A5039510283- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Emergency and Acute Care Studies
- Aquaculture disease management and microbiota
- Pharmaceutical and Antibiotic Environmental Impacts
- Pneumonia and Respiratory Infections
- Kawasaki Disease and Coronary Complications
- Antibiotic Resistance in Bacteria
- Financial Markets and Investment Strategies
- Neonatal and Maternal Infections
- Methane Hydrates and Related Phenomena
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Sepsis Diagnosis and Treatment
- Respiratory viral infections research
- Gut microbiota and health
- Child Welfare and Adoption
- Neonatal Respiratory Health Research
- Capital Investment and Risk Analysis
- Hematological disorders and diagnostics
- Global Healthcare and Medical Tourism
- Environmental DNA in Biodiversity Studies
- Multiple and Secondary Primary Cancers
- Simulation-Based Education in Healthcare
University of Exeter
2021-2025
Rockefeller University
2024
Institut des Maladies Génétiques Imagine
2024
Université Paris Cité
2024
University of Manitoba
2024
Inserm
2024
Great North Children's Hospital
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Sotiria General Hospital
2023
Panagiotis & Aglaia Kyriakou Children's Hospital
2023
Despite the growing popularity of cosmetic procedures, sociocultural and quality-of-life factors that motivate patients to undergo such procedures are not well understood. To estimate relative importance seek minimally invasive procedures. This prospective, multicenter observational study was performed at 2 academic 11 private dermatology practice sites represented all US geographic regions. Adult presenting for consultation or treatment from December 4, 2016, through August 9, 2017, were...
Food production environments in low- and middle-income countries (LMICs) are recognized as posing significant increasing risks to antimicrobial resistance (AMR), one of the greatest threats global public health food security systems. In order maximize expedite action mitigating AMR, World Bank AMR Global Leaders Group have recommended that is integrated into wider sustainable development strategies. Thus, there an urgent need for tools support decision makers unravelling complex social...
Differentiating between self-resolving viral infections and bacterial in children who are febrile is a common challenge, causing difficulties identifying which individuals require antibiotics. Studying the host response to infection can provide useful insights lead identification of biomarkers with diagnostic potential. This study aimed identify protein for future development into an accurate, rapid point-of-care test that distinguish infections, by recruiting presenting health-care settings...
Abstract The skin of fish contains a diverse microbiota that has symbiotic functions with the host, facilitating pathogen exclusion, immune system priming, and nutrient degradation. composition microbiomes varies across species in response to variety stressors, however, there been no systematic analysis these studies evaluate how factors shape microbiomes. Here, we examined 1922 from 36 included 98 nine rearing conditions investigate associations between microbiome, species, water...
In Bangladesh, fish provide over 60% of animal-source food with 56.2% this coming from aquaculture produced predominantly in rural freshwater ponds. Increasing demand for products is driving intensification and resulting higher disease prevalence, posing a risk to security. Biosecurity often absent practices Bangladesh antibiotics are commonly used treat prevent outbreaks. Antibiotics administered incorrectly - key factor associated the development antimicrobial resistance (AMR). AMR can be...
Dominant microorganisms of the Sargasso Sea are key drivers global carbon cycle. However, associated viruses that shape microbial community structure and function not well characterised. Here, we combined short long read sequencing to survey phage communities in virus- cellular fractions at viral maximum (80 m) mesopelagic (200 depths. We identified 2,301 populations from 186 genera. Over half here lacked representation ocean metagenomes, whilst 177 genera genomic databases isolates. Viral...
Abstract Background Studies on procalcitonin (PCT) for identifying sepsis were published as early 1993 and since then, PCT has been the topic of over 8,500 studies. Several studies show to be superior CRP in differentiating invasive infections such from viral infections, especially disease course. However, its actual use clinical practice is poorly documented. Our aim was study febrile children attending ED across Europe compare this CRP. Methods The MOFICHE/PERFORM study, a prospective...
Abstract Background The pondwater microbiome is believed to play a key role in fish health, including shaping mucosal surface microbiomes that help protect against disease. How different physiochemical features relating season, geographical locations, as well crop species shape the pond water finfish aquaculture system, not established. Pangasius ( Pangasianodon hypophthalmus ) and tilapia Oreochromis niloticus are two of most widely farmed disease major impediment expansion their...
