A5019313636- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Adrenal and Paraganglionic Tumors
- Clinical Reasoning and Diagnostic Skills
- Hormonal Regulation and Hypertension
- Growth Hormone and Insulin-like Growth Factors
- Innovations in Medical Education
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Radiology practices and education
- Machine Learning in Healthcare
- Meta-analysis and systematic reviews
- Scientific Computing and Data Management
- Graph Theory and Algorithms
- Problem and Project Based Learning
- Hormonal and reproductive studies
- Cancer, Hypoxia, and Metabolism
- Education Methods and Technologies
- Interprofessional Education and Collaboration
- Blood Pressure and Hypertension Studies
- Empathy and Medical Education
- Stress Responses and Cortisol
- Ophthalmology and Eye Disorders
- Neural Networks and Applications
- Statistics Education and Methodologies
Ludwig-Maximilians-Universität München
2017-2025
LMU Klinikum
2017-2025
University of Zurich
2023
Justus-Liebig-Universität Gießen
2023
München Klinik
2017-2021
Akdeniz University
2012
Helios Klinikum Erfurt
2009
University Hospital Leipzig
2001
Abstract Context Cushing syndrome (CS) is a rare and serious disease with high mortality. Patients are often diagnosed late in the course of disease. Objective This work investigated whether defined patient populations should be screened outside at-risk current guidelines. Methods As part prospective German registry, we studied 377 patients suspected CS. The chief complaint for CS referral was documented. Using urinary free cortisol, late-night salivary 1-mg dexamethasone suppression test as...
Abstract Context Glucocorticoid-induced myopathy is a characteristic symptom of endogenous Cushing’s syndrome (CS). Its long-term outcome largely unknown. Objective To evaluate muscle function following the remission CS. Study Design Observational longitudinal cohort study. Setting Tertiary care hospitals and specialized outpatient clinic. Patients As part prospective multicenter German Registry, we assessed strength in patients with overt We studied at time diagnosis (n = 88), after 6...
Abstract Importance Endogenous Cushing's syndrome (CS) leads to profound immunosuppression. Successful surgery induces biochemical remission and reversal of immunosuppression, which is characterized by clinical signs glucocorticoid withdrawal associated with increased susceptibility infections thromboembolic complications. Objective We hypothesized that the phase low-grade inflammation may be related patient-relevant outcomes. Setting In this retrospective observational study, we analyzed...
Context Diagnostic efficiency is important in daily clinical practice as doctors have to face problems within a limited time frame. To foster the reasoning of students major challenge medical education research. Little known about students' diagnostic efficiency. On basis current theories, scaffolds for case representation (statement far it summarised mind) could be promising approach make intermediate more efficient. Methods Clinical processing 88 their fourth and fifth years was analysed...
Symptoms of hyperandrogenism are common in patients with Cushing's disease (CD), yet they not sufficiently explained by androgen concentrations. In this study, we analyzed the contribution 11-oxygenated C19 steroids (11oxC19) to hyperandrogenemia female CD.We assessed saliva day profiles females CD pre (n = 23) and post 13) successful transsphenoidal surgery, 26 controls, 5 treated metyrapone osilodrostat for cortisol, cortisone, androstenedione (A4), 11-hydroxyandrostenedione (11OHA4),...
Diagnostic errors occur frequently in daily clinical practice and put patients' safety at risk. There is an urgent need to improve education on reasoning reduce diagnostic errors. However, little known about of medical students. In this study, the nature causes made by students was analyzed.In June 2016, 88 worked eight cases with chief complaint dyspnea a laboratory setting using electronic learning platform, summary 704 processed cases. The steps were tracked analyzed. Furthermore, after...
ABSTRACT Endogenous Cushing's syndrome (CS) is a rare cause of secondary osteoporosis. The long-term consequences for bone metabolism after successful surgical treatment remain largely unknown. We assessed mineral density and fracture rates in 89 patients with confirmed at the time diagnosis 2 years tumor resection. determined five turnover markers diagnosis, 1 postoperatively. osteocalcin, intact procollagen-IN-propeptide (PINP), alkaline phosphatase, CTX-I, TrAcP 5b were measured plasma or...
The aim of this study was to evaluate the accuracy and safety transcutaneous bilirubinometry in preterm infants using new bilirubin analyser Bili Check ± . included 145 children (23–36 wk gestation). Capillary blood sampling for determination serum (BS) combined with measurement (BTc) every morning until sixth postnatal day related several clinical data (phototherapy (PT), infection signs, breathing disturbances, skin bleeding, etc.). Overall concentration ranged from 17 371 μmol/l, 21 325...
Abstract Background Understanding clinical reasoning is a major challenge in medical education research. Little known about the influence of scaffolding and feedback on students. The aim this study was to measure effects problem representation (cognitive case) structured for reflection with or without diagnostic efficiency characterization errors Methods One hundred forty-eight advanced students were randomly assigned one five groups (2 × 2 design control group). They worked 15 virtual cases...
Cushing's syndrome (CS) is a rare disease of endogenous hypercortisolism associated with high morbidity and mortality. Diagnosis classification CS still challenging.Circulating microRNAs (miRNAs) are minimally invasive diagnostic markers. Our aim was to characterize the circulating miRNA profiles patients identify distinct between two major subtypes.We included three groups from German registry: ACTH-independent (Cortisol-Producing-Adenoma; CPA), ACTH-dependent pituitary (Cushing's Disease;...
Glucocorticoid excess leads to muscle atrophy and weakness in patients with endogenous Cushing's syndrome. Insulin-like growth factor I (IGF-I) is known have protective effects on loss. We hypothesized that individual serum IGF-I concentrations might be predictive for long-term myopathy outcome syndrome.In a prospective longitudinal study of 31 florid syndrome, we analyzed IGF binding protein 3 (IGFBP 3) at the time diagnosis following surgical remission over period up years. assessed...
Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing's syndrome. Current guidelines recommend adrenalectomy for PBMAH, but several studies showed clinical effectiveness unilateral despite disease in selected patients. Our aim was to evaluate the gain information which can be obtained through adrenal venous sampling (AVS) based cortisol lateralization ratios guidance adrenalectomy.We performed retrospective analysis 16 patients with...
Abstract When physicians are asked to determine the positive predictive value from a priori probability of disease and sensitivity false rate medical test (Bayesian reasoning), it often comes misjudgments with serious consequences. In daily clinical practice, however, is not only important that doctors receive tool which they can correctly judge—the speed these judgments also crucial factor. this study, we analyzed accuracy efficiency in Bayesian inferences. an empirical study varied...
The main aim of medical curricula is to prepare students for the first day at work place. While teaching clinical competence pivotal, clerkships are often last chance close knowledge gaps with help teachers. Self-directed learning a dynamic field research within education, though its curricular implementation rare. This study focuses on needs assessment using concept self-directed learning.
Abstract Objective Endogenous Cushing's syndrome (CS) is a severe condition, often diagnosed at late stage. To reduce mortality, early diagnosis plays an important role. Two screening tools for identification of patients with CS have been developed in multicentric cohorts, but not yet validated cohorts different geographic backgrounds. Design We the Spanish score published by Leon-Justel et al. 2016 and Italian Parasiliti-Caprino 2021 our cohort. Methods In German Cushing registry, confirmed...
Abstract Context An important clinical feature of Cushing’s syndrome (CS) is proximal muscle myopathy caused by glucocorticoid induced protein metabolism. However, interindividual differences cannot be explained solely the pure extent hypercortisolemia. Objective To evaluate effects receptor (GR) polymorphisms (BclI, N363S, ER22/23EK and A3669G), which influence peripheral sensitivity on muscular function in endogenous CS. Methods 205 patients with proven CS (128 central, 77 adrenal) from 3...
Primary aldosteronism (PA) is the most frequent form of endocrine hypertension. Besides its deleterious impact on cardiovascular target organ damage, PA considered to cause osteoporosis.We assessed bone turnover in a subset 36 postmenopausal women with PA. 18 patients had unilateral and were treated by adrenalectomy, whereas bilateral received mineralocorticoid receptor antagonist (MRA) therapy respectively. age- BMI-matched females served as controls. To estimate remodeling, we measured...