A5005660859- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Rabies epidemiology and control
- Cancer Genomics and Diagnostics
- Pituitary Gland Disorders and Treatments
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Histiocytic Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Epilepsy research and treatment
- Venomous Animal Envenomation and Studies
- Meningioma and schwannoma management
- Streptococcal Infections and Treatments
- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Adrenal and Paraganglionic Tumors
- Neurofibromatosis and Schwannoma Cases
- Oral and Maxillofacial Pathology
King Chulalongkorn Memorial Hospital
2013-2025
Chulalongkorn University
2016-2025
Ministry of Public Health
2005-2025
Jewish General Hospital
2024
Faculty (United Kingdom)
2019
Zoological Park Organization
2016
Thai Red Cross Society
2012
Bangkok Hospital
2011
National Institutes of Health
2002-2005
Siriraj Hospital
2003
The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutation-positive non-small-cell lung cancer (NSCLC) patients necessitates accurate, timely testing. Although mutation testing has been adopted by many laboratories Asia, data are lacking on the proportion NSCLC tested each country, and most commonly used methods.A retrospective survey records from for mutations during 2011 was conducted 11 Asian Pacific countries at 40 sites that routinely performed...
This study evaluated methylation patterns of long interspersed nuclear element-1 (LINE-1) sequences from 17 loci in several cell types, including squamous cancer lines, normal oral epithelium (NOE), white blood cells and head neck cancers (HNSCC). Although each LINE-1 are homologous, levels at locus different. Moreover, some demonstrate the different between tissue types. Interestingly, chromosomal regions, wider ranges were observed. In cancerous cells, most demonstrated a positive...
Pituitary blastoma causing Cushing's syndrome in infancy is very rare, and its molecular pathomechanism not well understood. Our objective was to identify genetic changes of a pituitary infantile-onset Thai girl without family history cancers. Genomic DNA from both leukocytes tumor tissues used for whole-exome sequencing (WES) Sanger DICER1. The cDNA reverse-transcribed RNA extracted sequencing, quantitative real-time PCR (qRT-PCR), pyrosequencing WES identified novel heterozygous c.3046delA...
The aim of our study is to describe the unusual clinical manifestations smooth-muscle tumors (SMTs) in patients with acquired immunodeficiency virus (AIDS) and demonstrate association between Epstein-Barr (EBV) infection SMTs.Nine AIDS SMTs were characterized at Chulalongkorn Hospital (Bangkok, Thailand) from 2001 through 2003. Tumor tissues suitable for immunohistochemical analysis situ hybridization assayed EBV, respectively. Plasma serum samples tested EBV by real-time quantitative...
Abstract Despite the development of predictive biomarkers to shape treatment paradigms and outcomes, de novo EGFR TKI resistance advanced non-small cell lung cancer (NSCLC) remains an issue concern. We explored clinical factors in 332 NSCLC who received molecular characteristics through 65 whole exome sequencing various responses including; (progression within 3 months), intermediate response (IRs) long-term (LTRs) (durability > 2 years). Uncommon mutation subtypes were significantly...
Published research on the clinicopathologic features of extraventricular ependymal neoplasms cerebral hemispheres has been scant.Thirty-two archival cases were studied to investigate prognostic impact parameters including flow cytometry, proliferation (Ki-67) labeling index, and p53 expression.Among these 32 2 subependymomas, 19 ependymomas, 11 anaplastic ependymomas. No significant gender predilection was observed, 45% patients in their second or third decade life. The left hemisphere 1.5...
Data on encephalitis in Thailand have not been completely described. Etiologies remain largely unknown. We prospectively analyzed 103 Thai patients from 27 provinces for the causes of using clinical, microbiological and neuroimaging indices; caseswithout a diagnosis were evaluated autoimmune encephalitis. Patients with and/or myelitis studied between October 2010 August 2012. Cases associated bacterial, rickettsial mycobacterial diseases excluded. Herpes viruses 1-6 enteroviruses infection...
The mechanisms that differentiate rabies infections into furious and paralytic forms remain undetermined. There are no neuropathological features in human brains distinguish rabies. This could be due to methodology and/or examination of specimens late the disease course. In this study, postmortem brain (5 5 paralytic) spinal cord (3 3 was performed 10 rabies-infected dogs, sacrificed shortly after developing illness. Rabies virus (RABV) antigen (percentage positive neurons, average area...
EGFR-TKIs are effective therapies for non–small cell lung cancer (NSCLC) patients with EGFR-activating mutations. However, responses vary within individuals and resistant disease inevitably emerges. A prospective cohort of 130 advanced EGFR mutation NSCLC were enrolled. Pre-and post-treatment plasma from subjects treated obtained. The correlation between abundance using the Idylla™ ctEGFR assay, radiographic assessment, clinical outcomes analyzed. Eighty-nine retrieved blood collection...
Anthracyclines are essential in early breast cancer chemotherapy but pose long-term cardiotoxicity risks. This study aims to investigate the incidence of therapy-related cardiac dysfunction (CTRCD), bridging with miRNAs profiler representing acute injury. We conducted a prospective cohort including stage I-III patients who received anthracycline between 2007 and 2012. Echocardiography was performed before 12 weeks after administration. The by NanoString RT-PCR. Long-term magnetic resonance...