A5007319782- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Barrier Structure and Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Bacterial Identification and Susceptibility Testing
- Respiratory viral infections research
- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Streptococcal Infections and Treatments
- Neutropenia and Cancer Infections
- Genomics and Phylogenetic Studies
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Viral Infections and Outbreaks Research
- Inflammasome and immune disorders
- Pediatric health and respiratory diseases
- Complement system in diseases
- Glycosylation and Glycoproteins Research
- S100 Proteins and Annexins
- Advanced Proteomics Techniques and Applications
- Retinal Imaging and Analysis
- Viral Infections and Vectors
- Hematological disorders and diagnostics
- Retinal Diseases and Treatments
Sanquin
2018-2023
Emma Kinderziekenhuis
2018-2023
University of Amsterdam
2020-2023
National and Kapodistrian University of Athens
2023
Imperial College London
2023
Amsterdam University Medical Centers
2020-2021
Stanford University
2018-2019
Neutrophils are the most abundant innate immune cells in circulation and they first recruited to sites of infection or inflammation. Almost half intracellular protein content neutrophils consists S100A8 S100A9, though there has been controversy about their actual localization. Once released extracellularly, these proteins thought act as damage-associated molecular patterns (DAMPs), mechanism action is not well understood. These S100 mainly form heterodimers (S100A8/A9, also known...
Age-related macular degeneration (AMD) is the principal cause of blindness in elderly population. A strong effect on AMD risk has been reported for genetic variants at CFH locus, encompassing complement factor H (CFH) and complement-factor-H-related (CFHR) genes, but underlying mechanisms are not fully understood. We aimed to dissect role (FH) FH-related (FHR) proteins a cohort 202 controls 216 individuals with AMD. detected elevated systemic levels FHR-1 (p = 1.84 × 10-6), FHR-2 1.47 10-4),...
Differentiating between self-resolving viral infections and bacterial in children who are febrile is a common challenge, causing difficulties identifying which individuals require antibiotics. Studying the host response to infection can provide useful insights lead identification of biomarkers with diagnostic potential. This study aimed identify protein for future development into an accurate, rapid point-of-care test that distinguish infections, by recruiting presenting health-care settings...
Background: Kawasaki disease (KD) is a vasculitis of early childhood mimicking several infectious diseases. Differentiation between KD and diseases essential as KD's most important complication-the development coronary artery aneurysms (CAA)-can be largely avoided by timely treatment with intravenous immunoglobulins (IVIG). Currently, diagnosis only based on clinical criteria. The aim this study was to evaluate whether routine C-reactive protein (CRP) additional inflammatory parameters...
Abstract An aged circulatory environment can promote brain dysfunction and we hypothesized that the blood-brain barrier (BBB) mediates at least some of these effects. We observe endothelial cells (BECs) in mouse hippocampus express an inflammatory transcriptional profile with focal upregulation Vascular Cell Adhesion Molecule 1 (VCAM1), a protein facilitates vascular-immune cell interactions. Concomitantly, shed, soluble form VCAM1 is prominently increased circulation humans mice, plasma...