A5068930350- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Hemodynamic Monitoring and Therapy
- Dialysis and Renal Disease Management
- Sodium Intake and Health
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Acute Kidney Injury Research
- Renal function and acid-base balance
- Chronic Kidney Disease and Diabetes
- Urticaria and Related Conditions
- Thermoregulation and physiological responses
- Climate Change and Health Impacts
- MRI in cancer diagnosis
- Cystic Fibrosis Research Advances
- Body Composition Measurement Techniques
- Lysosomal Storage Disorders Research
- Congenital Heart Disease Studies
- Animal Virus Infections Studies
- Lung Cancer Treatments and Mutations
- Spinal Cord Injury Research
- Influenza Virus Research Studies
- Erythropoietin and Anemia Treatment
- Obesity, Physical Activity, Diet
University of Lausanne
2019-2025
Hippocration General Hospital
2018-2025
Hôpital Orthopédique de la Suisse Romande
2024
University Hospital of Lausanne
2022-2023
Ippokrateio General Hospital of Thessaloniki
2023
National and Kapodistrian University of Athens
2018-2021
Chania General Hospital ”St. George”
2008-2015
Primary aldosteronism (PA) is caused by autonomous aldosterone overproduction and characterised uncontrolled hypertension. There are currently no treatments that target synthesis. We evaluated the safety efficacy of a novel synthase inhibitor, dexfadrostat phosphate, in patients with PA.
Abstract Background Zinc deficiency is commonly encountered in chronic kidney disease (CKD). The aims of this study were to assess whether zinc was related increased renal excretion and the progression CKD. Methods Plasma 24-h urinary levels, electrolytes uromodulin measured 108 CKD patients 81 individuals without Serum creatinine values collected for 3 years calculate yearly change estimated glomerular filtration rate (eGFR). Multivariable regression analysis performed association between...
Background Arterial hypertension is characterized by microvasculature changes and reduced tissue perfusion. It unknown whether a sexual dimorphism of renal microcirculation present in patients with arterial hypertension. We aimed to compare the cortical women men evaluate their response sympathetic stimulation cold pressor test (CPT). Methods The perfusion index (PI) measured contrast‐enhanced ultrasonography was used as proxy microcirculation. PI at rest during 2‐minute CPT linear...
Lifestyle and dietary modifications are unanimously suggested as the initial step to treat hypertension in general population patients with chronic kidney disease (CKD). Limiting sodium intake constitutes cornerstone of interventions, but augmenting potassium has also been associated a significant blood pressure (BP)-lowering effect. Although there may be consensus about restraining daily <2 g per day, target for optimal is vague. In hypertensive CKD, desired amount diet remains...
Increased frequency of microsatellite DNA instability (MSI) has been detected in the sputum chronic obstructive pulmonary disease (COPD) patients. The aim present study was to investigate relationship between MSI cells and exacerbation frequency, which is an important parameter clinical course disease. Induced samples peripheral blood obtained from 36 patients with COPD at stable state were analysed. control group consisted 30 nonsmoking healthy subjects. extracted analysed for using...
(1) Background: The renal microcirculation is essential to maintain the function, but its determinants in humans have been poorly studied. Contrast-enhanced ultrasound (CEUS) allows non-invasive quantification of cortical micro-perfusion at bedside using perfusion index (PI). aims this study were assess whether differences exist PI between healthy males and females identify clinical associated with micro-perfusion. (2) Methods: Healthy, normotensive volunteers (eGFR > 60 mL/min/1.73 m2, no...
Microvascular structural alteration and dysfunction is a hallmark of arterial hypertension. So far, the visualization quantification renal microcirculation in humans has been hampered by lack non-nephrotoxic non-invasive radiologic techniques. Contrast-enhanced ultrasonography (CEUS) an appealing method to investigate not investigated this setting. We aimed compare normotensive (NT) hypertensive (HT) participants using CEUS at rest during sympathetic stress test.
May Measurement Month (MMM) is an international screening campaign for arterial hypertension (HT) organised by the International Society of Hypertension and World League. It aims at raising awareness elevated blood pressure (BP) in population. The goal this analysis was to assess results obtained Swiss pharmacies during a 3-year campaign.Swiss data from MMM17 MMM19 campaigns were extracted global MMM database. conducted specifically on measures taken pharmacies. BP questionnaire including...
