A5061223866- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Galectins and Cancer Biology
- Reproductive System and Pregnancy
- HIV Research and Treatment
- COVID-19 and healthcare impacts
- Pancreatitis Pathology and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Cancer Immunotherapy and Biomarkers
Hospital Universitario La Paz
2021-2024
We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) later (almost 8 months) vaccination. Plasma spike (S)-specific immunoglobulins peak one vaccine shot COVID-19, while a second dose is needed subjects, although the latter group shows reduced levels all along period. Despite how neutralization capacity against severe acute respiratory syndrome 2 (SARS-CoV-2) mirrors this...
Organ transplantation is a lifesaving procedure, with 50,000 transplants happening every year in the United States. However, many patients harbor antibodies and B cells directed against allogeneic human leukocyte antigen (HLA) molecules, notably HLA-A2, greatly decreasing their likelihood of receiving compatible organ. Moreover, antibody-mediated rejection significant contributor to chronic transplant rejection. Current strategies desensitize non-specifically target circulating cells,...
Abstract Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) that control replication without therapy. Among the mechanisms involved in this ability, natural killer (NK)‐cells have recently gained much attention. We performed in‐deep phenotypic analysis NK‐cells to search for surrogate markers associated long term spontaneous HIV. Forty‐seven PLWH (22 long‐term EC [PLWH‐long‐term elite (LTECs)], 15 noncontrollers receiving antiretroviral treatment [ART]...
Elite controllers (ECs) are people living with HIV (PLWH) able to control replication without antiretroviral therapy and have been proposed as a model of functional cure. Much evidence suggests that this spontaneous has cost in terms T cell homeostasis alterations. We performed deep phenotypic study obtain insight into disturbances ECs maintaining long-term virologic immunologic (long-term elite controllers; LTECs). Forty-seven PLWH were included: 22 LTECs, 15 non-controllers under...
Human-adipose-derived mesenchymal stem cells (hADMSCs) are multipotent which have become of great interest in stem-cell therapy due to their less invasive isolation. However, they limited migration and short lifespans. Therefore, understanding the mechanisms by these could migrate is critical importance for regenerative medicine. Methods: Looking novel alternatives, herein, hADMSCs were isolated from adipose tissue co-cultured with human monocytes ex vivo. Results: A new fused hybrid entity,...
Medical history of COVID-19 was an exclusion criterion in the clinical trial that led to vaccination regimen two-doses for BNT162b2 SARS-CoV-2 mRNA vaccine. Herein, we have analyzed a wide panel immune responses triggered by this immunization cohort naïve and COVID-19-recovered individuals. Plasma levels S-specific immunoglobulins peaked after one vaccine shot individuals, while second dose needed subjects achieve similar levels. However, individuals did not reach as much neutralizing titers...