A5065899829- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Optical Coherence Tomography Applications
- German Literature and Culture Studies
- Cutaneous lymphoproliferative disorders research
- Sociology and Education Studies
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Public Administration and Political Analysis
- CAR-T cell therapy research
- Skin Protection and Aging
- European history and politics
- Acne and Rosacea Treatments and Effects
- Genetic and rare skin diseases.
- Cancer and Skin Lesions
- Medical Device Sterilization and Disinfection
- Rabies epidemiology and control
- Cell Adhesion Molecules Research
- Infant Nutrition and Health
- Diet and metabolism studies
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Nail Diseases and Treatments
Ludwig-Maximilians-Universität München
2007-2025
LMU Klinikum
2014-2025
Roche Pharma AG (Germany)
2024
Sartorius (Germany)
2019-2024
Helmholtz Zentrum München
2014-2021
Hexal (Germany)
2021
Freie Universität Berlin
2021
Institut für Medien- und Kommunikationspolitik
2021
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2020
Philipps University of Marburg
2005-2018
Ca2+-influx through transient receptor potential (TRP) channels was proposed to be important in endothelial function, although the precise role of specific TRP is unknown. Here, we investigated putatively mechanosensitive TRPV4 channel mechanisms endothelium-dependent vasodilatation.Expression and function rat carotid artery cells (RCAECs) by using situ patch-clamp techniques, single-cell RT-PCR, Ca2+ measurements, pressure myography (CA) Arteria gracilis. In RCAECs situ, currents were...
ABSTRACT Diet can influence the composition of human microbiome, and yet relatively few dietary ingredients have been systematically investigated with respect to their impact on functional potential microbiome. Dietary resistant starch (RS) has shown health benefits, but we lack a mechanistic understanding metabolic processes that occur in gut during digestion RS. Here, collected samples crossover study diets containing large or small amounts We determined RS microbiome pathways gut, using...
The endothelium plays a key role in the control of vascular tone and alteration endothelial cell function contributes to several cardiovascular disease states. Endothelium-dependent dilation is mediated by NO, prostacyclin, an endothelium-derived hyperpolarizing factor (EDHF). EDHF signaling thought be initiated activation Ca(2+)-activated K(+) channels (K(Ca)), leading hyperpolarization subsequently relaxation smooth muscle. In present study, we tested functional intermediate-conductance...
This article describes multiple transmissions of rabies via transplanted solid organ from a single infected donor. The empirical Milwaukee treatment regimen was used in the recipients.Symptomatic patients were treated by deep sedation (ketamine, midazolam, and phenobarbital), ribavirin, interferon, active passive vaccination. Viral loads antibodies continuously monitored.Recipients both cornea liver transplants developed no symptoms. recipient transplant had been vaccinated approximately 20...
Plasmid DNA encoding human interleukin 12 (IL-12) was produced under GMP conditions and injected into lesions of nine patients with malignant melanoma (stage IV) previously treated both standard nonstandard therapies. The treatment based on efficacy in preclinical studies mice gray horses. applied cycles, three injections per cycle, for up to seven cycles. Three therapy arms comprised low (2 mg), medium (4 high (10 20 mg) amounts total DNA. well tolerated. experienced a clinical response:...
<h3>Background</h3> Imiquimod is a local immune response modifier that has demonstrated potent antiviral and antitumor activity. It enhances innate acquired responses via endogenous cytokine production proven efficacious in clearing superficial basal cell carcinoma (sBCC). <h3>Objective</h3> To evaluate the mechanisms by which topical imiquimod treatment leads to sBCC clearance vivo. <h3>Design</h3> A pilot, open-label, nonrandomized study. <h3>Setting</h3> Zurich, Switzerland....
