A5081502914- Wildlife Ecology and Conservation
- Animal Ecology and Behavior Studies
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bat Biology and Ecology Studies
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Animal Behavior and Reproduction
- Peroxisome Proliferator-Activated Receptors
- Avian ecology and behavior
- Intracranial Aneurysms: Treatment and Complications
- Cholesterol and Lipid Metabolism
- Vascular Malformations Diagnosis and Treatment
- Ecology and Vegetation Dynamics Studies
- Physiological and biochemical adaptations
- Plant and animal studies
- Lipid metabolism and biosynthesis
- Ecology and biodiversity studies
- Liver Disease Diagnosis and Treatment
- Isotope Analysis in Ecology
- Primary Care and Health Outcomes
- Adipose Tissue and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Species Distribution and Climate Change
- Rangeland and Wildlife Management
Durham University
2024
University of Pennsylvania
2014-2023
Institute of Nutrition, Metabolism and Diabetes
2023
Essex Cardiothoracic Centre
2013-2022
Translational Therapeutics (United States)
2006-2022
University of Florida
2021
Hospital of the University of Pennsylvania
2020
University Hospital Southampton NHS Foundation Trust
2017-2018
Western University
2002-2017
Southampton General Hospital
2002-2017
Body condition can have important fitness consequences, but measuring body of live animals from wild populations has been the subject much recent debate. Using residuals a regression mass on linear measure size is one most common methods and used in many vertebrate taxa. Recently, use this method criticized because assumptions are likely violated. We tested several regarding with composition morphometric data five species small mammals statistical simulations. that relationship between...
Patients with homozygous familial hypercholesterolemia have markedly elevated cholesterol levels, which respond poorly to drug therapy, and a very high risk of premature cardiovascular disease. Inhibition the microsomal triglyceride transfer protein may be effective in reducing levels these patients.
A scavenger that protects the heart Coronary disease is a tale of two forms plasma cholesterol. In contrast to well-established effects “bad” cholesterol (LDL-C), role “good” (HDL-C) mysterious. Elevated HDL-C correlates with lower risk disease, yet drugs raise levels do not reduce risk. Zanoni et al. found some people exceptionally high carry rare sequence variant in gene encoding major receptor, receptor BI. This destroys receptor's ability take up HDL-C. Interestingly, this have higher...
<h3>BACKGROUND AND PURPOSE:</h3> FD technology enables reconstructive repair of otherwise difficult-to-treat intracranial aneurysms. These stentlike devices may induce progressive aneurysm thrombosis without additional implants and initiate complete reverse vessel remodeling. The associated vascular biologic processes are as yet only partially understood. <h3>MATERIALS METHODS:</h3> From 12 different centers, 13 cases delayed postprocedural rupture were recorded analyzed. Symptom, location...
Genome-wide association studies (GWAS) have identified a genetic variant at locus on chromosome 1p13 that is associated with reduced risk of myocardial infarction, plasma levels LDL cholesterol (LDL-C), and markedly increased expression the gene sortilin-1 (SORT1) in liver. Sortilin lysosomal sorting protein binds ligands both Golgi apparatus membrane traffics them to lysosome. We previously reported hepatic sortilin mice LDL-C levels. Here we show not only apolipoprotein B (APOB) secretion,...
The idea that the need for energy reserves may have been important in evolution of different body sizes can be traced to Lindsey (1966) who recognized 'the last longer large rather than small animals' and suggested this one possible reason among northern poikilotherms. Several subsequent investigators drew similar conclusions based on studies other taxonomic groups. A number environmental correlates size mammalian carnivores 'homeostatic needs' might set a lower limit at higher latitudes...
After the ingestion of a fat-rich meal, there is postprandial increase in plasma concentration both apolipoprotein B-48- and apoB-100-containing triglyceride-rich lipoproteins (apoB-48 apoB-100 TRL). In order to determine contribution these lipemia, triglycerides (TG) retinyl esters (RE) was measured apoB-48 TRL after an oral fat load. Six normolipidemic male subjects were fed heavy cream (1 g per kg body weight) containing vitamin A (3000 retinol equivalents). isolated by...
Pharmacological inhibition of the cholesteryl ester transfer protein (CETP) in humans increases high-density lipoprotein (HDL) cholesterol (HDL-C) levels; however, its effects on apolipoprotein A-I (apoA-I) containing HDL subspecies, apoA-I turnover, and markers reverse transport are unknown. The present study was designed to address these issues.Nineteen subjects, 9 whom were taking 20 mg atorvastatin for hypercholesterolemia, received placebo 4 weeks, followed by CETP inhibitor torcetrapib...
We quantitatively test theoretical predictions concerning mammalian life histories, using published data on survival, reproduction, and body mass for 29 eutherian mammals. Larger mammals have a greater age at maturity, generation length, expectancy, lower reproductive value smaller litters than do Residual maturity is not correlated with adult or survival. Litter size varies inversely length Age positively expectancy. Twenty—seven of display longer their expectancy birth, the same proportion...
