A5017941012- Linguistics and Cultural Studies
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cyprus History, Politics, Society
- Turkish Literature and Culture
- Cultural and Sociopolitical Studies
- Byzantine Studies and History
- Linguistics, Language Diversity, and Identity
- Cell death mechanisms and regulation
- Linguistics and language evolution
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Balkans: History, Politics, Society
- Cancer Immunotherapy and Biomarkers
- Classical Antiquity Studies
- Contemporary and Historical Greek Studies
- Historical and Linguistic Studies
- Virus-based gene therapy research
- Families in Therapy and Culture
- Ancient Mediterranean Archaeology and History
- Eurasian Exchange Networks
- MicroRNA in disease regulation
Martin Luther University Halle-Wittenberg
2016-2025
Ludwig-Maximilians-Universität München
2002-2023
Patan Academy of Health Sciences
2023
Panagiotis & Aglaia Kyriakou Children's Hospital
2023
National and Kapodistrian University of Athens
2023
Sotiria General Hospital
2023
Imperial College London
2023
Ca' Foscari University of Venice
2011-2022
University Hospital in Halle
2020-2021
Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
2017-2020
Evaluation of T lymphocyte frequency provides prognostic information for patients with oral squamous cell cancer (OSCC). However, the effect simultaneously evaluating and assessing suppressive elements defects in antigen-processing machinery (APM) has not been clarified. Simultaneous characterization CD3+, CD8+, FoxP3+, CD163+, PD-L1+ cells using multispectral imaging was performed on sections from 119 HPV- OSCC. Expression β2-microglobulin, MHC class I heavy chain, large multifunctional...
Hypoxia induces activation of the HIF-1 pathway and is an essential characteristic malignant gliomas. has been linked to tumor progression, therapy resistance poor prognosis. However, little known about impact HIF-1α inhibition on radioresistance glioma.In this study, we investigated effects cell survival radiosensitivity in U251MG U343MG glioma cells, using two different strategies. was achieved by siRNA targeting or via chetomin, a disruptor interactions between p300. The monitored...
The aim of this monograph is to provide a detailed account language policy and planning in Cyprus. Using both historical synchronic data adopting mixed-methods approach (archival research, ethnographic tools insights from sociolinguistics Critical Discourse Analysis), study attempts trace the origins trajectories polices Cyprus relate these issues ethnicity, community national identity formation, maintenance shift, as well varying constructions role education. It will be shown that, while...
Survivin, a recently identified inhibitor of apoptosis protein (IAP), is expressed in diverse embryonic tissues and various human cancers. We have investigated the quantitative expression survivin mRNA by sensitive TaqMan-based RT-PCR assay tissue samples from 94 patients with soft sarcomas (STS). Survivin transcript levels were measured normalized to GAPDH transcripts. By using multivariate Cox regression analysis, we found an inverse correlation between level (ratio >2 zmol survivin/amol...
The product of the HDMX (or MDM4) gene is structurally related to MDM2 oncoprotein and also capable interacting with tumor suppressor protein p53. aim our study was determine amplification status expression mRNA (particularly that HDMX-S splice variant) in soft-tissue sarcomas (STS). Patients STS were evaluated for (n = 66) 57) within their tumors. DNA, total RNA isolated from frozen tissue. We determined variant transcript predominant a subset (14%) samples its correlated decreased patient...
Expression of microRNAs can affect age tumor onset and prognosis cancer patients. However, nothing is known about the effects on altered disease-specific survival soft-tissue sarcoma (STS) The levels miR-210, also as hypoxia-regulated microRNA, were analyzed by quantitative real-time (RT)-PCR in tumors 78 STS patients stratified according to their microRNA with low, intermediate high expression association patients' was using multivariate Cox's regression hazard analyses. A significant...
Abstract Background Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, identification novel therapeutic targets an urgent need. However, tumors comprised a heterogeneous collection cells distinct genetic and molecular profiles that can differentially promote metastasis making therapy development challenging task. Here, we leveraged intratumoral heterogeneity in order to identify drivers cell...
Oral squamous cell carcinoma (OSCC), a major subgroup of head and neck (HNSCC), is an aggressive disease that preferentially spreads to cervical lymph nodes. Positive node status important predictor survival in OSCC [1-3]. Hence, better understanding the molecular mechanisms underlying oral cancer metastasis identification therapeutic vulnerabilities are needed prevent treat metastatic disease. We collected 87 primary tumors 21 (LNM) from 72 patients conduct comprehensive transcriptome-wide...
Abstract Background Studies on procalcitonin (PCT) for identifying sepsis were published as early 1993 and since then, PCT has been the topic of over 8,500 studies. Several studies show to be superior CRP in differentiating invasive infections such from viral infections, especially disease course. However, its actual use clinical practice is poorly documented. Our aim was study febrile children attending ED across Europe compare this CRP. Methods The MOFICHE/PERFORM study, a prospective...
The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression the result of mechanisms, for example, enhanced transcription or translation, amplification alternative splicing. We found 19 67 (28.4%) STS specimens contained an amplified gene. was more likely to be present grade 1 tumors than 2 3 (58% vs. 15% tumors, p = 0.001, chi(2) test). Furthermore, patients with had survival...