A5082094809- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Nasolacrimal Duct Obstruction Treatments
- Immune Cell Function and Interaction
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Ear and Head Tumors
- Sinusitis and nasal conditions
- CNS Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cancer and Skin Lesions
- Prostate Cancer Treatment and Research
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Oral and Maxillofacial Pathology
- Proteoglycans and glycosaminoglycans research
- Receptor Mechanisms and Signaling
- Tumors and Oncological Cases
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
Sana Klinikum Lichtenberg
2024
Martin Luther University Halle-Wittenberg
2015-2024
Halle Zoo
2022
University Hospital in Halle
2016-2021
Cancer Research Center
2017
Providence Portland Medical Center
2017
Data Harbor (United States)
2015
Abstract Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the research communities. We evaluated sources of variability sTIL assessment pathologists three previous ring studies. identify common challenges evaluate impact...
Evaluation of T lymphocyte frequency provides prognostic information for patients with oral squamous cell cancer (OSCC). However, the effect simultaneously evaluating and assessing suppressive elements defects in antigen-processing machinery (APM) has not been clarified. Simultaneous characterization CD3+, CD8+, FoxP3+, CD163+, PD-L1+ cells using multispectral imaging was performed on sections from 119 HPV- OSCC. Expression β2-microglobulin, MHC class I heavy chain, large multifunctional...
Hypoxia gene expression signatures are of high prognostic value for head and neck cancer patients. Recently, the information a multiple-gene hypoxia signature was found to be provided by mRNA level P4HA1 alone (Tawk et al., 2016). Therefore, we studied in an independent cohort oral squamous cell carcinoma (OSCC) patients.Frozen tumor samples 118 adult OSCC patients were analysed quantitative real-time TaqMan™ PCR analysis. Kaplan-Meier analysis Cox's regression performed characterize impact...
Abstract Aim In vivo vascular smooth muscle cell ( VSMC ) EGF receptor EGFR contributes to acute angiotensin II AII effects on tone and blood pressure. The ubiquitously expressed has been implicated in remodelling preceding end‐organ damage by pharmacological inhibition, signalling cultured cells is partly ‐dependent. However, the role of ‐ during ‐induced pathophysiological processes not known. Methods This study assesses relevance chronic challenge without further stressors, using a mouse...
Abstract HER3 is highly expressed in luminal breast cancer subtypes. Its activation by NRG1 promotes of AKT and ERK1/2, contributing to tumour progression therapy resistance. HER3-targeting agents that block this activation, are currently under phase 1/2 clinical studies, although they have shown favorable tolerability, their activity as a single agent has proven be limited. Here we show phosphorylation cells occurs paracrine manner mediated cancer-associated fibroblasts (CAFs). Moreover,...
Background Intratympanic injections of glucocorticoids have become increasingly common in the treatment idiopathic sudden sensorineural hearing loss (ISSHL). However, due to their fast elimination, sustained applications been suggested for local drug delivery inner ear. Materials and methods The study is based on a retrospective chart review patients treated ISSHL at single tertiary (university) referral center. We included who were with solid, biodegradable, poly(D,L-lactic-co-glycolic...
Carbonic anhydrase 9 (CAIX) is an important protein that stabilizes the extracellular pH value and transcriptionally regulated by hypoxia-inducible factor 1 (HIF1), but more stable than HIF1α. Here we show a comparative study examines prognostic of CA9 mRNA, CAIX tumor cells secreted for oral squamous cell carcinoma (OSCC) patients. Tumor samples from 72 OSCC patients 24 normal tissue were analyzed mRNA levels. A total 158 stained immunohistochemistry 89 blood serum ELISA soluble content....
The extracellular matrix protein biglycan (BGN) has oncogenic or tumor suppressive potential depending on the cellular origin. HER-2/neu overexpression in murine fibroblasts and human model systems is inversely correlated with BGN expression. Upon its restoration BGNhigh HER-2/neu+ were less tumorigenic immune competent mice when compared to BGNlow/neg cells, which was associated enhanced cell responses higher frequencies of effector cells tumors peripheral blood. increased immunogenicity...
