A5074569988- Diet and metabolism studies
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
- Genetic factors in colorectal cancer
- Vitamin D Research Studies
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Microscopic Colitis
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Clinical Nutrition and Gastroenterology
- Gastroesophageal reflux and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related Molecular Pathways
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Celiac Disease Research and Management
- Pancreatic and Hepatic Oncology Research
- Probiotics and Fermented Foods
Rockefeller University
2014-2023
Pediatrics and Genetics
2016
St. Luke's-Roosevelt Hospital Center
1999-2015
Mount Sinai Beth Israel
2012
National Cancer Institute
2000-2011
UConn Health
2009-2011
Roswell Park Comprehensive Cancer Center
2011
VA Connecticut Healthcare System
2011
Tufts University
2011
Cornell University
2002-2011
Helicobacter pylori may promote gastric carcinogenesis through increasing epithelial cell proliferation. How H does so is unknown. Programmed, non-necrotic, death (apoptosis) occurs throughout the gut and linked to It was hypothesised that induce hyper-proliferation apoptosis.To measure effect of infection on apoptosis in situ.Patients with duodenal ulcers treated eradicate patients negative non-ulcer dyspepsia.Retrospective quantification apoptotic cells situ from formalin fixed biopsy...
Background: Infection with Helicobacter pylori induces chronic gastritis in virtually all infected persons, and such has been associated an increased risk of developing gastric cancer. This is further enhanced cagA + (positive for cytotoxin-associated gene A) H. strains may be a consequence induced cell proliferation and/or alteration apoptosis (programmed death) the epithelium. Purpose: To determine whether genotype another virulence-related characteristic, vacA (vacuolating cytotoxin s1a...
Objective To compare the clinical efficacy of rofecoxib, a specific inhibitor cyclooxygenase 2 (COX-2), with that diclofenac in patients osteoarthritis (OA) and to evaluate safety tolerability rofecoxib. Methods We performed randomized, double-blind, active comparator–controlled trial 784 adults OA knee or hip. Patients were randomized 1 3 treatment groups: 12.5 mg rofecoxib once daily, 25 50 times daily. Clinical evaluated over 1-year continuous period. Results Rofecoxib at dosages...
Studies of taurocholate and cholate-C 14 absorption by slices rat intestine reveal that an active absorptive mechanism obeying Michaelis-Menten kinetics is present in the ileum but absent other portions gut. Following 1 day bile duct cannulation, vitro salts was enhanced two- to three-fold. The normal tissue concentration reached 1.3 µm jejunum 0.35 µm/g water. presence endogenous resulted inhibition subsequent ileal competitively suggesting existence a common receptor site for mucosal salt...
Microbiota and bile acids in the gastrointestinal tract profoundly alter systemic metabolic processes. In obese subjects, gradual weight loss ameliorates adipose tissue inflammation related changes. We assessed how rapid due to a very low calorie diet (VLCD) affects fecal microbiome acid composition, their interactions with plasma metabolome subcutaneous obesity.We performed prospective cohort study of VLCD-induced 10% ten grades 2-3 postmenopausal women unit. Baseline post evaluation...
Obesity is characterized by chronic systemic inflammation and enhances cancer metastasis mortality. promotes breast to lung in a neutrophil-dependent manner; however, the upstream regulatory mechanisms of this process remain unknown. Here, we show that obesity-induced monocytes underlie neutrophil activation metastasis. Using mass cytometry, obesity favors expansion myeloid lineages while restricting lymphoid cells within peripheral blood. RNA sequencing flow cytometry revealed...
BACKGROUND: Coeliac disease (CD) mucosa is flattened despite epithelial hyperproliferation. AIMS: To establish mechanisms of cell loss in CD. PATIENTS: 14 controls, 17 active CD patients, and 16 maintained with gluten free diet. METHODS: Programmed death was examined small intestinal biopsy specimens by staining fragmented DNA using terminal uridine deoxynucleotidyl nick end labelling (TUNEL), comparison haematoxylin eosin stained adjacent sections. Double anti-CD45 antibodies determined the...
Context.—Before the development of human colonic neoplasms, epithelial cells showed altered growth and differentiation. These alterations characterized mucosa at risk for cancer formation were termed intermediate biomarkers risk. Modifications toward more normal features by nutrients or drugs are putative approaches to chemoprevention colon cancer.Objective.—To determine whether increasing calcium intake via dairy products alters normal.Design.—Randomized, single-blind, controlled...
Altered expression of lamins A/C and B1, constituent proteins the nuclear lamina, may occur during differentiation has also been reported in primary lung cancer.To examine these gastrointestinal neoplasms.Archival human paraffin wax blocks frozen tissue from patients undergoing surgical resection or endoscopic biopsy.Immunohistochemistry western blotting using polyclonal antisera against A type lamin B1.The was reduced frequently undetectable by immunohistochemistry all colon carcinomas...