A5048558239- Cancer Risks and Factors
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- Crystallization and Solubility Studies
- Cancer Genomics and Diagnostics
- X-ray Diffraction in Crystallography
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Lung Cancer Treatments and Mutations
- Nanopore and Nanochannel Transport Studies
- Fractional Differential Equations Solutions
- Immune Cell Function and Interaction
- Mathematical functions and polynomials
- Covalent Organic Framework Applications
- Lung Cancer Research Studies
- Industrial Vision Systems and Defect Detection
- Nonlinear Waves and Solitons
- HER2/EGFR in Cancer Research
- Metabolism, Diabetes, and Cancer
- Brain Metastases and Treatment
- Diet, Metabolism, and Disease
- Iterative Methods for Nonlinear Equations
- Neuroinflammation and Neurodegeneration Mechanisms
National Chung Hsing University
2020-2025
Taichung Veterans General Hospital
2017-2025
National Yang Ming Chiao Tung University
2004-2025
King Abdullah University of Science and Technology
2021-2024
National Tsing Hua University
2024
Kaohsiung Chang Gung Memorial Hospital
2017-2024
National Taiwan University
2012-2024
Far Eastern Memorial Hospital
2024
Providence Health & Services
2023-2024
National Taiwan University Hospital
2015-2024
Abstract Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the research communities. We evaluated sources of variability sTIL assessment pathologists three previous ring studies. identify common challenges evaluate impact...
Nanofluidic membranes have been demonstrated as promising candidates for osmotic energy harvesting. However, it remains a long-standing challenge to fabricate high-efficiency ion-permselective with well-defined channel architectures. Here, we demonstrate high-performance conversion based on oriented two-dimensional covalent organic frameworks (COFs) ultrashort vertically aligned nanofluidic channels that enabled efficient and selective ion transport. Experiments combined molecular dynamics...
Printed circuit boards (PCBs) are primarily used to connect electronic components each other. It is one of the most important stages in manufacturing products. A small defect PCB can make final product inoperable. Therefore, careful and meticulous detection steps necessary indispensable process. The methods generally be divided into manual inspection automatic optical (AOI). main disadvantage that speed too slow, resulting a waste human resources costs. Thus, order up production speed, AOI...
Trimethylamine N-oxide (TMAO) is a metabolite originated from bacterial metabolism of choline-rich foods. Evidence suggests an association between TMAO and atherosclerosis, but the relationship endothelial progenitor cells (EPCs) remains unclear. This study aimed to identify concentrations, circulating EPCs, function in patients with stable angina. Eighty-one angina subjects who underwent coronary angiography were enrolled. The EPCs flow-mediated vasodilation (FMD) measured evaluate...
Nanofluidic ion transport holds high promise in bio-sensing and energy conversion applications. However, smart nanofluidic devices with flux modulable capabilities remain to be realised. Herein, we demonstrate based on oriented two-dimensional covalent organic framework (2D COF) membranes vertically aligned nanochannel arrays that achieved a 2-3 orders of magnitude higher compared conventional single-channel devices. The surface-charge-governed conductance is dominant for electrolyte...
Heterogeneous membranes that exhibit an ionic diode effect are promising candidates for osmotic energy conversion. However, existing heterogeneous lack molecular-level designed ion channels, thereby limiting their power densities. Here, we demonstrate covalent organic framework (COF) with well-defined asymmetric geometry and surface charge polarity as high-performance generators. The COF comprised of heterojunctions combining a positively charged ultrathin layer negatively supported by...
Abstract Biological cell membranes can efficiently switch Na + /K selectivity in response to external stimuli, but achieving analogous functions a single artificial membrane is challenging. Here, we report highly crystalline covalent organic framework (COF) with well-defined nanochannels and coordinative sites (i. e., amino acid) that act as ion-selective switches manipulate K transport. The ion of the COF dynamic be switched between -selective by applying pH stimulus. experimental results...
