A5024265770- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Advanced Breast Cancer Therapies
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- CAR-T cell therapy research
- 3D Printing in Biomedical Research
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Nonmelanoma Skin Cancer Studies
- Breast Lesions and Carcinomas
- Gut microbiota and health
Hospital Del Mar
2010-2025
Hospital del Mar Research Institute
2013-2024
Centro de Investigación Biomédica en Red de Cáncer
2020-2024
Municipal Institute for Medical Research
2011-2023
Parc de Salut
2011-2023
Universitat Pompeu Fabra
2011-2023
Hospital Universitario Fundación Jiménez Díaz
2020
GEICAM – Spanish Breast Cancer Group
2020
Vall d'Hebron Institute of Oncology
2017
Molecular Oncology (United States)
2017
A dense mucus layer in the large intestine prevents inflammation by shielding underlying epithelium from luminal bacteria and food antigens. This barrier is organized around hyperglycosylated mucin MUC2. Here we show that small has a porous layer, which permitted uptake of MUC2 antigen-sampling dendritic cells (DCs). Glycans associated with imprinted DCs anti-inflammatory properties assembling galectin-3-Dectin-1-FcγRIIB receptor complex activated β-catenin. transcription factor interfered...
Antibody targeting of the immune checkpoint receptor PD1 produces therapeutic activity in a variety solid tumors, but most patients exhibit partial or complete resistance to treatment for reasons that are unclear. In this study, we evaluated tumor specimens from 65 with melanoma, lung nonsquamous, squamous cell head and neck cancers who were treated approved PD1-targeting antibodies pembrolizumab nivolumab. Tumor RNA before anti-PD1 therapy was analyzed on nCounter system using PanCancer...
Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM+ plasma cells (PCs) were more abundant in humans than mice and clonally related to a large repertoire of memory B disseminated throughout the intestine but rare systemic lymphoid organs. In addition sharing gut-specific gene signature with IgA+ cells, some clonotypes switched IgA response T cell-independent or cell-dependent signals. These signals induced IgM...
Abstract Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the research communities. We evaluated sources of variability sTIL assessment pathologists three previous ring studies. identify common challenges evaluate impact...
Abstract Background The variability in responses to neoadjuvant treatment with anti-HER2 antibodies prompts personalized clinical management and the development of innovative strategies. Tumor-infiltrating Natural Killer (TI-NK) cells can predict efficacy HER2-targeted independently from clinicopathological factors primary HER2-positive breast cancer patients. Understanding mechanism/s underlying this association would contribute optimizing patient stratification provide rationale for...
Abstract Tumors are complex tissues composed of transformed epithelial cells as well cancer-activated fibroblasts (CAF) that facilitate tumor cell invasion. We show here CAFs and other mesenchymal rely much more on glutamine than cells; consequently, they sensitive to inhibition glutaminase. Glutamine dependence drove CAF migration toward this amino acid when cultured in low conditions. also invaded a Matrigel matrix following concentration gradient enhanced the invasion both were...
Mechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic reconfiguration marginal zone (MZ) B cells, a pre-activated lymphocyte subset mounts antibody responses T-cell-independent antigens through Toll-like receptor (TLR)-amplified pathway involving transmembrane activator and CAML interactor (TACI). This interacts with via the TLR adapter MyD88. The resulting activation instigates MZ B-cell...
Abstract Purpose: To assess the efficacy and exploratory biomarkers of continuing palbociclib plus endocrine therapy (ET) beyond progression on prior palbociclib-based regimen in patients with hormone receptor–positive/HER2-negative (HR+/HER2−) advanced breast cancer (ABC). Patients Methods: The multicenter, open-label, phase II BioPER trial included women who had experienced a progressive disease (PD) after having achieved clinical benefit immediately ET regimen. Palbociclib (125 mg, 100 or...
Abstract Nipple discharge affects over 80% of women at some point in their lives, with malignancy detected up to 23% cases. This review highlights the shift from traditional surgical approaches advanced imaging techniques, which enhance diagnostic accuracy and reduce unnecessary procedures. Diagnosis begins a thorough medical history physical examination assess need for imaging. Physiological nipple discharge, is bilateral, multiductal, non-spontaneous, typically requires no Conversely,...
Natural killer (NK) cells can orchestrate effective antitumor immunity. The presence of tumor-infiltrating NK in diagnostic biopsies predicts pathologic complete response (pCR) to HER2-specific therapeutic antibodies patients with primary breast cancer. Here, we analyzed whether diversity circulating might influence tumor infiltration and antibody efficacy. We found that numbers CD57+ inversely correlated pCR treatment cancer independently age, traditional clinicopathologic factors, CD16A...
Abstract Enhancing natural killer (NK) cell–based cancer immunotherapy by overcoming immunosuppression is an area of intensive research. Here, we have demonstrated that the anti-CD137 agonist urelumab can overcome TGFβ-mediated inhibition human NK-cell proliferation and antitumor function. Transcriptomic, immunophenotypic, functional analyses showed CD137 costimulation modified transcriptional program induced TGFβ on NK cells rescuing their in response to IL2, preserving expression...
MYC translocation is a defining feature of Burkitt lymphoma (BL), and the new category high-grade B-cell lymphomas with BCL2 and/or BCL6 translocations, occurs in 6% to 15% diffuse large (DLBCLs). The low incidence translocations DLBCL makes genetic study all these cumbersome. Strategies based on an initial immunophenotypic screening select cases high probability carrying may be useful. LMO2 germinal center marker expressed most originated cells. Mining gene expression profiling studies, we...
We aimed to assess differences in breast cancer risk across benign disease diagnosed at prevalent or incident screens.We conducted a retrospective cohort study with data from 629,087 women participating long-standing population-based screening program Spain. Each was classified as non-proliferative, proliferative without atypia, and whether it screen. used partly conditional Cox hazard regression estimate the adjusted ratios of cancer.Compared disease, significantly higher (p-value = 0.005)...