A5080914578- Estrogen and related hormone effects
- DNA and Nucleic Acid Chemistry
- Cancer, Hypoxia, and Metabolism
- Erythrocyte Function and Pathophysiology
- Adrenal and Paraganglionic Tumors
- Glioma Diagnosis and Treatment
- Free Radicals and Antioxidants
- NF-κB Signaling Pathways
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic function and diabetes
- Pituitary Gland Disorders and Treatments
- Immunotherapy and Immune Responses
- Chemical Reactions and Isotopes
- Biochemical and Molecular Research
- Analytical Chemistry and Chromatography
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Hormonal and reproductive studies
- HIV/AIDS drug development and treatment
- Hypothalamic control of reproductive hormones
- Amino Acid Enzymes and Metabolism
- HIV Research and Treatment
Universitätsklinikum Würzburg
2024-2025
Philipps University of Marburg
1988-1990
Johannes Gutenberg University Mainz
1987
Steroid hormone receptors induce genes by virtue of their interaction with DNA regulatory sequences. The hormonal response a particular gene in vivo correlates binding the to receptor and supposedly reflects degree occupancy corresponding However, vitro steroid-free glucocorticoid progesterone bind specifically sequences mouse mammary tumor virus, thus raising questions on role vivo. By using monoclonal antibodies, gel retardation assays, filter techniques we show here that functional...
Adrenocortical carcinoma (ACC) is a rare yet devastating tumour of the adrenal gland with molecular pathology that remains incompletely understood. To gain novel insights into cellular landscape ACC, we generated single-nuclei RNA sequencing (snRNA-seq) data sets from twelve ACC samples and analysed these alongside snRNA-seq normal glands (NAGs). We find microenvironment to be relatively devoid immune cells compared NAG tissues, consistent known high purity values for as an immunologically...
Endocrine, but also many non-endocrine cancers produce hormones that modulate immune-recognition and -therapy. Here, we used adrenocortical carcinoma (ACC) as model produces high amounts of glucocorticoids (GCs) studied cancer antigen expression recognition. Our study revealed the oncofetal ROR1 is induced by autocrine GC-signaling its transcription regulated GC-activated human glucocorticoid receptor (hGR) in complex with STAT3. To exploit exalted on ACC, engineered ROR1-specific chimeric...
Background In advanced adrenocortical carcinoma (ACC), the response rate to immune checkpoint inhibition (ICI) is only ~15%. Glucocorticoid (GC) secretion and activation of Wnt/β-catenin pathway have been suggested contribute low tumour cell infiltration. The transcription factor lymphoid enhancer 1 (LEF-1) transduces β-catenin ( CTNNB1 )-mediated transcriptional activation. Objective To understand contribution glucocorticoid receptor (GR) signalling immunologically cold ACC...
The integration protein of the human immunodeficiency virus type 1 was purified from recombinant bacteria overproducing this enzyme. final step purification, namely chromatography on polyUsepharose, yielded a homogeneous preparation showing specific DNA cutting and joining activities. For convenient assay endonuclease reaction, 21-mer duplex oligonucleotide corresponding to U5-LTR end viral radiolabeled at dinucleotide that is removed by After mixtures were passed through DEAE-cellulose...
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Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)