A5070733934- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
LMU Klinikum
2025
Ludwig-Maximilians-Universität München
2024-2025
Background In advanced adrenocortical carcinoma (ACC), the response rate to immune checkpoint inhibition (ICI) is only ~15%. Glucocorticoid (GC) secretion and activation of Wnt/β-catenin pathway have been suggested contribute low tumour cell infiltration. The transcription factor lymphoid enhancer 1 (LEF-1) transduces β-catenin ( CTNNB1 )-mediated transcriptional activation. Objective To understand contribution glucocorticoid receptor (GR) signalling immunologically cold ACC...
Endogenous hypercortisolism presents with variable phenotypes. Etiological factors accounting for the level of or varying severity associated comorbidities are lacking. Recently, adrenal ATP-binding cassette B1 (ABCB1) gene was identified as a modulator glucocorticoid secretion.