Login

Taylor Merkel

ORCID: 0000-0002-6427-8488
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
A5021073152
Research Areas
  • Neurogenesis and neuroplasticity mechanisms
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Barrier Structure and Function Studies

VA Palo Alto Health Care System
 2019

Stanford University
 2018

 Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
OPENALEX - Publications 
Hanadie Yousef Cathrin J. Czupalla Davis Lee Michelle B. Chen Ashley N. Burke and 17 more Kristy Zera Judith Zandstra Elisabeth Berber Benoit Lehallier Vidhu Mathur Ramesh V. Nair Liana Bonanno Andrew C. Yang Todd C. Peterson Husein Hadeiba Taylor Merkel Jakob Körbelin Markus Schwaninger Marion S. Buckwalter Stephen R. Quake Eugene C. Butcher Tony Wyss‐Coray

10.1038/s41591-019-0440-4 article EN Nature Medicine 2019-05-13
 Aged blood inhibits hippocampal neurogenesis and activates microglia through VCAM1 at the blood-brain barrier
OPENALEX - Publications 
Hanadie Yousef Cathrin J. Czupalla Davis Lee Ashley Burke Michelle Chen and 11 more Judith Zandstra Elisabeth Berber Benoit Lehallier Vidhu Mathur Ramesh V. Nair Liana Bonanno Taylor Merkel Markus Schwaninger Stephen R. Quake Eugene C. Butcher Tony Wyss‐Coray

Abstract An aged circulatory environment can promote brain dysfunction and we hypothesized that the blood-brain barrier (BBB) mediates at least some of these effects. We observe endothelial cells (BECs) in mouse hippocampus express an inflammatory transcriptional profile with focal upregulation Vascular Cell Adhesion Molecule 1 (VCAM1), a protein facilitates vascular-immune cell interactions. Concomitantly, shed, soluble form VCAM1 is prominently increased circulation humans mice, plasma...

10.1101/242198 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2018-01-03
Coming Soon ...