A5073925835- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Blood Pressure and Hypertension Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pituitary Gland Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Hormonal and reproductive studies
- Medication Adherence and Compliance
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cancer, Hypoxia, and Metabolism
- Electrolyte and hormonal disorders
- Thyroid Disorders and Treatments
University of Turin
2020-2024
Hôpital Européen Georges-Pompidou
2023
Université Paris Cité
2023
Assistance Publique – Hôpitaux de Paris
2023
Primary aldosteronism (PA) is caused by autonomous aldosterone overproduction and characterised uncontrolled hypertension. There are currently no treatments that target synthesis. We evaluated the safety efficacy of a novel synthase inhibitor, dexfadrostat phosphate, in patients with PA.
Abstract Context Primary aldosteronism (PA) comprises unilateral (lateralized [LPA]) and bilateral disease (BPA). The identification of LPA is important to recommend potentially curative adrenalectomy. Adrenal venous sampling (AVS) considered the gold standard for PA subtyping, but procedure available in few referral centers. Objective To develop prediction models subtype diagnosis using patient clinical biochemical characteristics. Design, Patients Setting referred a tertiary hypertension...
Abstract Context The diagnostic work-up of primary aldosteronism (PA) includes screening and confirmation steps. Case is time-consuming, expensive, there no consensus on tests thresholds to be used. Diagnostic algorithms avoid confirmatory testing may useful for the management patients with PA. Objective Development validation models confirm or exclude PA diagnosis in a positive test. Design, Patients, Setting We evaluated 1024 who underwent were developed training cohort (n = 522), then...
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Objective Adrenal venous sampling (AVS) is the gold standard to discriminate patients with unilateral primary aldosteronism (UPA) from bilateral disease (BPA). AVS technically demanding and in cases of unsuccessful cannulation adrenal veins, results may not always be interpreted. The aim our study was develop diagnostic models distinguish UPA BPA, successful presence contralateral suppression aldosterone secretion. Design Retrospective evaluation 158 referred a tertiary hypertension unit who...
Previous studies suggested that patients affected by primary aldosteronism (PA) have impaired quality of life (QOL) compared to the general population, but a direct comparison with essential hypertension (EH) has never been performed. The aim study was compare QOL PA EH.We designed prospective observational comparing and carefully matched EH before after treatment. We recruited 70 EH, for age, sex, blood pressure levels intensity antihypertensive assessed at baseline specific treatment or...
Objective: In experimental animal models a significant association between exogenous aldosterone excess and the progression of renal disease has been observed. However, evidence an increased risk damage in patients affected by primary aldosteronism (PA) remains controversial. We aimed to assess relationship PA, target organ its reversibility, synthesizing available from prospective retrospective observational studies, through meta-analysis. Design method: searched MEDLINE, EMBASE, Cochrane...
Reduced or absent compliance to anti-hypertensive treatment is a major obstacle the achievement of blood pressure target in patients with arterial hypertension. Current available methods for therapeutic adherence assessment display low accuracy, limited applicability clinical practice and/or high costs. We designed prospective study evaluate accuracy serial measurement ARR assess RAAS inhibitors. prospectively enrolled 80 subjects: 40 hypertension and normotensive controls. The was evaluated...
Objective: Treatment with mineralocorticoid receptor antagonists is recommended for patients bilateral forms of primary aldosteronism or unilateral unwilling unable to undergo surgery, using spironolactone as the choice, a suggested dose 1 2 mg/Kg/day. In clinical practice, however, prescribed has been progressively decreased achieve better tolerance drug and, consequently, higher compliance treatment. Our aim was evaluate how lowering could have impacted on arterial blood pressure control...
Objective: Hypertensive pregnancy disorders, affecting 4 - 25% of pregnancies according to countries’ income, represent a major cause maternal and fetal morbidity mortality. Data on pregnancy's complications in patients with primary aldosteronism (PA) are scarce, despite PA being the most frequent secondary hypertension. We did an international survey collect pregnancy-related cohort women recruited from 5 Hypertension Excellence Centers Europe. Design method: included consecutive aged 18 45...
Current guidelines recommend screening for PA in patients with hypertension on the basis of individual factors, that considered together are present more than 50% patients. Recently, some experts proposed to further expand all hypertension, potentially increasing burden and costs health care system.We designed a study build validate prediction models based supervised learning conventional scoring system define risk arterial tailor diagnostic workup each patient.We developed clinical score...
Inadequate adherence to anti-hypertensive prescription is one of the major obstacles for blood pressure control in patients with arterial hypertension. It estimated that 40% hypertension have partial or absent compliance, more than 80% non-adherence when targets are not achieved. However, clinical practice assessment therapeutic still challenging. The available methods compliance costly, low accurate time consuming.We designed a prospective observational study evaluate inhibitors...