Endothelial lipase (EL) is a recently discovered member of the lipoprotein gene family that hydrolyzes HDL phospholipids ex vivo and reduces cholesterol (HDL-C) levels when overexpressed in mice. To gain further insight into physiological role EL metabolism vivo, studies were performed which was inhibited wild-type, hepatic knockout (HL–/–), human apoA-I transgenic mice by intravenous infusion polyclonal antibody inhibitory to murine EL. As compared with control antibody, resulted 25–60%...
Body condition (energy reserves) can have important fitness consequences. Measuring of live animals is typically done by regressing body mass on measures size and using the residuals as an index condition. The validity this was evaluated determining whether it reflected measured fat content five species small mammals (yellow-pine chipmunks (Tamias amoenus Allen), bushy-tailed wood rats (Neotoma cinerea Ord), deer mice (Peromyscus maniculatus red-backed voles (Clethrionomys gapperi Vigors),...
Six normolipidemic male subjects, after an 8-h overnight fast, were given a bolus injection and then 15-h constant intravenous infusion of [D3]L-leucine. Subjects studied in the fasted state on second occasion fed (small, physiological meals every hour for 15 h). Apolipoproteins isolated by preparative gradient gel electrophoresis from plasma lipoproteins separated sequential ultracentrifugation. Incorporation [D3]L-leucine into apolipoproteins was monitored negative ionization, gas...
International data on quality of medical care allow countries to compare their performance that other countries. The Commonwealth Fund Working Group Quality Indicators collected twenty-one indicators reflect in Australia, Canada, New Zealand, England, and the United States. include five-year cancer relative survival rates, thirty-day case-fatality rates after acute myocardial infarction stroke, breast screening asthma mortality rates. No country scores consistently best or worst overall....
Rationale: Noncoding gene variants at the SORT1 locus are strongly associated with low-density lipoprotein cholesterol (LDL-C) levels, as well coronary artery disease. encodes a protein called sortilin, and hepatic sortilin modulates LDL metabolism by targeting apolipoprotein B–containing lipoproteins to lysosome. Sortilin is also expressed in macrophages, but its role macrophage uptake of atherosclerosis independent plasma LDL-C levels unknown. Objective: To determine effect expression on...
To test the hypothesis that apolipoprotein A-I (apoA-I) functions specifically to inhibit atherosclerosis independent of level high-density lipoprotein cholesterol (HDL-C) by promoting both reverse transport and HDL antiinflammatory function in vivo, we established a murine model apoA-I deficiency which HDL-C is well maintained. ApoA-I −/− mice were crossed with susceptible low-density receptor /apobec (LA) generate LA +/+ , +/− genotypes. There no major differences amounts non–HDL-C plasma...
Captive Peromyscus leucopus exhibited a positive relationship between weight of @V and number size nestlings. Size neonates, but not post—neonatal young was negatively related to litter size. Ingested energy offspring linearly varied from 899 kJ (74% nonbreeding requirements) for 2 2100 (146% 6 offspring. Despite these differences sizes, mean different (° = 4.60 4.94) respectively captive wild females, little seasonally geographically. The relatively constant commitment may be the fact that...
Abstract Nitrogen acquisition is a major challenge for herbivorous animals, and the repeated origins of herbivory across ants have raised expectations that nutritional symbionts shaped their diversification. Direct evidence N provisioning by internally housed rare in animals; among ants, it has been documented just one lineage. In this study we dissect functional contributions bacteria from conserved, multi-partite gut symbiosis Cephalotes through vivo experiments, metagenomics, vitro...
Exercise maintained for approximately eight minutes results in a fall F.E.V.1 rise airway resistance, and impaired gas distribution asthmatic subjects. These effects are usually maximal within 15 after cessation of exercise recovery takes place over the next 30 minutes. Measurement resistance before normal subjects suggests that same mechanism is operating them. Hyperventilation stimulated by inhalation carbon dioxide has failed to produce similar effect. Chlorpromazine, atropine,...
Food intake of females and gross body composition their offspring in relation to stage reproduction development litter size were used evaluate the evolution energy partitioning breeding white-footed mice. Nestlings developed at a constant rate irrespective an adaptive weaning that did not vary with was evident. Females supported primarily through increased food intake. Fat deposited before period peak demand (late lactation) appear important support captive offspring, although fat reserves...
Rationale: An efficient and reproducible source of genotype-specific human macrophages is essential for study macrophage biology related diseases. Objective: To perform integrated functional transcriptome analyses induced pluripotent stem cell–derived (IPSDMs) their isogenic peripheral blood mononuclear (HMDM) counterparts assess the application IPSDM in modeling polarization Mendelian disease. Methods Results: We developed an protocol differentiation IPSDM, which expressed...