A5102810582- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Asthma and respiratory diseases
- Chemokine receptors and signaling
McGill University
2023
Obesity is characterized by chronic systemic inflammation and enhances cancer metastasis mortality. promotes breast to lung in a neutrophil-dependent manner; however, the upstream regulatory mechanisms of this process remain unknown. Here, we show that obesity-induced monocytes underlie neutrophil activation metastasis. Using mass cytometry, obesity favors expansion myeloid lineages while restricting lymphoid cells within peripheral blood. RNA sequencing flow cytometry revealed...
Neutrophils are the first responders of innate immune system and have been implicated in lung cancer progression metastasis to secondary organs. Neutrophil trafficking effector functions temporally controlled by chemokine receptor CXCR2 circadian rhythm. Due their diurnal regulation, it remains elusive whether neutrophils can be effectively targeted cancer. To study role tumor-derived ligands neutrophil chemoattraction vitro, we designed a migration assay using microfluidic chips. We...