A5016419487- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Fatty Acid Research and Health
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Cancer, Lipids, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Lipid metabolism and disorders
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Phytoestrogen effects and research
- Nutritional Studies and Diet
- Cardiac Health and Mental Health
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Diabetes and associated disorders
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Risk Factors
- Diabetes Management and Research
- Health Systems, Economic Evaluations, Quality of Life
- Obesity and Health Practices
Beth Israel Deaconess Medical Center
2016-2025
Harvard University
2015-2024
Boston University
2019
Brigham and Women's Hospital
1995-2016
Yale University
2016
University of Pennsylvania
2005-2015
University of Ottawa
2015
Columbia University
2015
Houston Institute for Clinical Research
2015
Dupont Hospital
2015
Hypertriglyceridemia (triglycerides 200-499 mg/dL) is relatively common in the United States, whereas more severe triglyceride elevations (very high triglycerides, ≥500 are far less frequently observed. Both becoming increasingly prevalent States and elsewhere, likely driven large part by growing rates of obesity diabetes mellitus. In a 2002 American Heart Association scientific statement, omega-3 fatty acids (n-3 FAs) eicosapentaenoic acid (EPA) docosahexaenoic (DHA) were recommended (at...
Abstract Chronic low-degree inflammation is a hallmark of atherosclerotic cardiovascular (CV) disease. To assess the effect lipid-lowering therapies on C-reactive protein (CRP), biomarker inflammation, we conducted meta-analysis according to PRISMA guidelines. Databases were searched from inception July 2023. Inclusion criteria were: (i) randomized controlled trials (RCTs) in human, Phase II, III, or IV; (ii) English language; (iii) comparing drugs vs. placebo; (iv) reporting effects CRP...
Although extensive evidence indicates that estrogen is responsible for the markedly decreased cardiovascular risk of premenopausal women, mechanism through which might exert its protective effect has not been adequately explained. Since thrombosis now recognized to play an important role in onset disease, we investigated relation between status and fibrinolytic potential, a determinant thrombotic risk.We determined levels plasminogen activator inhibitor (PAI-1) antigen tissue (TPA) 1431...
Background— Women have been underrepresented in statin trials, and few data exist on the effectiveness safety of statins this gender. We used sequential electron-beam tomography (EBT) scanning to quantify changes coronary artery calcium (CAC) as a measure atherosclerosis burden patients treated with statins. Methods Results— In double-blind, multicenter trial, we randomized 615 hyperlipidemic, postmenopausal women intensive (atorvastatin 80 mg/d) moderate (pravastatin 40 lipid-lowering...
Pharmacological inhibition of the cholesteryl ester transfer protein (CETP) in humans increases high-density lipoprotein (HDL) cholesterol (HDL-C) levels; however, its effects on apolipoprotein A-I (apoA-I) containing HDL subspecies, apoA-I turnover, and markers reverse transport are unknown. The present study was designed to address these issues.Nineteen subjects, 9 whom were taking 20 mg atorvastatin for hypercholesterolemia, received placebo 4 weeks, followed by CETP inhibitor torcetrapib...
A simple and robust LC-MS-based methodology for the investigation of lipid mixtures is described, its application to analysis human lipoprotein-associated lipids demonstrated. After an optional initial fractionation on Silica 60, normal-phase HPLC-MS a YMC PVA-Sil column used first class separation, followed by reversed-phase LC-MS or LC-tandem mass spectrometry using Atlantis dC18 capillary column, and/or nanospray MS, fully characterize individual lipids. The applied here apolipoprotein...
<h3>Background</h3> Epidemiologic studies suggest a low incidence of cardiovascular disease in populations that consume dietary soy. For people aged 40 to 70 years, each increment 20 mm Hg systolic blood pressure (BP) or 10 diastolic BP doubles the risk for BPs 115/75 185/115 Hg. <h3>Methods</h3> To determine effect soy nuts on and lipid levels, 60 healthy postmenopausal women were randomized crossover design Therapeutic Lifestyle Changes (TLC) diet alone TLC similar energy, fat, protein...
Inflammation in arterial walls leads to coronary artery disease (CAD). Because specialized proresolving lipid mediators (SPMs; lipoxins, resolvins, and protectins) stimulate resolution of inflammation animal models, we tested whether n-3 fatty acids impact SPM profiles patients with CAD promote clot remodeling. Six stable were randomly assigned either treatment daily 3.36 g Lovaza for 1 yr or without. Targeted mediator-metabololipidomics showed that both groups had absence resolvin D1...
Objective The study of obesity-related metabolic syndrome or Type 2 diabetes (T2D) in children is particularly difficult because fear needles. We tested a non-invasive approach to inflammatory parameters an at-risk population provide proof-of-principle for future investigations vulnerable subjects. Design and Methods evaluated differences 744, 11-year old selected from underweight, normal healthy weight, overweight obese categories by analyzing fasting saliva samples 20 biomarkers. Saliva...
Increased life expectancy is associated with an increase in the burden of chronic cardiovascular disease.To assess efficacy and safety high-dose atorvastatin patients 65 years age or older.A prespecified secondary analysis Treating to New Targets study, a randomized, double-blind clinical trial.256 sites 14 countries participating study.10,001 (3809 > =65 age) coronary heart disease (CHD) low-density lipoprotein cholesterol levels less than 3.4 mmol/L (<130 mg/dL).Patients were randomly...
To determine mechanisms contributing to decreased high-density lipoprotein cholesterol (HDL-C) and increased low-density (LDL-C) concentrations associated with hydrogenated fat intake, kinetic studies of apoA-I, apoB-100, apoB-48 were conducted using stable isotopes.Eight postmenopausal hypercholesterolemic women provided in random order 3 diets for 5-week periods. Two-thirds the was soybean oil (unsaturated fat), stick margarine (hydrogenated or butter (saturated fat). Total LDL-C levels...
Background Although statins reduce cardiovascular events, residual risk remains. Therefore, additional modalities are needed to risk. We evaluated the effect of eicosapentaenoic acid and docosahexaenoic in pharmacologic doses added statin treatment on coronary artery plaque volume. Methods Results A total 285 subjects with stable disease were randomized omega‐3 ethyl‐ester (1.86 g 1.5 daily) or no (control) for 30 months. Coronary volume was assessed by computed tomographic angiography. Mean...
Studies of sex-based differences in older adults with acute myocardial infarction (AMI) have yielded mixed results. We, therefore, sought to evaluate presentation characteristics, treatments, functional impairments, and in-hospital complications a large, well-characterized population (≥75 years) hospitalized AMI.We analyzed data from participants enrolled SILVER-AMI (Comprehensive Evaluation Risk Factors Older Patients With Acute Myocardial Infarction)-a prospective observational study...