A5035888878- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Uterine Myomas and Treatments
- Adrenal and Paraganglionic Tumors
- Urologic and reproductive health conditions
- Pancreatic and Hepatic Oncology Research
- Endometriosis Research and Treatment
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Gynecological conditions and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Intraperitoneal and Appendiceal Malignancies
- Pediatric Hepatobiliary Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Urology and Nephrology Studies
- Pancreatitis Pathology and Treatment
- Genital Health and Disease
University of Pennsylvania
2011-2023
Hospital of the University of Pennsylvania
2013-2022
University of Colorado Colorado Springs
2018-2019
University of North Carolina at Chapel Hill
1996-2015
University of Pennsylvania Health System
1997-2014
Pennsylvania Hospital
2012
University of Bologna
2011
Bordeaux Population Health
2011
Inserm
2011
Centre Hospitalier Universitaire de Bordeaux
2011
Patients with homozygous familial hypercholesterolemia have markedly elevated cholesterol levels, which respond poorly to drug therapy, and a very high risk of premature cardiovascular disease. Inhibition the microsomal triglyceride transfer protein may be effective in reducing levels these patients.
Leiomyomas are the most common uterine neoplasm and composed of smooth muscle with varying amounts fibrous connective tissue. As leiomyomas enlarge, they may outgrow their blood supply, resulting in various types degeneration: hyaline or myxoid degeneration, calcification, cystic red degeneration. classified as submucosal, intramural, subserosal; latter become pedunculated simulate ovarian neoplasms. Although asymptomatic, patients present abnormal bleeding, pressure on adjacent organs,...
Abstract Background Retrospective studies suggest a survival benefit when platinum-based chemotherapy is administered to patients with pancreatic cancer harbouring germline mutation in BRCA1, BRCA2 or PALB2 (mut-positive PDAC). However, the objective response rate (ORR) and real-world progression free (rwPFS) achieved such treatment remain ill-defined. Methods Twenty-six advanced-stage mut-positive PDAC who had been treated therapy were matched by age, race sex 52 platinum-treated control...
PURPOSE: To assess the relationship between quantity of lipid in resected adrenal adenomas and unenhanced computed tomographic (CT) attenuation number relative change signal intensity on chemical shift magnetic resonance (MR) images. MATERIALS AND METHODS: The percentage lipid-rich cortical cells histologic sections from 20 was assessed. results were correlated with corresponding CT or MR images, both. RESULTS: There an inverse linear (R2 = .68, P .0005). a similar to images by using both...
To determine the optimal imaging modality for diagnosis and staging of ovarian cancer.Two hundred eighty women suspected to have cancer were enrolled in a prospective study before surgery. Doppler ultrasonography (US), computed tomography (CT), magnetic resonance (MR) used evaluate mass; conventional US, CT, MR stage spread.All three modalities had high accuracy (0.91) overall malignancy. In ovaries, was higher than that CT significantly US (0.78). extraovarian pelvis abdomen, similar...
To compare magnetic resonance imaging (MRI) and computed tomography (CT) with each other to International Federation of Gynecology Obstetrics (FIGO) clinical staging in the pretreatment evaluation early invasive cervical cancer, using surgicopathologic findings as reference standard.This prospective multicenter study was conducted by American College Radiology Imaging Network Gynecologic Oncology Group from March 2000 November 2002; 25 United States health centers enrolled 208 consecutive...
To assess prospectively the efficacy and safety of postcontrast magnetic resonance (MR) imaging with gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) compared that precontrast MR in patients who are known to have or suspected having liver lesions scheduled for hepatic surgery.Investigational review board approval written informed consent were obtained. HIPAA went into effect after data collection. A total 172 enrolled. After imaging, 169 (94 men, 75 women; mean age,...
Endometriosis, which is defined as the presence of ectopic endometrial glands and stroma outside uterus, a common cause pelvic pain infertility, affecting many 10% premenopausal women. Because its effects may be devastating, radiologists should familiar with various imaging manifestations disease, especially those that allow differentiation from other lesions. The "pearls" offered here are observations culled authors' experience use magnetic resonance (MR) for detection characterization...
PURPOSE: To correlate attenuation values at computed tomography (CT) with signal intensity chemical-shift magnetic resonance (MR) imaging in adrenal masses. MATERIALS AND METHODS: Thirty-eight patients 47 lesions underwent MR and unenhanced CT examinations. examinations, performed 1.5 T, included T1-weighted fat water phase gradient-echo out of (repetition time, 45-180 msec; echo 1.4-3.1 msec). Lesion-to-spleen ratios were calculated for the in-phase opposed-phase images. The ratio, a...
Accuracy of T1-weighted chemical-shift MR imaging for the differentiation between benign and malignant adrenal masses was blindly assessed among three radiologists.MR performed at 1.5 T in 50 patients with 58 masses, proved (n = 38) or 20) based on surgery growth (malignant) stable size (benign) least 1 year. In-phase spin-echo sequences in-phase breath-hold fast multiplanar spoiled gradient-recalled echo (FMPSPGR) a TE 4.2 msec were compared opposed-phase FMPSPGR TR/TE 35-155/2.2-2.9 90...
OBJECTIVE: Aggressive angiomyxoma is a benign tumor affecting the pelvis and perineum, predominantly in women. Because of its variable presentation as soft mass vulva, perianal region, buttock, or pelvis, often clinically misdiagnosed initial surgery usually unsuccessful extirpating it. This study describes imaging features these tumors. CONCLUSION: angiomyxomas display unusual growth patterns translevator extension with around perineal structures. Both CT MR show transdiaphragmatic extent...
PURPOSE: To determine if comparison of in-phase and opposed-phase gradient-echo magnetic resonance (MR) images enables detection lipid in renal clear cell carcinoma. MATERIALS AND METHODS: A retrospective search MR pathologic records identified 43 patients with biopsy-proved masses who underwent imaging. Thirty-three had carcinoma (27 carcinoma), 10 other tumors. With images, a region-of-interest measurement signal intensity the mass was divided by that reference tissue. In each patient,...
To assess the accuracy of using several criteria to evaluate endorectal coil magnetic resonance (MR) images for penetration prostatic capsule.Thirty patients with prostate carcinoma underwent MR imaging and prostatectomy. Specified sites potential capsular on were blindly evaluated by three readers six diagnostic criteria. These evaluations compared pathologic findings analyzed means receiver operating characteristic (ROC) analysis.The area under ROC curve (Az) readers' overall impression...