A5003491099- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Sepsis Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Immune Response and Inflammation
- Long-Term Effects of COVID-19
- Cell Adhesion Molecules Research
- Antibiotic Resistance in Bacteria
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Lung Cancer Research Studies
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Bipolar Disorder and Treatment
- Vaccine Coverage and Hesitancy
- Tuberculosis Research and Epidemiology
- Cancer Treatment and Pharmacology
- Biliary and Gastrointestinal Fistulas
- Inflammatory Biomarkers in Disease Prognosis
- Traditional Chinese Medicine Analysis
Hospital Universitario La Paz
2020-2025
Hospital La Paz Institute for Health Research
2021-2023
Universidad de Zaragoza
2023
Hospital Del Mar
2021
Hospital del Mar Research Institute
2021
Centro de Investigación Biomédica en Red de Cáncer
2021
Centro Nacional de Biotecnología
2020
Weatherford College
2020
Innate Pharma (France)
2020
Servicio Aragonés de Salud
2015
Sepsis is associated with T-cell exhaustion, which significantly reduces patient outcomes. Therefore, targeting of immune checkpoints (ICs) deemed necessary for effective sepsis management. Here, we evaluated the role SIGLEC5 as an IC ligand and explored its potential a biomarker sepsis.In vitro in vivo assays were conducted to both analyse SIGLEC5's ligand, well assess impact on survival sepsis. A multicentre prospective cohort study was evaluate plasmatic soluble (sSIGLEC5) mortality...
We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) later (almost 8 months) vaccination. Plasma spike (S)-specific immunoglobulins peak one vaccine shot COVID-19, while a second dose is needed subjects, although the latter group shows reduced levels all along period. Despite how neutralization capacity against severe acute respiratory syndrome 2 (SARS-CoV-2) mirrors this...
Background SARS-CoV-2, the causative virus of COVID-19 global pandemic, leads to a wide variety responses among patients. Some them present very severe phenotype, while others only experience mild symptoms or are even asymptomatic. This differential prognosis is tightly related inflammatory status patient. Although WHO declared end emergency, pandemic caused great socio-sanitary impact in all countries. Thus, possible outbreak new biological diseases future makes it necessary deepen...
We compared the prevalence rates of peptic ulcer (duodenal and gastric) gastric cancer in 1,796 dyspeptic Peruvian patients with those reported 2,883 similar from developed countries. The total was significantly lower, that higher, patients. lower but not so. deduced directly related to low rate duodenal ulcer. hypothesize reason for these differences probably a higher Helicobacter pylori-associated chronic atrophic gastritis hypochlorhydria Hypochlorhydria decreases predisposition...
The 'cancer cell fusion' theory is controversial due to the lack of methods available identify hybrid cells and follow phenomenon in patients. However, it seems be one best explanations for both origin metastasis primary tumors. Herein, we co-cultured lung cancer stem with human monocytes analyzed dynamics properties tumor-hybrid (THC), as well molecular mechanisms beneath this fusion process by several techniques: electron-microscopy, karyotyping, CRISPR-Cas9, RNA-seq, immunostaining,...
Abstract Enhancing natural killer (NK) cell–based cancer immunotherapy by overcoming immunosuppression is an area of intensive research. Here, we have demonstrated that the anti-CD137 agonist urelumab can overcome TGFβ-mediated inhibition human NK-cell proliferation and antitumor function. Transcriptomic, immunophenotypic, functional analyses showed CD137 costimulation modified transcriptional program induced TGFβ on NK cells rescuing their in response to IL2, preserving expression...
The cancer cell fusion theory could be one of the best explanations for metastasis from primary tumours.
Sepsis is a pathology in which patients suffer from proinflammatory response and dysregulated immune response, including T cell exhaustion. A number of therapeutic strategies to treat human sepsis, are different antimicrobial fluid resuscitation treatments, have failed clinical trials, solid biomarkers for sepsis still lacking. Herein, we classified 85 with into two groups according their blood oxygen saturation (SaO2): group I (SaO2 ≤92%, n=42) II >92%, n=43). Blood samples were taken...
We report the disparate clinical progression of a couple infected by SARS-CoV-2 based on their immune checkpoint (IC) levels and cell distribution in blood from admission to exitus patient 1 discharge recovery 2. A detailed follow-up accompanied longitudinal analysis phenotypes IC is shown. The continuous increase soluble ligand galectin-9 (Gal-9) increment T-cell immunoglobulin mucin domain-containing 3 (TIM-3) protein T cells suggests an activation Gal-9/TIM-3 axis and, subsequently,...