Hemoperfusion has been considered a promising adjuvant treatment for chronic diseases and some acute states when specific removal of pathogenic factors from the bloodstream is desired. Over years, advances in adsorption materials (e.g., new synthetic polymers, biomimetic coating, matrixes with novel structures) have renewed scientific interest expanded potential therapeutic indications hemoperfusion. There growing evidence to suggest prominent place hemoperfusion as an setting sepsis or...
Background Renal microcirculation is essential for regulation of the glomerular filtration rate, reabsorption salt and water from interstitium, hence blood pressure. ultrasonography coupled to Doppler analysis contrast-enhanced ultrasound enables study renal perfusion. So far, physiologic interventions have rarely been performed assess The objective our was measure perfusion in response a cold pressor test (CPT). Methods Healthy adult participants were exposed 2 min CPT or sham exposure...
Abstract Objective We conducted this study among school adolescents to identify factors, which influence schoolchildren smoke. Methods carried out a cross‐sectional in sample of 924 students all classes (ages 12–18 years old) 15 public high schools semi‐urban area Crete, Greece, using questionnaire. The questionnaire comprised 46 questions covering children's lifestyle habits regarding daily activities and leisure time, frequency risk‐taking behaviour, knowledge about the hazards long‐term...
Background: Accurate blood pressure (BP) measurement is essential for the correct diagnosis and management of hypertension (HTN) especially in elderly population. As with all BP devices, accuracy cuffless devices must be verified. This study (NCT04027777) aimed to evaluate performance a wrist optical device an population cohort different body positions auscultation as reference measurement.
<b><i>Introduction:</i></b> The measurement of renal functional reserve (RFR) can unmask glomerular hyperfiltration in residual nephrons, but its determination is time-consuming. In this study, we assessed whether contrast-enhanced ultrasound (CEUS) a valuable alternative to the gold standard inulin clearance and L-arginine or protein shakes lead similar changes filtration rate (GFR) as animal proteins men women. <b><i>Methods:</i></b> Changes...
Objective: Arterial hypertension is associated with alterations in the morphology and function of microvascular structure. Whether these changes are sex-specific kidney hypertensive patients unknown. Contrast-enhanced ultrasonography (CEUS) enables quantification renal microcirculation. The objective this study was to compare cortical microcirculation (HT) women versus HT men, assess response a cold pressure test (CPT). Design method: This prospective observational study. Hypertensive...
Hyperkaliemia is a relatively common electrolyte disorder whose manifestations and consequences can be serious if severe hyperkalemia not treated. In the context of hypertension, it important to look for co-morbidities conditions favoring hyperkaliemia, review drugs prescribed that could contribute potassium elevation bear in mind when causes have been excluded, genetic origin may present. this article, focus on association hypertension marketing new cardiovascular renal induce...
Abstract Background Cuffless blood pressure (BP) monitoring devices are emerging as powerful tools for BP and management of hypertension, particularly in the elderly, whom prevalence hypertension is high. Some cuffless monitors allow hourly daily tracking pressure. It remains unclear, however, whether yield equivalent performance across age categories. Purpose To compare measurements conducted by a monitor different body positions adult elderly participants with wide range levels. Methods 2...
Abstract Background/introduction Renal Functional Reserve (RFR) stands as a subject of significant scientific discussion,holding promise diagnostic tool for early detection subclinical renal disorders. Literature establishes link between chronic kidney disease & cardiovascular (CVD). Purpose This study aims to assess RFR in patients with coronary microvascular dysfunction (CMD), while maintaining preserved function (eGFR≥60ml/min/1.73m2 by CKD-EPI...
Heart failure is increasingly prevalent and estimated to increase its burden in the following years. A well-reported comorbidity of heart renal dysfunction, where predominantly changes patient’s volume status, tubular necrosis or other mechanical neurohormonal mechanisms seem drive this impairment. Currently, there are established biomarkers evaluating clinical status solely regarding cardiovascular system. However, as coexistence common related increased mortality hospitalization for...