A5015038856- Rabies epidemiology and control
- Virology and Viral Diseases
- Microbial infections and disease research
- Poxvirus research and outbreaks
- Viral Infections and Vectors
- Yersinia bacterium, plague, ectoparasites research
- Viral Infections and Outbreaks Research
- Streptococcal Infections and Treatments
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Human-Animal Interaction Studies
- Bacillus and Francisella bacterial research
- Zoonotic diseases and public health
- Vector-Borne Animal Diseases
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Animal Virus Infections Studies
- Bat Biology and Ecology Studies
- Venomous Animal Envenomation and Studies
- Virus-based gene therapy research
- Wildlife Ecology and Conservation
- Bacteriophages and microbial interactions
- Dialysis and Renal Disease Management
- Influenza Virus Research Studies
- Toxoplasma gondii Research Studies
Alfried Krupp Hospital
2025
Center for Pediatric Endocrinology Zurich
2025
University Hospital of Zurich
1988-2024
University of Göttingen
2024
University of Bern
2021-2024
Sana Klinikum
2023-2024
Friedrich-Loeffler-Institut
2014-2023
Springer Nature (Germany)
2020-2023
University Hospital of Bern
2021-2022
University of Freiburg
2022
Background Rabies is a notoriously underreported and neglected disease of low-income countries. This study aims to estimate the public health economic burden rabies circulating in domestic dog populations, globally on country-by-country basis, allowing an objective assessment how much this preventable costs endemic Methodology/Principal Findings We established relationships between mortality prevention control measures, which we incorporated into model framework. used data derived from...
Despite perceived challenges to controlling an infectious disease in wildlife, oral rabies vaccination (ORV) of foxes has proved a remarkably successful tool and prime example sophisticated strategy eliminate from wildlife reservoirs. During the past three decades, implementation ORV programmes 24 countries led elimination fox-mediated vast areas Western Central Europe. In this study, we evaluated efficiency 22 European between 1978 2010. period area almost 1.9 million km² was targeted...
Abstract Background The burden and timeline of posttransplant infections are not comprehensively documented in the current era immunosuppression prophylaxis. Methods In this prospective study nested within Swiss Transplant Cohort Study (STCS), all clinically relevant were identified by transplant–infectious diseases physicians persons receiving solid organ transplant (SOT) between May 2008 December 2014 with ≥12 months follow-up. Results Among 3541 SOT recipients, 2761 (1612 kidney, 577...
Raccoon dogs might have been intermediate hosts for severe acute respiratory syndrome-associated coronavirus in 2002-2004. We demonstrated susceptibility of raccoon to syndrome 2 infection and transmission in-contact animals. Infected animals had no signs illness. Virus replication tissue lesions occurred the nasal conchae.
The diagnosis of rabies is routinely based on clinical and epidemiological information, especially when exposures are reported in rabies-endemic countries. Diagnostic tests using conventional assays that appear to be negative, even undertaken late the disease despite diagnosis, have a tendency, at times, unreliable. These rarely optimal entirely dependent nature quality sample supplied. In course past three decades, application molecular biology has aided development result more rapid...
This article describes multiple transmissions of rabies via transplanted solid organ from a single infected donor. The empirical Milwaukee treatment regimen was used in the recipients.Symptomatic patients were treated by deep sedation (ketamine, midazolam, and phenobarbital), ribavirin, interferon, active passive vaccination. Viral loads antibodies continuously monitored.Recipients both cornea liver transplants developed no symptoms. recipient transplant had been vaccinated approximately 20...
In Europe, the elimination of wildlife rabies using oral vaccination [ORV] foxes for more than 30 years has been a success story. Since comprehensive review on scope different vaccine baits distributed across Europe not available yet, we evaluated use over entire period ORV [1978–2014]. Our findings provide valuable insights into complexity programs in terms related issues. More 10 vaccines against were used past four decades. Depending many factors, extent to which virus varied considerably...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of infected humans and hundreds thousands fatalities. As the novel disease - referred to as COVID-19 unfolded, occasional anthropozoonotic infections animals by owners or caretakers were reported in dogs, felid species farmed mink. Further shown be susceptible under experimental conditions. The extent natural animals, however, is still largely unknown. Serological methods will useful tools for...
Domestic dogs are responsible for nearly all the »59,000 global human rabies deaths that occur annually. Numerous control measures have been successful at eliminating dog-mediated in upper-income countries, including dog population management, parenteral vaccination programs, access to vaccines, and education programs bite prevention wound treatment. Implementing these techniques resource-poor settings can be challenging; perhaps greatest challenge is maintaining adequate herd immunity...
Licensed rabies virus vaccines based on whole inactivated are effective in humans. However, there is a lack of detailed investigations the elicited immune response, and whether responses can be improved using novel vaccine platforms. Here we show that two doses lipid nanoparticle-formulated unmodified mRNA encoding glycoprotein (RABV-G) induces higher levels RABV-G specific plasmablasts T cells blood, plasma bone marrow compared to Rabipur non-human primates. The also generates binding...
As the demand for rabies post-exposure prophylaxis (PEP) treatments has increased exponentially in recent years, limited supply of human and equine immunoglobulin (HRIG ERIG) failed to provide required passive immune component PEP countries where canine is endemic. Replacement HRIG ERIG with a potentially cheaper efficacious alternative biological treatment humans, therefore, remains high priority. In this study, we set out assess mouse monoclonal antibody (MoMAb) cocktail ultimate goal...
Background Bats receive increasing attention in infectious disease studies, because of their well recognized status as reservoir species for various agents. This is even more important, bats with capability long distance dispersal and complex social structures are unique the way microbes could be spread by these mammalian species. Nevertheless, infection studies predominantly limited to identification specific pathogens presenting a potential health threat humans. But impact agents on...
We report the first full-length genomic sequences for European bat lyssavirus type-1 (EBLV-1) and type-2 (EBLV-2). The EBLV-1 sequence was derived from a virus isolated serotine in Hamburg, Germany, 1968 EBLV-2 isolate human case of rabies that occurred Scotland 2002. A long-distance PCR strategy used to amplify open reading frames (ORFs), followed by standard modified RACE (rapid amplification cDNA ends) techniques 3' 5' ends. lengths each complete viral genome were 11 966 930 base pairs,...
Rabies, a vaccine preventable neglected tropical disease, still claims an estimated 35,000-60,000 human lives annually. The international community, with more than 100 endemic countries, has set global target of 0 deaths from dog-transmitted rabies by 2030. While it been proven in several countries and regions that elimination as public health problem is feasible tools are available, globally have not yet prevented effectively. there extensive research, specific areas implementation for...
Rabies is a neglected zoonotic disease that causes an estimated 60,000 human deaths annually. The main burden lies on developing countries in Asia and Africa, where surveillance detection hampered by absence of adequate laboratory facilities and/or the difficulties submitting samples from remote areas to laboratories. Under these conditions, easy-to-use tests such as immunochromatographic assays, i.e. lateral flow devices (LFD), may increase improve control efforts. Several LFDs for rabies...