A5044447529- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Systemic Lupus Erythematosus Research
- Contact Dermatitis and Allergies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Food Allergy and Anaphylaxis Research
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Viral gastroenteritis research and epidemiology
- Urticaria and Related Conditions
- Skin Protection and Aging
- Sinusitis and nasal conditions
- Immunodeficiency and Autoimmune Disorders
- Pharmacogenetics and Drug Metabolism
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Gut microbiota and health
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
Chulalongkorn University
2015-2024
Oxfam
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
John Wiley & Sons (United Kingdom)
2023
King Chulalongkorn Memorial Hospital
2020-2022
Thai Red Cross Society
2020
Taipei Institute of Pathology
2010
Aja University of Medical Sciences
2010
Interleukin-22 (IL-22) is the effector molecule of T-helper subset 22 (Th-22) lineage that promotes keratinocyte proliferation and dermal inflammation in psoriasis. Methotrexate widely used as a first-line treatment moderate to severe inhibits inflammatory cytokinetic processes via various mechanisms, but relevance these psoriasis limited whether methotrexate specifically able down-regulate Th22 cytokines unknown. To determine if reduces IL-22 cases Nineteen patients with were given 15 mg...
Abstract Background The house dust mite (HDM ) allergen Der p 13 could be a lipid‐binding protein able to activate key innate signaling pathways in the initiation of allergic response. We investigated IgE reactivity recombinant (rDer 13), its activities, and capacity stimulate airway epithelium cells. Methods Purified rDer was characterized by mass spectrometry, circular dichroism, fluorescence‐based assays, silico structural prediction. IgE‐binding activity allergenic potential were...
Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of the epidermal cells and clinically presented as thick, bright red to pink plaques with silvery scale. Photodynamic therapy (PDT) using visible light has become increasing interest in treatment diseases. In this study, we demonstrate that combination curcumin-loaded chitosan/alginate nanoparticles (Cur-CS/Alg NPs) blue emitting diodes (LED) irradiation effectively suppressed tumor necrosis factor-alpha...
Summary The production of cytokine varies among individuals and correlates with the polymorphism genes. Three functional single nucleotide polymorphisms (SNPs) at position –863, –308, –238 in tumour necrosis factor alpha (TNF‐α) gene promoter were analysed for association systemic lupus erythematosus (SLE) ( n = 154), clinical manifestations a Thai population compared 154 ethnically matched controls. genotyping was determined by polymerase chain reaction‐restriction fragment length method....
Abstract Background Major allergenic components of peanut from distinct geographical regions are widely dispersed. Most the diagnostic studies countries with a high prevalence. There have been only few reports allergen component sensitizations low prevalence allergy. We aimed to investigate roles component‐resolved ( CRD ) differentiate allergy and tolerance in A sian population country Methods Participants sensitization were enrolled. Clinical reactions determined. Skin prick test SPT...
Oxyresveratrol (ORV) is one of the novel antioxidants having been extensively studied in recent years. One main sources ORV Artocarpus lakoocha, which has used traditional medicine Thailand for decades. However, role skin inflammation not clearly demonstrated. Therefore, we investigated anti-inflammatory effects on dermatitis model. The effect was examined human immortalized and primary cells exposed to bacterial components including peptidoglycan (PGN) lipopolysaccharide (LPS)...
Previous house dust mite subcutaneous immunotherapy (HDM SCIT) placebo-controlled trials have small sample sizes and lack a consensus on baseline treatment.
Abstract Introduction Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies and immune complex deposition in various organs. Aberrations the T lymphocyte compartment dysregulated cytokine are key features SLE pathogenesis disease progression. Recently, role interleukin (IL)-17/IL-23 axis has been reported. IL-23 IL-23R essential for expansion pathogenic IL-17-producing lymphocytes have shown to be important animal models. Methods In this...
Elucidating transcriptome in the peripheral edge of lesional (PE) skin could provide a better understanding molecules or signalings that intensify inflammation PE skin. Full-thickness biopsies and uninvolved (UN) were obtained from psoriasis patients for RNA-seq. Several potential differentially expressed genes (DEGs) compared to those UN identified. These DEGs enhanced functions such as angiogenesis, growth epithelial tissue, chemotaxis homing cells, connective tissues, degranulation...
Abstract Polymorphism of vascular endothelial growth factor (VEGF) influences the VEGF production and is subjected to genetic susceptibility many diseases including psoriasis. Three single nucleotide polymorphisms (SNPs) within promoter exon 1 region [−2578(C/A), −460(C/T) +405(C/G)] were analyzed in 154 patients with chronic plaque psoriasis 234 ethnically matched healthy controls from Thailand. The CTG (−2578/−460/+405) haplotype frequency was higher early‐onset (44.12%) compared (33.33%)...
Polymorphisms of the IL-10 promoter have been implicated in genetic susceptibility to many autoimmune diseases, including psoriasis. Four putative functional single-nucleotide polymorphisms (SNPs) within interleukin-10 region (-3575T/A, -2763A/C, -1082G/A and -592C/A) were analysed 139 patients with chronic plaque psoriasis 155 unrelated healthy controls from Thailand. There no significant differences allele frequencies any four SNPs between controls. However, frequency -2763A was increased...
Psoriasis is a chronic inflammatory skin disease arising from complex interaction between genetics, epigenetics, the host's immune system and environment. Recent accumulated data revealed dysregulation of various microRNAs (miRNAs) in several diseases including psoriasis.We explored functional role regulation hsa-miR-155-5p (miR-155) an immortalized keratinocyte cell line (HaCaT), relation to pathogenesis treatment psoriasis.miR-155 expression normal psoriatic lesion before after with...
Seborrheic dermatitis (SD) is a chronic inflammatory skin condition that occurs in body areas contain profuse sebaceous glands. Skin microbiota are diverse across ethnic groups and its dysbiosis has been implicated the pathogenesis of SD. Here, we reported contribution cutaneous bacterial to SD Thai population. Healthy individuals patients with scalp were recruited into study. Normal skin, lesion (SL) non-lesion sites (SNL) samples collected using tape stripping method next-generation...