A5004886233- Gestational Diabetes Research and Management
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Mobile Health and mHealth Applications
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Pregnancy and preeclampsia studies
- Metabolism, Diabetes, and Cancer
- COVID-19 Clinical Research Studies
- Sodium Intake and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Birth, Development, and Health
- Breastfeeding Practices and Influences
- Obesity, Physical Activity, Diet
- Obesity and Health Practices
- Dialysis and Renal Disease Management
- Psychosomatic Disorders and Their Treatments
- Vitamin D Research Studies
- Body Composition Measurement Techniques
- Diabetes Treatment and Management
- Diabetes Management and Research
- Pancreatic function and diabetes
German Center for Diabetes Research
2017-2024
Helmholtz Zentrum München
2017-2024
Heinrich Heine University Düsseldorf
2020-2024
Deutsches Diabetes-Zentrum e.V.
2020-2024
LMU Klinikum
2016-2022
Ludwig-Maximilians-Universität München
2016-2022
Klinikum rechts der Isar
2022
Technical University of Munich
2022
München Klinik
2019
Abstract Background Primary aldosteronism (PA) is a frequent cause of hypertension. Aldosterone excess together with high dietary salt intake aggravates cardiovascular damage, despite guideline‐recommended mineralocorticoid receptor antagonist (MRA) treatment. Objectives To investigate the antihypertensive impact moderate restriction and associated physiological changes, including mental well‐being. Methods A total 41 patients PA on stable regimen—including MRA—followed for 12 weeks...
Women after gestational diabetes mellitus (GDM) are a risk group for cardiometabolic diseases but hard to reach by conventional lifestyle programs. Therefore, we tested whether novel, smartphone-delivered intervention, TRIANGLE, is accepted women GDM and alters behaviors outcomes. TRIANGLE targets gradual habit change of mind emotion, physical activity, nutrition, sleep.
Low physical fitness (PF) is a risk factor for type 2 diabetes mellitus (T2D). Women with history of gestational (GDM) are at T2D young age, but the role PF in this population not clear. has also been found to correlate inversely plasma leptin previous studies. Here, we examine whether women who had GDM have lower than after normoglycemic pregnancy and, second, associated leptin, independently body fat mass.Cross-sectional analysis 236 participants PPSDiab Study (cohort study 3-16 months...
Introduction Ten years ago, Germany started offering screening for gestational diabetes mellitus (GDM) to all pregnant women. This approach revealed more but also, on average, less severe cases of GDM than the risk-based practiced previously. We now examined incidence pre-diabetes and following a diagnosis in era universal compared our results with studies previous period. Additionally, we year-to-year fluctuations glucose tolerance after pregnancy complicated by GDM. Research design methods...
Objective The occurrence of pneumonia separates severe cases COVID-19 from the majority with mild disease. However, factors determining whether or not develops remain to be fully uncovered. We therefore explored associations several lifestyle signs in COVID-19. Methods Between May and July 2020, we conducted an online survey 201 adults Germany who had recently gone through COVID-19, predominantly as outpatients. Of these, 165 a PCR-based diagnosis 36 retrospective by antibody testing....
Gestational diabetes mellitus (GDM) is the most common complication during pregnancy and associated with an increased risk for development of cardiometabolic diseases. Behavioral interventions can reduce this risk, but current solutions insufficiently address requirements such a program. The systematic scalable mobile health (mHealth) promotion program mothers first years post-GDM may contribute to solving problem.The aim project was systematically plan develop theory- evidence-based mHealth...
Abstract Objective Clinically, type 2 diabetes mellitus (T2DM) is heterogeneous, but the prevailing pathophysiologic hypothesis nevertheless contends that components of metabolic syndrome are central to all cases T2DM. Here, we re-evaluated this hypothesis. Research Design and Methods We conducted a cross-sectional analysis 138 women from monocenter, post gestational study PPSDiab, 73 which had incident prediabetes or Additionally, examined 412 T2DM in phases 3 9 Whitehall II comparison...
Abstract Objective Many anecdotal reports indicate the presence of ‘long COVID’ – COVID-19-related symptoms weeks to months after acute illness. However, frequency and symptom-pattern in relation disease severity are uncertain. As part an ongoing, prospective cohort study we therefore conducted online survey among adults 6 COVID-19. Methods The Life&Covid is ongoing Germany since May 2020. Participants were recruited 0 4 their SARS-CoV-2 infection und followed up by subsequent surveys....
The myokine myostatin regulates muscle mass and has been linked to insulin resistance metabolic syndrome. However, data on its role in humans is still limited. We, therefore, investigated the associations of serum with mass, physical fitness, components syndrome a cohort premenopausal women.We undertook cross-sectional analysis 233 women from monocenter study PPSDiab, conducted Munich, Germany. Participants had recently completed pregnancy or without gestational diabetes. Our included...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Background High dietary sodium intake is a major cardiovascular risk factor and adversely affects blood pressure control. Patients with primary aldosteronism (PA) are at increased risk, even after medical treatment, high common in these patients. Here, we analyze the impact of moderate restriction on microbiome composition immunophenotype patients PA. Methods Prospective two-stage clinical trial including two subgroups: 15 treatment-naive PA compared to matched normotensive controls; 31...
