A5070069073- Coral and Marine Ecosystems Studies
- Diet and metabolism studies
- Marine Sponges and Natural Products
- Vector-borne infectious diseases
- Marine and coastal plant biology
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Nail Diseases and Treatments
- Cellular transport and secretion
- Leptospirosis research and findings
- Bacteriophages and microbial interactions
- Tryptophan and brain disorders
- CRISPR and Genetic Engineering
- Arsenic contamination and mitigation
- Microbial bioremediation and biosurfactants
- Complementary and Alternative Medicine Studies
- Dermatology and Skin Diseases
- Mosquito-borne diseases and control
- Photosynthetic Processes and Mechanisms
- Insect symbiosis and bacterial influences
- Advanced Fluorescence Microscopy Techniques
- Clinical Nutrition and Gastroenterology
- Probiotics and Fermented Foods
- Microbial Fuel Cells and Bioremediation
Mahidol Oxford Tropical Medicine Research Unit
2023-2025
Mahidol University
2023-2025
Chulalongkorn University
2021-2022
Chulabhorn Graduate Institute
2019
Abstract Obesity, a major healthcare problem worldwide, induces metabolic endotoxemia through the gut translocation of lipopolysaccharides (LPS), cell wall component Gram-negative bacteria, causing chronic inflammatory state. A combination several probiotics including Lactobacillus acidophilus 5 (LA5), potent lactic acid-producing bacterium, has previously been shown to attenuate obesity. However, data on correlation between single administration LA5 versus microbiota alteration might be...
The impact of fungi in the intestine on acute uremia was demonstrated by oral administration Candida albicans mice with removal both kidneys. Because mouse are less abundant than humans, a -administered model has more resemblance to patient conditions.
Abstract Orientia tsutsugamushi is an obligate intracellular bacterium found in Leptotrombidium mites that causes the human disease scrub typhus. A distinguishing feature of O. its extensive strain diversity, yet differences virulence between strains are not well defined nor understood. We sought to determine bacterial drivers pathogenicity by comparing murine infections using seven combined with epidemiological data rank each terms relative virulence. Murine cytokine expression revealed two...
Global warming has caused elevated seawater temperature and coral bleaching, including events on shallow reefs in the upper Gulf of Thailand (uGoT). Previous studies have reported an association between loss zooxanthellae bleaching. However, microbial diversity prokaryotes eukaryotes (microbiome) as holobionts are also important this information is still limited uGoT. To address shortcoming, report provided baseline prokaryotic (bacteria archaea) eukaryotic microbes healthy bleached colonies...
Obligate intracellular bacteria, or those only capable of growth inside other living cells, have limited opportunities for horizontal gene transfer with microbes due to their isolated replicative niche. The human pathogen Ot, an obligate bacterium causing scrub typhus, encodes unusually high copy number a ~40 mobile genetic element that typically facilitates across microbes. This proliferated is heavily degraded in Ot and previously assumed be inactive. Here, we conducted detailed analysis...
As seawater temperature rises, repeated thermal bleaching events have negatively affected the reefs of Andaman Sea for over decades. Studies on coral-associated microbial diversity prokaryotes and eukaryotes (microbiome) in healthy bleached corals are important to better understand coral holobionts that involved augmented resistance stresses, this information remains limited Thailand. The present study thereby described microbiomes (unbleached) colonies four prevalent corals, Acropora...
Seborrheic dermatitis (SD) is a chronic inflammatory skin condition that occurs in body areas contain profuse sebaceous glands. Skin microbiota are diverse across ethnic groups and its dysbiosis has been implicated the pathogenesis of SD. Here, we reported contribution cutaneous bacterial to SD Thai population. Healthy individuals patients with scalp were recruited into study. Normal skin, lesion (SL) non-lesion sites (SNL) samples collected using tape stripping method next-generation...
ABSTRACT The intracellular bacterium Orientia tsutsugamushi relies on the microtubule cytoskeleton and motor protein dynein to traffic perinuclear region within infected cells. However, it remains unclear how is coupled machinery transport regulated. Here, we discover that O. uses its autotransporter ScaC recruit adaptor BICD2 bacterial surface. We show sufficient engage dynein-based motility in absence of other proteins required for efficient movement during infection. Using TIRF...
Probiotics are known for health-promoting microorganisms, examples, assisting gastrointestinal digestion and short chain fatty acid producers. Several current oral human probiotics were derived from samples; yet, of various ethnic (genetics) dietary patterns. As similar pattern might confer certain advantages (e.g., more compatibility with hosts), this study isolated characterized healthy Thai adults. To screen potential probiotic isolates adult feces, preliminary characterize these by...
Abstract The rickettsial human pathogen Orientia tsutsugamushi (Ot) is an obligate intracellular Gram-negative bacterium with one of the most highly fragmented and repetitive genomes any organism. Around 50% its ∼2.3 Mb genome comprised DNA that derived from proliferated Rickettsiales amplified genetic element (RAGE). RAGE integrative conjugative (ICE) present in a single Ot up to 92 copies, which are partially or heavily degraded. In this report, we analysed RAGEs eight fully sequenced...
Abstract A symbiosis of bacterial community (sometimes called microbiota) play essential roles in developmental life cycle and health coral, starting since a larva. For examples, coral holobionts function nitrogen fixation, carbon supply, sulfur cycling antibiotic production. Yet, study the dynamic bacteria associated larvae development is complicated owning to vast diversity culturable difficulty bacteria; hence this type remains unexplored for Acropora humilis Thai sea. This represented...
The Agrobacterium tumefaciens ActSR two-component regulatory system is a member of homologous group global redox-responsive systems that adjust the expression energy-consuming and energy-supplying metabolic pathways in order to maintain cellular redox balance. In this study, transcriptional organization hrpB-actSR locus was determined effect actSR inactivation on stress resistance investigated. It found hrpB transcribed as monocistronic mRNA actS along with actR bicistronic mRNA, while also...