A5038766995- Acute Myocardial Infarction Research
- Sepsis Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Galectins and Cancer Biology
- Nutrition and Health in Aging
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Cardiovascular Disease and Adiposity
- Hemodynamic Monitoring and Therapy
- Pancreatitis Pathology and Treatment
- Fibroblast Growth Factor Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Lipoproteins and Cardiovascular Health
- Cardiac Arrhythmias and Treatments
- TGF-β signaling in diseases
- Intensive Care Unit Cognitive Disorders
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Vitamin D Research Studies
National Yang Ming Chiao Tung University
2015-2024
Taipei Veterans General Hospital
2015-2024
Cardiovascular Research Center
2019-2024
Taipei Medical University
2019-2023
National Yang Ming University Hospital
2017-2020
National Academy of Medicine
2019
Institute of Clinical Research
2019
Institute of Pharmacology
2019
Taipei Institute of Pathology
2016
Trimethylamine N-oxide (TMAO) is a metabolite originated from bacterial metabolism of choline-rich foods. Evidence suggests an association between TMAO and atherosclerosis, but the relationship endothelial progenitor cells (EPCs) remains unclear. This study aimed to identify concentrations, circulating EPCs, function in patients with stable angina. Eighty-one angina subjects who underwent coronary angiography were enrolled. The EPCs flow-mediated vasodilation (FMD) measured evaluate...
Abstract Background Insulin resistance (IR) is a known risk factor for cardiovascular disease (CVD) in non-diabetic patients through the association of hyperglycemia or associated metabolic factors. The triglyceride glucose (TyG) index, which was defined by incorporating serum and insulin concentrations, developed as surrogate marker resistance. We aimed to investigate between TyG index early phase subclinical atherosclerosis (SA) sexes. Methods I-Lan Longitudinal Aging Study (ILAS) enrolled...
Abstract Serum uric acid level is a risk factor for cardiovascular disease (CVD). However, whether it an independent or not remains controversial. We analyzed the association between serum and risk. In total, 973 nonhypertensive nondiabetic participants in I-Lan Longitudinal Aging Study were eligible this study. Subjects divided into tertiles according to levels. The 10-year was calculated using Framingham score (FRS). subjects highest tertile of older, more likely be male, had higher...
Abstract Fibroblast growth factor 21 (FGF21), a polypeptide ligand promoted glucose homeostasis and lipids metabolism, was recently reported to attenuate cardiac hypertrophy. The aim of this study investigate the impact FGF21 in diastolic heart failure. Subjects admitted for coronary angiogram were screened failure those with left ventricular (LV) ejection fraction < 45% excluded. Diastolic dysfunction defined as functional abnormalities that exist during LV relaxation filling by...
Backgrounds Lower health literacy (HL) is associated with several cardiovascular disease (CVD) risk factors such as diabetes, hypertension, and metabolic syndrome (MS). The aim of our study was to investigate the association between HL Framingham 10-year score CVD. Methods From 2015–2016, 1010 subjects aged 23 88 years receiving check-up in Taipei Veterans General Hospital had complete clinical evaluations laboratory examinations. Fatty liver diagnosed by ultrasonography. short form...
Aims: Trimethylamine-N-oxide (TMAO) is a metabolite generated from dietary choline, betaine, and l-carnitine, after their oxidization in the liver. TMAO has been identified as novel independent risk factor for atherosclerosis through induction of vascular inflammation. However, effect on neointimal formation response to injury remains unclear. Results: This study was conducted using murine model acutely disturbed flow-induced induced by partial carotid artery ligation. 3,3-Dimethyl-1-butanol...
Background Coronary artery disease (CAD) is one of the leading causes morbidity and mortality in patients with type 2 diabetes mellitus (T2DM), who are at a greater risk acute myocardial infarction (AMI) sudden cardiac death. Sodium-glucose cotransporter (SGLT2) inhibitors have been shown to reduce cardiovascular events T2DM disease. This study aimed investigate effect SGLT2 inhibitor use on adverse renal outcomes AMI. Methods A total 1,268 admitted Care Unit due AMI were retrospectively...
To investigate the correlation between CHADS2 score and risk of contrast-induced nephropathy (CIN), we conducted a retrospective study in patients who underwent elective percutaneous coronary intervention (PCI) compared its accuracy with previous scoring systems. A total 539 PCI were enrolled. Based on their underlying diseases, such as hypertension, diabetes, kidney disease, score, R2CHADS2 Mehran's calculated for each patient. Incidence CIN was defined rise serum creatinine >0.5 mg/dL or...