Zusammenfassung Ein Schwangerschaftsdiabetes zeigt ein deutlich erhöhtes Risiko für die spätere Entwicklung eines Typ-2-Diabetes an 1. Eine gesundheitsfördernde Lebensweise kann dieses senken 2,3 ist aber junge Mütter schwierig umzusetzen. Traditionelle Lebensstilberatung bleibt in dieser Gruppe meist erfolglos 4. Die Präventions-App TRIANGLE soll diese Versorgungslücke schließen.
Abstract Objective The occurrence of pneumonia separates severe cases COVID-19 from the majority with mild disease. However, factors determining whether or not develops remain to be fully uncovered. We therefore explored associations several lifestyle signs in COVID-19. Methods Between May and July 2020, we conducted an online survey 201 adults Germany who had recently gone through COVID-19, predominantly as outpatients. Of these, 165 a PCR-based diagnosis 36 retrospective by antibody...
Skeletal muscle contributes significantly to insulin sensitivity in humans. However, which non-invasive measurement best reflects this contribution remains unknown. Consequently, paper compares morphologic and functional measurements.
Background/objective Type 2 diabetes related to metabolic syndrome is often partially reversible after weight loss. We conducted a pilot trial on whether complete remission the point of normalized real-life glucose profile, measured by continuous subcutaneous monitoring, can be achieved. Methods mono-center, single-arm intervention between January 20, 2020, and 12, 2021, in Munich, Germany. Ten participants had type for maximum six years. They received six-month lifestyle including up three...
<sec> <title>BACKGROUND</title> Gestational diabetes mellitus (GDM) is the most common complication during pregnancy and associated with an increased risk for development of cardiometabolic diseases. Behavioral interventions can reduce this risk, but current solutions insufficiently address requirements such a program. The systematic scalable mobile health (mHealth) promotion program mothers first years post-GDM may contribute to solving problem. </sec> <title>OBJECTIVE</title> aim project...
Hintergrund: Hohes Plasma-Fetuin-A ist ein Risikomarker für Typ 2 Diabetes. Wir konnten bereits zeigen, dass Fetuin-A auch bei Frauen mit einer GDM-Anamnese erhöht ist. Hier untersuchen wir die Frage, inwieweit in unserer Studienkohorte Zusammenhang zwischen dem Fetuin-A-Spiegel und körperlicher Fitness besteht.
Hintergrund und Fragestellung: Erhöhte Leptinspiegel sind assoziiert mit Adipositas, Metabolischem Syndrom, Typ-2-Diabetes zentraler Leptinresistenz. In der PPS-Diab-Kohorte, konnten wir bei Frauen im ersten Jahr nach einer Schwangerschaft, ohne Gestationsdiabetes (GDM), bereits zeigen, dass Plasmaleptin BMI-unabhängig negativ Insulinempfindlichkeit korreliert. Hier untersuchten nun die Frage, ob in derselben Kohorte ein Zusammenhang zwischen körperlicher Leistungsfähigkeit, gemessen als...
Hintergrund/Zielsetzung: Frauen nach Gestationsdiabetes (GDM) haben ein stark erhöhtes Risiko, an Typ-2 Diabetes (T2D) zu erkranken. Lebensstilfaktoren tragen dieser Prädisposition bei. Bisherige Publikationen und die Daten einer von uns durchgeführten prospektiven Kohortenstudie (PPS-Diab) weisen darauf hin, dass hierbei insbesondere drei Bereiche Stressbewältigung/Schlaf, Ernährung Bewegung wichtig sind. Basierend auf diesen Ergebnissen unter Berücksichtigung der speziellen Lebenssituation...
Objective: The relationship between high dietary salt intake and blood pressure is well established. Recommendations for restriction have found their way into major guidelines essential hypertension. Patients with primary aldosteronism (PA), the most common endocrine cause of arterial hypertension, are believed to be exquisitely sensitive, i.e., respond particularly restriction. However, surprisingly little efforts been made determine precise impact in patients PA. We, therefore, set out...
Die Plasmaspiegel einiger Aminosäuren können bei (Prä-)Diabetikern verändert sein. Datenlage ist aber uneinheitlich und die klinische Relevanz von für Diagnose oder Prädiktion Typ-2-Diabetes (T2D) unklar. Wir fassen hier aktuelle Literatur zu diesem Thema zusammen präsentieren neue, bisher unpublizierte Daten aus der PPSDiab-Studie, einer Kohortenstudie junger Frauen.