Abstract The SAR11 clade are the most abundant members of surface marine bacterioplankton and a critical component global biogeochemical cycles. Similarly, pelagiphages that infect ubiquitous highly in oceans. Pelagiphages predicted to shape community structures increase carbon turnover throughout Yet, ecological drivers host niche specificity pelagiphage populations poorly understood. Here we report distribution novel called “Polarivirus skadi”, which is sole representative genus. P. skadi...
The terrestrial slug Arion subfuscus secretes a glue that is dilute gel with remarkable adhesive and cohesive strength. function of this depends on metals, raising the possibility metal-catalyzed oxidation plays role. extent time course protein was measured by immunoblotting to detect resulting carbonyl groups. Several proteins, particularly one relative molecular mass (M(r)) 165 x 10³, were heavily oxidized. Of proteins known distinguish from non-adhesive mucus, only specific size variants...
Immune monitoring in cancer immunotherapy involves screening CD8+ T-cell responses against neoantigens, the tumor-specific peptides presented by Major histocompatibility complex Class I (MHCI) on cell surface. High-throughput immune requires methods to produce and characterize small quantities of thousands MHCI–peptide complexes that may be tested for a patient's response. MHCI synthesis has been achieved using photocleavable peptide is exchanged neoantigen; however, assays measure exchange...
Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response infection. The site-specific was characterized plasma derived from well-defined controls patients. found 3862 unique features, we identified 463 distinct intact...
Abstract When people are endowed with an object, they demand more money in order to part it than would be willing pay acquire the first place. This phenomenon is known as endowment effect. From a behavioral finance point of view, effect interesting because asymmetry between people's willingness object versus seems triggered by mere ownership object. In this paper, we propose that due discrepancies affective equilibria owners and potential buyers endowment. We define equilibrium price or...
The methylotrophic OM43 clade are
Limited research has been carried out on Indigenous young people transitioning of care in Canada. This article provides a coherent and meaningful account the journey aging province Manitoba, as presented by 17 leavers. Using qualitative multilevel approach grounded first-person narratives, this study focused incorporating elevating voices Participants detailed their experiences planning for transition care, described life post-care. The leavers expressed that Child Family Services-led...
ABSTRACT The methylotrophic OM43 clade are Gammaproteobacteria that comprise some of the smallest free-living cells known and have highly streamlined genomes. represents an important microbial link 0between marine primary production remineralisation carbon back to atmosphere. Bacteriophages shape communities major drivers mortality global biogeochemistry. Recent cultivation efforts brought first viruses infecting members into culture. Here we characterize a novel myophage called Melnitz....
Introduction: Treatment of Pregnancy Associated Breast Cancer (PABC) with radiation and endocrine therapy is challenging due to potential risks the fetus. Surgical treatment safe throughout pregnancy, chemotherapy agents such as anthracyclines are during 2 nd 3 rd trimesters. Case Presentation: A 39-year-old G4P3 female presented at 8 weeks gestation a twin pregnancy right breast mass bloody nipple discharge. Past medical history was significant for obesity chronic hypertension. Biopsy...
Abstract Bacteria in the SAR11 clade are most abundant members of surface marine bacterioplankton and a critical component global biogeochemical cycles. Similarly, pelagiphages that predate both ubiquitous highly oceans. These viruses predicted to shape community structures increase carbon turnover throughout Yet, ecological drivers host niche specificity pelagiphage populations poorly understood. Here we report distribution novel called Skadi isolated from Western English Channel using...
Abstract In Bangladesh, fish provide over 60% of animal-source food with 56.2% this coming from aquaculture produced predominantly in rural freshwater ponds. Increasing demand for products is driving intensification and resulting higher disease prevalence, posing a risk to security. Biosecurity often absent practices Bangladesh antibiotics are commonly used treat prevent outbreaks. Antibiotics administered incorrectly - key factor associated the development antimicrobial resistance (AMR)....
ABSTRACT In the summer months, waters of Sargasso Sea are nutrient-limited and strongly stratified, serving as a model system for predicted warmer oceans Anthropocene. The dominant microorganisms surface key drivers global carbon cycle. However, viruses that shape these host communities influence biogeochemical function not well understood. Here, we apply hybrid sequencing approach combines short- long reads to survey phage via metagenomics at viral maximum (80m) mesopelagic (200m) depths....
During clinical experiences, physician assistant (PA) students are required to participate in the management of multiple patients simultaneously. One method preparing for experiences is through use simulation. Simulation allows development decision-making and teamwork skills. 1,2 A previous study nursing a multiple-patient simulation demonstrated improved student readiness care patients. 2 The present evaluated effect using on PA comfort with managing an emergency room setting.Four programs...