A5072081681- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Drug-Induced Adverse Reactions
- Galectins and Cancer Biology
- Vitamin D Research Studies
- Respiratory and Cough-Related Research
- Gut microbiota and health
- Mast cells and histamine
- Gastrointestinal motility and disorders
- Hepatitis C virus research
- Delphi Technique in Research
- Hepatitis B Virus Studies
- Genomics, phytochemicals, and oxidative stress
- Polydiacetylene-based materials and applications
- Vitamin C and Antioxidants Research
- Viral gastroenteritis research and epidemiology
- Phytochemicals and Antioxidant Activities
- Plant Toxicity and Pharmacological Properties
University of Zurich
2016-2024
Phramongkutklao Hospital
2014-2024
Phramongkutklao College of Medicine
2017-2024
CK-CARE
2016-2021
Chulalongkorn University
2016-2020
Background The involvement of B cells in allergen tolerance induction remains largely unexplored. This study investigates the role this process, by comparing B-cell responses allergic patients before and during immunotherapy (AIT) naturally exposed healthy beekeepers beekeeping season. Methods Circulating were characterized flow cytometry. Phospholipase A2 (PLA)-specific identified using dual-color staining with fluorescently labeled PLA. Expression regulatory B-cell-associated surface...
BackgroundDespite the efficacy of allergen-specific immunotherapy (AIT), role trained immunity and tolerance in this process has not been elucidated.ObjectiveHere, we have performed a comprehensive longitudinal analysis systemic innate immune cell repertoire during course AIT.MethodsPatients with allergy received standard preseasonal subcutaneous AIT allergoids to birch and/or grass. Healthy controls were monitored without any intervention. Flow cytometry lymphoid (ILC), natural killer cell,...
Allergen-specific immunotherapy (AIT) is the only available treatment for allergic diseases that can induce specific immune tolerance to allergens. The key mechanisms involved in this process include changes allergen-specific regulatory T (Treg) cells.We studied 25 rhinitis patients undergoing subcutaneous house dust mite-specific immunotherapy. Peripheral blood mononuclear cells were before and after 10, 30 weeks, 3 years of AIT. Der p 1-specific cell responses investigated by...
Asthma patients present with distinct immunological profiles, a predominance of type 2 endotype. The aim this study was to investigate the impact high-altitude treatment on clinical and response in asthma.Twenty-six hospitalized asthma (nine eosinophilic allergic; EA, nine noneosinophilic NEA eight nonallergic; NN) healthy controls high altitude for 21 days were enrolled study. We assessed eosinophils, T cells, Tregs, innate lymphoid cells (ILC) from peripheral blood using flow cytometry.The...
chronic urticaria
Group 2 innate lymphoid cells (ILC2s) have been implicated in the pathogenesis of allergic disease. However, effect allergen-specific immunotherapy (AIT) on ILCs remains to be clarified. The aim this study was evaluate levels ILC subsets rhinitis (AR) patients response house dust mite (HDM)-specific immunotherapy.We enrolled 37 AR undergoing AIT (16 responders and 11 non-responders) for years, 35 HDM 28 healthy subjects. Peripheral blood mononuclear (PBMCs) were analyzed by flow cytometry...
Abstract Background Immunological traits and functions have been consistently associated with environmental exposures are thought to shape allergic disease susceptibility protection. In particular, specific in early life may more significant effects on the developing immune system, potentially long‐term impacts. Methods We performed RNA‐Seq peripheral blood mononuclear cells (PBMCs) from 150 children atopic dermatitis healthy nonallergic rural urban settings same ethnolinguistic AmaXhosa...
Abstract Background Antigen‐specific memory B cells play a key role in the induction of desensitization and remission to food allergens oral immunotherapy development natural tolerance (NT). Here, we characterized milk allergen Bos d 9‐specific allergen‐specific (OIT) children spontaneously outgrowing cow's allergy (CMA) due NT. Methods Samples from with CMA who received OIT (before, during, after), naturally outgrew (NT), healthy individuals were Stanford biobank. isolated by flow cytometry...
Vitamin D plays an important role in the immune system; decreased serum vitamin concentrations have been linked to dysregulated function. Low status is probably associated with chronic spontaneous urticaria (CSU). We evaluated prevalence of low status, and clinical response quality life following supplementation, a prospective case-control study 60 CSU patients 40 healthy individuals. Serum 25-hydroxy (25(OH)D) were measured at baseline after 6 weeks. For 25(OH)D < 30 ng/ml, treatment...
Previous house dust mite subcutaneous immunotherapy (HDM SCIT) placebo-controlled trials have small sample sizes and lack a consensus on baseline treatment.
Background Autologous serum skin test (ASST) and autologous plasma (APST) are simple methods to diagnose autoimmune chronic urticaria. However, the association data of ASST or APST with disease severity long-term outcome still unclear. Objective The results might be used predict urticaria symptom outcomes among spontaneous (CSU) patients. Methods We evaluated prevalence reactive in 128 CSU patients were characterized by 4 groups: negative, positive, both positive. observed remission rate...
Introduction. Vitamin D deficiency has been linked to an increased risk of asthma exacerbations. Objective. This study aimed compare vitamin status during the period severe exacerbations and investigate if supplementation improves control. Methods. A total 47 asthmatic patients 40 healthy subjects participated in this study. Serum 25-hydroxyvitamin (25(OH)D), control test (ACT) score, % predicted peak expiratory flow rate were evaluated with without After that, we provided D2 supplements low...