Summary Background In many Demodex-associated skin diseases Demodex mites are present in abundance and seem to be at least partially pathogenic. So far all diagnostic approaches such as scraping or standardized superficial biopsy (semi-)invasive may cause discomfort the patient. Objectives To see whether confocal laser scanning microscopy (CLSM) – a noninvasive method for visualization of layers is able detect quantify D. folliculorum facial patients with rosacea. Methods Twenty-five (34–72...
Optical coherence tomography (OCT) allows real-time, in vivo examination of basal cell carcinoma (BCC). A new high definition OCT with lateral and axial resolution a horizontal (en-face) vertical (slice) imaging mode offers additional information the diagnosis BCC may potentially replace invasive diagnostic biopsies.To define characteristic morphologic features by using optical (HD-OCT) compared to conventional histology.A total 22 BCCs were examined preoperatively HD-OCT en-face slice...
Abstract Background High‐definition optical coherence tomography scanners have recently been developed. Objectives To assess the diagnostic performance of HD ‐ OCT in differentiation benign melanocytic skin lesions ( MSL ) and cutaneous melanoma CM ). Methods Patients with were assessed by . All diagnoses histopathologically confirmed. One blinded observer evaluated both slice en‐face images diagnosed MLS on basis an algorithm adopted from reflectance confocal microscopy, recent reports,...
Background In advanced adrenocortical carcinoma (ACC), the response rate to immune checkpoint inhibition (ICI) is only ~15%. Glucocorticoid (GC) secretion and activation of Wnt/β-catenin pathway have been suggested contribute low tumour cell infiltration. The transcription factor lymphoid enhancer 1 (LEF-1) transduces β-catenin ( CTNNB1 )-mediated transcriptional activation. Objective To understand contribution glucocorticoid receptor (GR) signalling immunologically cold ACC...
A pegylated interferon, peginterferon alfa-2a (PEG-IFNalpha-2a; 40 kd), has the potential for improved tumor response and survival with lower toxicity than IFNalpha. This open-label, randomized study evaluated safety, tolerability, efficacy of subcutaneous PEG-IFNalpha-2a in patients metastatic malignant melanoma (stage IV American Joint Committee on Cancer staging system).PEG-IFNalpha-2a was administered subcutaneously at 180 (n = 48), 360 53), or 450 mug 49) once weekly 24 weeks,...
Nestin is an intermediate filament expressed in proliferating neural progenitor cells and has been considered as a stem cell marker. also found melanoma we recently demonstrated that its expression lines regulated by the transcription factors SOX9 SOX10, but not BRN2. In this study, levels of nestin, BRN2, SOX10 were analysed tissues (n = 78) melanocytic nevi 26) immunohistochemistry. All proteins highly primary metastatic melanomas and, apart from showed much lower nevi. Significant...
Optical coherence tomography (OCT) allows real-time, in vivo examination of nonmelanoma skin cancer. An innovative high-definition (HD)-OCT with a horizontal (en-face) and vertical (slice) imaging mode offers additional information the diagnosis actinic keratosis (AK) may potentially replace invasive diagnostic biopsies. To define characteristic morphological features AK by using HD-OCT two modes compared histopathology as gold standard. In total, 20 AKs were examined en-face slice described...
High-definition optical coherence tomography (HD-OCT) scanners have recently been developed. We assessed micromorphological HD-OCT correlates of benign naevi (BN) and malignant melanoma (MM). 28 BN 20 MM were studied using histology. Epidermal honeycomb/cobblestone pattern, regular junctional cell nests, edged papillae are more often observed in BN, whereas fusion rete ridges, pagetoid cells and/or dermal nests with atypical frequently seen MM. A high overlap features was 20% we did not find...
The early-life metabolome of the intestinal tract is dynamically influenced by colonization gut microbiota which in turn affected nutrition, i.e. breast milk or formula. A detailed examination fecal metabolites was performed to investigate effect probiotics formula compared control and within first months life healthy neonates. broad metabolomics approach conceptualized describe polar semi-polar feeding type year life. Fecal metabolomes were clearly distinct between formula- breastfed...