Alejandro Zarauza-Santovena

ORCID: 0000-0002-9415-8911
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About
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Research Areas
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • T-cell and B-cell Immunology

Organ transplantation is a lifesaving procedure, with 50,000 transplants happening every year in the United States. However, many patients harbor antibodies and B cells directed against allogeneic human leukocyte antigen (HLA) molecules, notably HLA-A2, greatly decreasing their likelihood of receiving compatible organ. Moreover, antibody-mediated rejection significant contributor to chronic transplant rejection. Current strategies desensitize non- specifically target circulating cells,...

10.1101/2025.03.27.645777 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2025-04-01
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