A5086788282- Immune cells in cancer
- Immune responses and vaccinations
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Gestational Diabetes Research and Management
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- COVID-19 Impact on Reproduction
- Cancer, Stress, Anesthesia, and Immune Response
- Dietary Effects on Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Lymphoma Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Phagocytosis and Immune Regulation
- Adipokines, Inflammation, and Metabolic Diseases
McGill University Health Centre
2023-2025
McGill University
2023-2025
Queen's University
2021-2024
Obesity is characterized by chronic systemic inflammation and enhances cancer metastasis mortality. promotes breast to lung in a neutrophil-dependent manner; however, the upstream regulatory mechanisms of this process remain unknown. Here, we show that obesity-induced monocytes underlie neutrophil activation metastasis. Using mass cytometry, obesity favors expansion myeloid lineages while restricting lymphoid cells within peripheral blood. RNA sequencing flow cytometry revealed...
Treatment for higher-risk non-muscle invasive bladder cancer (NMIBC) involves intravesical immunotherapy with Bacillus Calmette Guérin (BCG); however, disease recurrence and progression occur frequently. Systemic immunity is critical successful immunotherapy; thus, of NMIBC may be due to suboptimal systemic activation anti-tumor after local immunotherapy. We previously reported that systemically acquired trained (a form innate immune memory) in circulating monocytes associated increased...
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e15169 Background: PDX and PDO are two of the most frequently applied avatar model systems used to predict treatment response anti-cancer therapies. Despite their frequent use, significant financial ethical costs associated with developing these models, there has never been a systematic assessment ability matched-patient response. We sought define compare efficacy in predicting treatment. Methods: performed review meta-analysis accordance PRISMA guidelines. MEDLINE EMBASE were queried....
Abstract Children of women with pre-eclampsia have increased risk cardiovascular (CV) and metabolic disease in adult life. Furthermore, the pregnancy complications is higher daughters born to affected by than after uncomplicated pregnancies. While aberrant inflammation contributes pathophysiology complications, including pre-eclampsia, contribution maternal subsequent CV as well offspring remains unclear. Here, we demonstrate that 24-week-old female rats (F1) dams (F0) exposed...
BACKGROUND: The mode of action Bacillus Calmette-Guérin (BCG) in the treatment patients with non-muscle invasive bladder cancer (NMIBC) is incompletely understood, but recent studies support an association between BCG-induced trained immunity circulating monocytes and disease-free survival. OBJECTIVE: We compared epigenetic profiles from NMIBC early disease recurrence those recurrence-free patients. METHODS: conducted chromatin immunoprecipitation DNA sequencing (ChIP-seq) on seven treated...
Abstract Background: Bladder cancer is the 5th most common worldwide, with type being non-muscle invasive bladder (NMIBC). Treatment for high grade NMIBC includes resection of tumor followed by repeated intravesical administration Bacillus-Calmette Guérin (BCG), live-attenuated form Mycobacterium bovis. Unfortunately, 60-70% patients will experience disease recurrence. Our current understanding that BCG acts within local microenvironment and draining lymph nodes, leading to activation a...
Single-cell technologies have revealed novel insights about the complexity of tumor immune microenvironment. Most clinical strategies rely on histopathological stratification subtypes, yet spatial context cellular interactions within these stratified subgroups remains poorly understood. We previously applied imaging mass cytometry, a technology, to describe and immunological landscape lung adenocarcinoma (LUAD) patient tumors across five histological subtypes adenocarcinoma. resolved over 1...
Glioblastomas are grade IV gliomas of the central nervous system associated with a median survival rate less than 15 months. Therefore, research has been focused on better understanding role tumor immune microenvironment, specifically macrophages (tissue-resident and monocyte-derived), which make up to 30% tumour. Using imaging mass cytometry, we have demonstrated that long-term in glioblastoma is an accumulation rare subset MPO+ monocyte-derived (MDM) within tumors, appeared originate from...
Abstract Background: Bladder cancer is the fifth most common in North America, with up to 80% of cases being non-muscle invasive bladder (NMIBC). The standard care for high-risk NMIBC involves intravesical immunotherapy Bacillus Calmette Guérin (BCG), a live attenuated bacterium. Unfortunately, patients do not respond fully this therapy, resulting recurrences that sometimes progress disease. Moreover, our understanding how BCG exerts its immunotherapeutic effect incomplete. Using mouse model...
Abstract Background: Bladder cancer is the fifth most common in North America. The standard of care for high-risk non-muscle invasive bladder (NMIBC) involves intravesical immunotherapy with Bacillus Calmette Guérin (BCG). However, it possible that efficacy this modality BCG administration suboptimal, as patients do not respond fully to immunotherapy. Furthermore, our current understanding immunotherapeutic effect incomplete. Using a mouse model NMIBC, we compared tumor immune...
Abstract Children of women with pre-eclampsia have increased risk cardiovascular (CV) and metabolic disease in adult life. Furthermore, the pregnancy complications is higher daughters born to affected by than after uncomplicated pregnancies. While aberrant inflammation contributes pathophysiology complications, including pre-eclampsia, contribution maternal subsequent CV as well offspring remains unclear. Here we demonstrate that 24-week-old female rats (F1) dams (F0) exposed...