Bladder cancer (BC) is the second most frequent of genitourinary system. The successful therapy since 1970s has consisted intravesical instillations Bacillus Calmette–Guérin (BCG) in which tumor microenvironment (TME), including macrophages, plays an important role. However, some patients cannot be treated with this due to comorbidities and severe inflammatory side effects. overexpression histone deacetylases (HDACs) BC been correlated macrophage polarization together higher grades poor...
Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we reported a monocyte polarization towards low HLA-DR high PD-L1 after long exposure to proteins from SARS-CoV-2. Moreover, CD86 was also reduced over SARS-CoV-2 exposure. Additionally, T-cells proliferation significantly stimulation these proteins. Eventually, long-term infection exhibited significant blockade of proliferation.
Abstract Despite viral control, basal chronic inflammation and its related comorbidities remain unsolved problems among HIV-infected individuals. Soluble factors derived from myeloid cells have emerged as potent markers associated with HIV-related mortality. In the present report, we explored relationship between soluble programmed death-ligand 1 (sPD-L1) HIV-1 infection, antiretroviral therapy (ART), CD4/CD8 ratio, load (VL), sexually transmitted coinfections. A prospective observational...
Colorectal cancer (CRC) is the second most deadly and third commonly diagnosed worldwide. There significant heterogeneity among patients with CRC, which hinders search for a standard approach detection of this disease. Therefore, identification robust prognostic markers CRC represents an urgent clinical need. In such biomarkers, total 114 colorectal 67 healthy participants were studied. Soluble SIGLEC5 (sSIGLEC5) levels higher in plasma from compared volunteers. Additionally, sSIGLEC5 exitus...
Colistin resistance is acquired by different lipopolysaccharide (LPS) modifications. We proposed to evaluate the of effect in vivo colistin acquisition on innate immune response. used a pair ST11 clone Klebsiella pneumoniae strains: an OXA-48, CTX-M-15 K. strain susceptible (CS-Kp) isolated from urinary infection and its colistin-resistant variant (CR-Kp) same patient after prolonged treatment with colistin. No mutation previously described genes for (pmrA, pmrB, mgrB, phoP/Q, arnA, arnC,...
Garlic (Allium sativum) has historically been associated with antioxidant, immunomodulatory, and microbiocidal properties, mainly due to its richness in thiosulfates sulfur-containing phytoconstituents. Sepsis patients could benefit from these properties because it involves both inflammatory refractory processes. We evaluated the effects of thiosulfinate-enriched Allium sativum extract (TASE) on immune response bacterial lipopolysaccharide (LPS) by monocytes healthy volunteers (HVs) sepsis....
Introduction COVID-19 vaccines based on mRNA have represented a revolution in the biomedical research field. The initial two-dose vaccination schedule generates potent humoral and cellular responses, with massive protective effect against severe death. Months after this vaccination, levels of antibodies SARS-CoV-2 waned, promoted recommendation third dose. Methods We performed an integral longitudinal study immunological responses triggered by booster mRNA-1273 cohort health workers...
Lung cancer (LC) continues to be the leading cause of cancer-related deaths in both men and women worldwide. After complete tumour resection, around half patients suffer from disease relapse, emphasising critical need for robust relapse predictors this disease. In search such biomarkers, 83 with non-microcytic lung 67 healthy volunteers were studied. Pre-operative levels sSIGLEC5 along other soluble immune-checkpoints measured correlated their clinical outcome. Soluble SIGLEC5 (sSIGLEC5)...
Objective: This study aimed to evaluate the influence of cigarette smoking habit on clozapine (CLZ)-to-norclozapine (norCLZ) ratio in male patients. Methods: The sample consisted plasma concentration CLZ and norCLZ data set. mean values CLZ, norCLZ, CLZ-to-norCLZ, between patients who smoke versus nonsmokers were compared. Findings: level 142 ± 80 ng/ml 305 159 ng/ml, 93 72 234 62 CLZ-to-norCLZ 2.1 1.1 1.5 0.5, obtained respectively for nonsmokers. Conclusion: has shown a significant...
The association of specific genetic disturbances with the development hereditary cancer helps us to understand risk suffering from it, possibility an earlier diagnosis, and treatment prevention this disease.Familial adenomatous polyposis (FAP) is a pre-neoplastic syndrome characterized by presence hundreds polyps in colon, which develop into carcinoma.FAP can be diagnosed using sequencing techniques detect mutations germinal line APC (adenomatous coli) gene.The diagnostic approach families...
ABSTRACT Sepsis is a global health priority. Despite thorough studies in mice models, its molecular and cellular basis remain unclear there no pharmacological effective treatment other than antimicrobial supportive therapy. During sepsis, T cells exhaustion compromises patients’ outcome, immune checkpoints (ICs) become crucial players disease management. Here, total of 425 patients with systemic inflammatory response criteria 127 controls were studied. Soluble SIGLEC5 (sSIGLEC5) levels...