A5047504179- Diagnosis and treatment of tuberculosis
- Immune cells in cancer
- Diverticular Disease and Complications
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Sarcoidosis and Beryllium Toxicity Research
- Adipokines, Inflammation, and Metabolic Diseases
- Congenital Anomalies and Fetal Surgery
- Appendicitis Diagnosis and Management
- Inflammatory Biomarkers in Disease Prognosis
- Infectious Diseases and Tuberculosis
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Bone fractures and treatments
- Economic theories and models
- Birth, Development, and Health
- IL-33, ST2, and ILC Pathways
- Endometriosis Research and Treatment
- Cancer, Lipids, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Obesity and Health Practices
- RNA Research and Splicing
- Dietary Effects on Health
- Arctic and Antarctic ice dynamics
- Cancer, Stress, Anesthesia, and Immune Response
McGill University
2023
Hôpital de la Conception
2010-2011
Obesity is characterized by chronic systemic inflammation and enhances cancer metastasis mortality. promotes breast to lung in a neutrophil-dependent manner; however, the upstream regulatory mechanisms of this process remain unknown. Here, we show that obesity-induced monocytes underlie neutrophil activation metastasis. Using mass cytometry, obesity favors expansion myeloid lineages while restricting lymphoid cells within peripheral blood. RNA sequencing flow cytometry revealed...
Obesity is associated with chronic inflammation and elevated incidence mortality from multiple cancer types, including colorectal (CRC). We found that CRC progression enhanced in diet induced obesity (DIO) mouse models. Obesity-induced metastasis showed significant enrichment myeloid cells coinciding a relative decrease lymphoid populations. However, the functional contribution of these associations to remains unknown. Here we define how changes tumor immune microenvironment (TIME) alter...