized patients with aSAH coiling ≤ 14 days intravenous (5 or 15 mg/h) placebo. The primary composite end point (all-cause mortality; new cerebral infarcts delayed...
<b>BACKGROUND AND PURPOSE:</b> Endovascular therapy of intracranial arteriovenous malformations (AVMs) is increasingly used. However, it still under discussion which embolic material optimal. We report our experience in the treatment AVMs with ethylene-vinyl alcohol copolymer (Onyx). <b>MATERIALS METHODS:</b> Between July 2002 and January 2008, brain were embolized Onyx 82 consecutive patients department. There 41 females males a mean age 44.2 years (range, 15–85 years). Clinical...
Background and Purpose— The introduction of flow diverters (FDs) has expanded the possibilities for reconstructive treatment difficult intracranial aneurysms. Concern remains as to long-term patency perforating arteries side branches covered during stent placement. Our purpose was evaluate performance early effect on after implantation Silk FD in basilar artery Methods— Twelve patients with an aneurysm that treated by were included our retrospective study. Both unruptured previously...
Higher magnetic field strengths and continuous improvement of high-resolution imaging in multiple sclerosis (MS) are expected to provide unique in-vivo non-invasive insights pathogenesis clinical monitoring. The purpose this study was investigate the potential MS lesions vivo comparing 7T with conventional 1.5T.Twelve consecutive patients clinically definite were scanned on a whole-body scanner 1.5T Avanto. protocol consisted axial proton density (PD) + T2-weighted turbo spin-echo...
To investigate the role of prophylactic cranial irradiation (PCI) within a trimodality protocol (chemotherapy, chemoradiotherapy, surgery) for patients with operable stage IIIA non-small-cell lung cancer (NSCLC).After mediastinoscopic staging, NSCLC were enrolled to German multicenter trial and randomly assigned receive either primary resection followed by adjuvant thoracic radiation therapy (50 60 Gy; arm A) or preoperative chemotherapy (cisplatin/etoposide [PE]; three cycles) concurrent...
Ruptured aneurysms of < 2 mm are not amenable to endovascular coiling and therefore pose a significant treatment challenge.To test recently introduced flow diverters that allow reconstruction via another method may represent new option for such lesions.Three female patients presented with acute subarachnoid hemorrhage. An aneurysm was identified in all as the cause bleeding. The were located at C2 segment internal carotid on basilar bifurcation other. All had failed early attempts. Flow...
Background and Purpose— To address the increasing need to counsel patients about treatment indications for unruptured intracranial aneurysms (UIA), we endeavored develop a consensus on assessment of UIAs among group specialists from diverse fields involved in research UIAs. Methods— After composition group, Delphi was initiated identify rate all features, which may be relevant assess their by using ranking scales analysis inter-rater agreement (IRA) each factor. IRA categorized as very high,...
High blood pressure is one of the main risk factors for cerebral white matter lesions (WMLs). There limited evidence from randomized trial that pressure-lowering able to slow WML progression. We investigated whether telmisartan prevents progression in imaging substudy Prevention Regimen Effectively Avoiding Second Strokes (PRoFESS) trial.This predefined comprised 771 patients (mean age, 65 years) with recent ischemic stroke noncardioembolic origin who received or placebo during a mean...
✓ The authors present two cases of patients with small, acutely ruptured, wide-necked aneurysms the distal vertebral artery that were not amenable to conventional coil embolization and instead treated by means a double-stent method in which one stent was placed inside another. Angiography performed immediately after procedure revealed significant reduction aneurysm filling; total occlusion lesion observed 7 days confirmed 6 months later both aneurysms. By placing other, permeability can be...