Abstract Background The clinicopathological features and prognosis of breast cancer in Asia are different from those the Western countries. Tumor-infiltrating immune cells can influence outcome patients with cancer, but they have not been systemically evaluated Asian cancer. Methods We compared score, composition, prognostic impact infiltrating between by analyzing gene expression profiles eight Gene Expression Omnibus data sets Cancer Genome Atlas set. Estimation Stromal Immune Cells...
Signaling driven by nucleic acid sensors participates in interferonopathy-mediated autoimmune diseases. NLRP12, a pyrin-containing NLR protein, is negative regulator of innate immune activation and type I interferon (IFN-I) production. Peripheral blood mononuclear cells (PBMCs) derived from systemic lupus erythematosus (SLE) patients expressed lower levels with an inverse correlation IFNA expression high disease activity. NLRP12 was transcriptionally suppressed runt-related transcription...
α-synuclein (SNCA) accumulation in the substantia nigra is one of characteristic pathologies Parkinson's disease (PD). A53T missense mutations SNCA gene has been proved to enhance expression and accelerate onset PD. Mitochondrial dysfunction aggregation under debate for decades but causal relationship remains uncertain. At a later stage PD, cellular dysfunctions are complicated multiple factors tangled. Our aim here investigate mitochondrial functional changes clarify main mechanism at earlier-stage
Abstract Obesity is associated with increased cancer risk and weak responses to vaccination sepsis treatment. Although dendritic cells (DCs) are fundamental for the initiation maintenance of competent immune against pathogens tumors, how obesity alters normal physiology these myeloid remains largely unexplored. In this study, we report that caused by prolonged high-fat diet feeding disrupts metabolic functional status mouse splenic DCs (SpDCs). High-fat diet–induced drastically altered...
Lidocaine, a local anesthetic, has been shown to modulate immune responses. This study examines its effects on cytokine production in peripheral blood mononuclear cells (PBMCs) from healthy donors and tumor-infiltrating (TIICs) gastric cancer patients. PBMCs TIICs patients were treated with lidocaine. Cytokine was assessed using flow cytometry assays, focus IFN-γ, IL-12, IL-10, TGF-β, IL-35 levels. Cytotoxicity against primary (PGCCs) also evaluated. Lidocaine inhibited...
Lidocaine, a local anesthetic, has been shown to modulate immune responses. This study examines its effects on cytokine production in peripheral blood mononuclear cells (PBMCs) from healthy donors and tumor-infiltrating (TIICs) gastric cancer patients. PBMCs TIICs patients were treated with lidocaine. Cytokine was assessed using flow cytometry assays, focus IFN-γ, IL-12, IL-10, TGF-β, IL-35 levels. Cytotoxicity against primary (PGCCs) also evaluated. Lidocaine inhibited IFN-γ CD8+ IL-12...
Abstract Background: Metaplastic carcinoma of breast (MCB) is a rare subtype cancer (BC) accounting for <1% newly diagnosed BC. It composed co-existing sarcomatous and carcinomatous components. Because its components, the response rate chemotherapy in MCB low both early BC advanced The pathologic complete (pCR%) after neoadjuvant as 10%. Neoadjuvant immunotherapy plus new standard care triple-negative providing improved pCR%, event-free survival, overall survival. Pembrolizumab was...
This study was undertaken to assay the effect of lovastatin on glycogen synthase kinase-3 beta (GSK-3β) and collapsin responsive mediator protein-2 (CRMP-2) signaling pathway mossy fiber sprouting (MFS) in epileptic rats. MFS dentate gyrus (DG) is an important feature temporal lobe epilepsy (TLE) highly related severity frequency spontaneous recurrent seizures. However, molecular mechanism mostly unknown. GSK-3β CRMP-2 are genes responsible for axonal growth neuronal polarity hippocampus,...
Obesity is associated with white adipose tissue (WAT) inflammation in the breast, elevated levels of estrogen biosynthetic enzyme, aromatase, and systemic changes that predispose to breast cancer development. We examined whether WAT its effects correlate body fat an Asian population where mass index (BMI) not accurate assessment obesity risk. also investigated biologic differences could account for greater proportion premenopausal receptor (ER)-positive versus Western countries. Breast...