Epi dermal growth factor (EGF) receptor (EGFR) is activated by its canonical ligands and transactivated various vasoactive substances, e.g. angiotensin II (Ang II). Vascular EGFR has been proposed to be involved in vascular tissue homoeostasis remodelling. Thus, most studies have focused on role during long-term changes whereas the relevance for acute regulation of function vivo ex insufficiently understood. To investigate postnatal VSMCs (vascular smooth muscle cells) vivo, we generated a...
Progression of oral squamous cell carcinoma (OSCC) has been associated with an escape tumor cells from the host immune surveillance due to increased knowledge its underlying molecular mechanisms and modulation by microenvironment repertoire. In this study, expression HLA class I (HLA-I) antigens components antigen processing machinery (APM) was analyzed in 160 pathologically classified human papilloma virus (HPV)-negative OSCC lesions correlated intra-tumoral response, IFN-γ signaling...
<b><i>Introduction:</i></b> Triple-negative breast cancer (TNBC) is considered the most aggressive type of (BC) with limited options for therapy. TNBC a heterogeneous disease and tumors have been classified into subtypes using gene expression profiling to distinguish basal-like 1, 2, immunomodulatory, mesenchymal, mesenchymal stem-like, luminal androgen receptor (LAR), one nonclassifiable group (called unstable). <b><i>Objectives:</i></b> The...
The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and overexpressed large number of carcinoma including colon cancer, breast cancer oral squamous carcinomas (OSCC). role the full length transcript (LGR5FL) progression prognosis several cancers was reported. However, biological function three splice variants LGR5 (LGR5Δ5, LGR5Δ8 LGR5Δ5-8) has yet to be thoroughly investigated.Seventy-eight frozen tumor samples from...
The extracellular matrix component biglycan (BGN) plays an essential role in various physiological and pathophysiological processes. A deficient BGN expression associated with reduced immunogenicity was found HER-2/neu-overexpressing cells. To determine whether is suppressed by oncogene-driven regulatory networks, the function of analyzed murine human BGNlow/BGNhigh K-RASG12V-transformed model systems as well different patients' datasets colorectal carcinoma (CRC) lesions. K-RAS-mutated CRC...
&beta;2-m, &beta;2-microglobulin; CAF, cancer associated fibroblast; CSC, stem cell; CTL, cytotoxic T lymphocyte; DC, dendritic ECM, extracellular matrix; EGF-R, epidermal growth factor receptor; ER, endoplasmic reticulum; FDA, Food and Drug Administration; HLA, human leukocyte antigen; HNSCC, head neck squamous cell carcinoma; HPV, papilloma virus; ICP immune checkpoint; ICPi, checkpoint inhibitor; IFN, interferon; LMP, low molecular weight protein; mAb, monoclonal antibody; MDSC,...
This study aimed to analyze margin status and the impact of immune elements on recurrence in patients with oral squamous cell carcinoma (OSCC), employing a prognostic biomarker, cumulative suppressive index (CSI), which reflects FoxP3+, PD-L1+, CD8+ spatial relationships tumor microenvironment.Cox proportional hazards regression was used evaluate interactive effect by CSI discrepancy (high, 3-4 vs low, 0-2) free survival (RFS) overall (OS) 119 stage I IVA OSCC.In cases negative margins,...
Progression of oral squamous cell carcinoma (OSCC) has been associated with an escape tumor cells from the host immune surveillance due to increased knowledge its underlying molecular mechanisms and modulation by microenvironment repertoire. In this study expression HLA class I (HLA-I) antigens components antigen processing machinery (APM) was analyzed in 160 pathologically classified human papilloma virus (HPV)-negative OSCC lesions correlated intra-tumoral response, IFN- signaling...
Tumour-infiltrating lymphocytes (TILs) are considered to have prognostic and predictive value for patients with early breast cancer. We examined 1166 cancer from a prospective, multicentre cohort (Prognostic Assessment in Routine Application (PiA), n = 1270, NCT01592825) following recommendations the International TILs Working Group. TIL quantification was performed using predefined groups as continuous variable 10% increments. The primary objective distribution of different types. second...