A5080831504- Meningioma and schwannoma management
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Neurofibromatosis and Schwannoma Cases
- Growth Hormone and Insulin-like Growth Factors
- RNA Research and Splicing
- Vestibular and auditory disorders
- MRI in cancer diagnosis
- Thyroid Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Fungal Infections and Studies
- Lymphoma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Geophysics and Sensor Technology
- Polyomavirus and related diseases
- Endometrial and Cervical Cancer Treatments
- Glycosylation and Glycoproteins Research
- Hematological disorders and diagnostics
- Virus-based gene therapy research
- Ocular Oncology and Treatments
Krankenhaus Dresden-Friedrichstadt
2023
Martin Luther University Halle-Wittenberg
2012-2021
University Hospital in Halle
2018-2020
Halle Zoo
2018
Hepatocarcinogenesis is a stepwise process. It involves several genetic and epigenetic alterations, e.g., loss of tumor suppressor gene expression ( TP53, PTEN, RB ) as well activation oncogenes (c - MYC, MET, BRAF, RAS ). However, the role RNA-binding proteins (RBPs), which regulate oncogene at posttranscriptional level, are not understood in hepatocellular carcinoma (HCC). Here we analyzed RBPs induced human liver cancer, revealing 116 with significant more than 2-fold higher HCC compared...
Pre-surgical diffusion weighted imaging (DWI) is increasingly important in the context of thyroid cancer for identification optimal treatment strategy. It has exemplarily been shown that DWI at 3T can distinguish undifferentiated from well-differentiated carcinoma, which decisive implications magnitude surgery. This study used histogram analysis whole tumor apparent coefficient (ADC) maps. The primary aim was to discriminate carcinomas had already gained capacity metastasize lymphatically...
The oncofetal IGF2 mRNA-binding protein 1 (IGF2BP1) controls the migration and invasiveness of primary as well tumor-derived cells in vitro. Whether also modulates epithelial-mesenchymal-transition (EMT), a hallmark tumor progression involved cell dissemination, remained elusive. In this study, we reveal that IGF2BP1 enhances mesenchymal-like properties by promoting expression transcriptional regulators LEF1 SLUG (SNAI2). associates with transcripts prevents their degradation...
Intralabyrinthine schwannomas (ILS) are a rare differential diagnosis of sudden hearing loss and vertigo. In an own case series 12 patients, 6 tumors showed intracochlear, 3 intravestibular, 1 transmodiolar including the cerebellopontine angle (CPA), 1a transotic CPA, multilocular location. The were removed surgically in 9 whereas patients decided for "wait-and-test-and-scan" strategy. Of surgical underwent labyrinthectomy cochlear implant (CI) surgery single-stage procedure; patient had...
Anaplastic thyroid carcinomas (ATC) are rare, but represent the most lethal malignancy of thyroid. Selective molecular markers and drivers distinguishing ATC from other follicular origin remain largely unknown, limiting advances in diagnosis treatment. In a retrospective study, we analyzed gene expression 36 ATC, 18 poorly differentiated, 132 papillary, 55 carcinoma, as well 124 paired unpaired normal tissues three independent cohorts by RNA-sequencing immunohistochemistry. data test cohort...
Epithelial-to-mesenchymal transition (EMT) is a hallmark of aggressive, mesenchymal-like high-grade serous ovarian carcinoma (HGSOC). The SRC kinase key driver cancer-associated EMT promoting adherens junction (AJ) disassembly by phosphorylation-driven internalization and degradation AJ proteins. