A5042868880- Cardiac Valve Diseases and Treatments
- Hormonal Regulation and Hypertension
- Infective Endocarditis Diagnosis and Management
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Pituitary Gland Disorders and Treatments
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Blood Pressure and Hypertension Studies
- Circadian rhythm and melatonin
- Mechanical Circulatory Support Devices
- Cancer-related gene regulation
- Cardiovascular Function and Risk Factors
- Supramolecular Self-Assembly in Materials
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac, Anesthesia and Surgical Outcomes
- Hippo pathway signaling and YAP/TAZ
- Biochemical and Structural Characterization
- Lipid Membrane Structure and Behavior
- Wnt/β-catenin signaling in development and cancer
- Crystallography and molecular interactions
- Signaling Pathways in Disease
- Growth Hormone and Insulin-like Growth Factors
Martin Luther University Halle-Wittenberg
2014-2025
University Hospital Augsburg
2022-2025
Ludwig-Maximilians-Universität München
2021-2024
LMU Klinikum
2021-2023
Heinrich Heine University Düsseldorf
2023
Universität Hamburg
2001-2021
University Medical Center Hamburg-Eppendorf
2001-2021
BQS Institut für Qualität und Patientensicherheit (Germany)
2021
Charité - Universitätsmedizin Berlin
2019
Medical University of Graz
2018
Abstract OBJECTIVES To determine the 5-year outcome in patients treated by isolated transcatheter aortic valve implantation (TAVI) or surgical replacement (sAVR)—a prospective observational cohort study. METHODS A total of 18 010 were included (n = 8942 TAVI and n 9068 sAVR) German Aortic Valve Registry (GARY) who 2011 2012 at 92 sites central Germany. Eligible with sAVR matched using propensity scores a nearest-neighbour approach. Patients repeat procedures unequivocal indication for one...
Diagnosis of primary aldosteronism (PA) for many patients depends on positive results the saline infusion test (SIT). Plasma aldosterone is often measured by immunoassays, which can return inaccurate results.This study aimed to establish whether differences in measurements immunoassay versus mass spectrometry (MS) might impact confirmatory testing PA.This study, involving 240 tested using SIT at 5 tertiary care centers, assessed discordance between and MS-based plasma aldosterone.Plasma...
Abstract Background Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, identification novel therapeutic targets an urgent need. However, tumors comprised a heterogeneous collection cells distinct genetic and molecular profiles that can differentially promote metastasis making therapy development challenging task. Here, we leveraged intratumoral heterogeneity in order to identify drivers cell...
Abstract Background Primary aldosteronism (PA) is a frequent cause of hypertension. Aldosterone excess together with high dietary salt intake aggravates cardiovascular damage, despite guideline‐recommended mineralocorticoid receptor antagonist (MRA) treatment. Objectives To investigate the antihypertensive impact moderate restriction and associated physiological changes, including mental well‐being. Methods A total 41 patients PA on stable regimen—including MRA—followed for 12 weeks...
Measurements of aldosterone by mass spectrometry are more accurate and less prone to interferences than immunoassay measurements, may produce a aldosterone:renin ratio (ARR) when screening for primary aldosteronism (PA).
Abstract Plakophilin 4 (PKP4) is a component of cell–cell junctions that regulates intercellular adhesion and Rho-signaling during cytokinesis with an unknown function epidermal differentiation. Here we show keratinocytes lacking PKP4 fail to develop cortical actin ring, preventing adherens junction maturation generation tissue tension. Instead, PKP4-depleted cells display increased stress fibers. PKP4-dependent RhoA localization at AJs was required activate RhoA-ROCK2-MLCK-MLC2 axis...
Plakophilin 3 (PKP3) is a component of desmosomes and frequently overexpressed in cancer. Using keratinocytes either lacking or overexpressing PKP3, we identify signaling axis from ERK to the retinoblastoma (RB) protein E2F1 transcription factor that controlled by PKP3. RB are key components controlling G1/S transition cell cycle. We show PKP3 stimulates activity its target RSK1. This inhibits expression RUNX3, positive regulator CDK inhibitor CDKN1A/p21, which also downregulated Elevated...
Context Primary aldosteronism (PA) causes left ventricular hypertrophy (LVH) via hemodynamic factors and directly by aldosterone effects. Specific treatment mineralocorticoid receptor antagonists (MRA) or adrenalectomy (ADX) has been reported to improve LVH. However, the cardiovascular benefit could depend on plasma renin concentration (PRC) in patients MRA. Patients objective We analyzed data from 184 Munich center of German Conn’s Registry, who underwent echocardiography at time diagnosis...
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Accumulating evidence suggests that primary aldosteronism (PA) is associated with several features of the metabolic syndrome, in particular obesity, type 2 diabetes mellitus, and dyslipidemia. Whether these manifestations are primarily linked to aldosterone-producing adenoma (APA) or bilateral idiopathic hyperaldosteronism (IHA) remains unclear. The aim present study was investigate differences parameters between APA IHA patients assess impact treatment on clinical characteristics.We...
Cortisol measurements are essential for the interpretation of adrenal venous samplings (AVS) in primary aldosteronism (PA). cosecretion may influence AVS indices. We aimed to investigate whether cortisol affects non-adrenocorticotrophic hormone (ACTH)-stimulated results.Retrospective cohort study at a tertiary referral center.We analyzed 278 PA patients who underwent non-ACTH-stimulated and had undergone least 1-mg dexamethasone suppression test (DST). Subsets additional late-night salivary...
The Hippo signaling pathway is an important regulator of organ growth and differentiation, its deregulation contributes to the development cancer. activity downstream targets YAP/TAZ depends on adherens junctions. Plakophilin 4 (PKP4) a cell-type specific junction protein expressed in proliferating cells epidermis. Here, we show that PKP4 diminishes proliferation as well differentiation. Depletion increased but at same time induced premature epidermal interacted with several components,...
Circadian rhythms have been shown to influence learning and memory. In this study, cognitive functions of Djungarian hamsters revealing different circadian phenotypes were evaluated using a novel object recognition (NOR) task. Wild type (WT) animals show clear well-synchronized daily activity rhythm, whereas DAO are characterized by delayed onset. The phenomenon is caused diminished ability photic synchronization. arrhythmic (AR) hamsters, the suprachiasmatic nuclei (SCN) do not generate...
Circadian rhythms are highly important not only for the synchronization of animals and humans with their periodic environment but also fitness. Accordingly, disruption circadian system may have adverse consequences. A certain number in our breeding stock Djungarian hamsters episodically active throughout day. Also body temperature melatonin lack 24-h rhythms. Obviously these animals, suprachiasmatic nuclei (SCN) as central pacemaker do generate a signal. Moreover, so-called arrhythmic (AR)...
Abstract OBJECTIVES Functional mitral regurgitation (FMR) is a sequel of left ventricular (LV) remodelling in heart failure patients. Relocation both papillary muscles aims to specifically address leaflet tethering improve long-term durability modern FMR repair. Nevertheless, the prognostic impact underlying cardiomyopathy on outcome after repair unknown. METHODS We analysed 84 consecutive patients with severe FMR, LV ejection fraction <40%, end-diastolic diameter ≥55 mm and tenting...
Abstract Context An important clinical feature of Cushing’s syndrome (CS) is proximal muscle myopathy caused by glucocorticoid induced protein metabolism. However, interindividual differences cannot be explained solely the pure extent hypercortisolemia. Objective To evaluate effects receptor (GR) polymorphisms (BclI, N363S, ER22/23EK and A3669G), which influence peripheral sensitivity on muscular function in endogenous CS. Methods 205 patients with proven CS (128 central, 77 adrenal) from 3...
Desmosome remodeling is crucial for epidermal regeneration, differentiation and wound healing. It mediated by adapting the composition, post-translational modifications, of constituent proteins. We have previously demonstrated in mouse suprabasal keratinocytes that plakophilin (PKP) 1 mediates strong adhesion, which negatively regulated insulin-like growth factor (IGF1) signaling. The importance PKP3 adhesion incompletely understood. Here, we identify a major role (EGF), but not IGF1,...
Abstract Context Primary aldosteronism (PA) is associated with impaired quality of life (QoL). Autonomous cortisol cosecretion (ACS) a relevant phenotype PA, which could contribute to depression and anxiety disorders. This has not been investigated so far. Objective To evaluate the prevalence in PA patients according ACS. Methods We performed testing for hypercortisolism evaluated anxiety, QoL by self-rating questionnaires newly diagnosed German Conn’s Registry; 298 were reevaluated at...
We aimed to determine the rate and impact of post-pericardiotomy syndrome after native valve-sparing aortic valve surgery perioperative factors associated with its occurrence.
Abstract Context Sampling of blood in the supine position for diagnosis pheochromocytoma and paraganglioma (PPGL) results lower rates false positives plasma normetanephrine than seated sampling. It is unclear how inpatient vs outpatient testing other preanalytical factors impact positives. Objective We aimed to identify precautions minimize false-positive metanephrines. Methods Impacts different sampling conditions on metanephrines were evaluated, including testing, semi- fully recumbent...
In about half the cases of involuntary childlessness, a male infertility factor is involved. The PIWI-LIKE genes, subclade Argonaute protein family, are involved in RNA silencing and transposon control germline. Knockout murine Piwi-like 1 2 homologs results complete males. aim this study was to analyze whether mRNA expression human 1–4 genes altered ejaculated spermatozoa men with impaired sperm characteristics. Ninety participants were included study, among which 47 normozoospermia, 36...