Objective— Basic research indicates that TNFSF14 (tumor necrosis factor superfamily 14) may be involved in the pathogenesis of atherosclerosis. Given requirements new biomarkers for risk classification coronary artery disease (CAD), we conducted a longitudinal analysis to investigate if levels are associated with cardiovascular events among patients stable CAD. Approach and Results— In total, 894 CAD were enrolled multicenter prospective study. The primary outcome was occurrence death,...
The pathophysiology of sepsis involves inflammation and hypercoagulability, which lead to microvascular thrombosis compromised organ perfusion. Dipeptidyl peptidase (DPP)-4 inhibitors, e.g., linagliptin, are commonly used anti-diabetic drugs known exert anti-inflammatory effects. However, whether these confer an anti-thrombotic effect that preserves perfusion in remains be investigated. In the present study, human umbilical vein endothelial cells (HUVECs) were treated with linagliptin...
Abstract Background Ruling out obstructive coronary artery disease (CAD) using computed tomography angiography (CCTA) is time‐consuming and challenging. This study developed a deep learning (DL) model to assist in detecting CAD on CCTA streamline workflows. Methods In total, 2929 DICOM files 7945 labels were extracted from curved planar reformatted images. A modified Inception V3 was adopted. To validate the artificial intelligence (AI) model, two cardiologists labelled adjudicated...
Activin A and its binding protein follistatin may be crucial in glucose homeostasis, as multifunctional proteins mediating inflammatory anti-inflammatory effects. However, clinical data on the activin level prediabetes, association between circulating carotid intima-media thickness (cIMT), are lacking. We aimed to investigate levels their associations with cIMT. In total, 470 inhabitants of I-Lan county (235 men; mean age 69 ± 9 years) measurements serum were included. Patients prediabetes...
Atrial fibrillation (AF) is associated with an increased risk of dementia. However, limited data are available on the predictors dementia in patients AF. This study aimed to evaluate whether CHADS2 score could be a useful tool for stratification regard occurrence among AF.AF were identified from National Health Insurance sampling database, which has accumulated total 1,000,000 participants since 2000. After excluding diagnosed prior index day enrollment, was measured investigate its...
Patients with diabetes mellitus tend to develop ischemia-related complications and have compromised endothelial progenitor cell (EPC) function. Melatonin protects against ischemic injury, possibly via EPC modulation. We investigated whether melatonin pretreatment could restore function impairment improve circulation recovery in a diabetic critical limb ischemia mouse model. Under 25 mM high-glucose medium vitro, proliferation, nitric oxide production, tube formation, synthase (eNOS)...
Objectives The association between hepatitis B virus (HBV) infection and cardiovascular disease remains uncertain. This study explored long-term hard endpoints (ie, myocardial infarction ischaemic stroke) all-cause mortality in diabetic patients with chronic HBV Taiwan from 2000 to 2013. Design was retrospective, longitudinal propensity score-matched. Setting Nationwide claims data for the period 2000–2013 were retrieved Taiwan’s National Health Insurance Research Database. Participants...
Abstract Aims Patients with high‐flow arteriovenous (AV) access are at risk of developing high‐output cardiac failure (HOCF) and subsequent hospitalization. However, diagnosing HOCF is challenging often requires invasive procedures. The role systemic vascular resistance (SVR) in underestimated, its predictive value limited. Our study aims to identify non‐invasive factors for facilitate early diagnosis timely surgical interventions. Methods results We included 109 patients AV who underwent...
Abstract Galectin-1 modulates acute and chronic inflammation, is associated with glucose homeostasis renal disease. Whether the serum galectin-1 level can predict short-term long-term outcomes after contrast exposure in patients undergoing coronary angiography (CAG) remains uncertain. This study aimed to evaluate relationship between incidence of contrast-induced nephropathy (CIN), investigate predictive role circulating for function decline CAG. In total, 798 who had undergone CAG were...
Abstract Patients with left main coronary artery disease (LMCAD) a high SYNTAX score (SS) were excluded from randomized studies that comparing percutaneous intervention (PCI) and bypass grafting (CABG). We sought to compare PCI CABG in the real-world practice investigate impact of SS I, II, II 2020 on clinical outcomes. In total, 292 LMCAD (173 PCI, 119 CABG) treated between 2017 2021 enrolled. The primary outcome was major adverse cardiovascular events (MACE), composite all-cause death,...