A5017251462- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Genomics and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Marxism and Critical Theory
- Political Theory and Influence
- Glioma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Seventeenth-Century Political and Philosophical Thought
McGill University
2023-2025
McGill University Health Centre
2021-2025
Abstract Single-cell technologies have enabled the characterization of tumour microenvironment at unprecedented depth and revealed vast cellular diversity among cells their niche. Anti-tumour immunity relies on cell–cell relationships within 1,2 , yet many single-cell studies lack spatial context rely dissociated tissues 3 . Here we applied imaging mass cytometry to characterize immunological landscape 139 high-grade glioma 46 brain metastasis tumours from patients. analysis more than 1.1...
Abstract Single-cell technologies have revealed the complexity of tumour immune microenvironment with unparalleled resolution 1–9 . Most clinical strategies rely on histopathological stratification subtypes, yet spatial context single-cell phenotypes within these stratified subgroups is poorly understood. Here we apply imaging mass cytometry to characterize and immunological landscape samples from 416 patients lung adenocarcinoma across five histological patterns. We resolve more than 1.6...
Immunotherapy has revolutionized clinical outcomes for patients suffering from lung cancer, yet relatively few sustain long-term durable responses. Recent studies have demonstrated that the tumor immune microenvironment fosters tumorous heterogeneity and mediates both disease progression response to checkpoint inhibitors (ICI). As such, there is an unmet need elucidate spatially defined single-cell landscape of cancer understand mechanisms identify biomarkers ICI.Here, in this study, we...
Obesity is characterized by chronic systemic inflammation and enhances cancer metastasis mortality. promotes breast to lung in a neutrophil-dependent manner; however, the upstream regulatory mechanisms of this process remain unknown. Here, we show that obesity-induced monocytes underlie neutrophil activation metastasis. Using mass cytometry, obesity favors expansion myeloid lineages while restricting lymphoid cells within peripheral blood. RNA sequencing flow cytometry revealed...
Abstract Somatic copy number alterations (SCNAs) are prevalent in cancer and play a significant role both tumorigenesis therapeutic resistance. While focal SCNAs have been extensively studied, the impact of larger arm-level remains poorly understood. Here, we investigated association between overall survival triple-negative breast (TNBC), an aggressive subtype lacking targeted therapies. We identified frequent SCNAs, including 21q gain 7p gain, which correlated with poor TNBC patients....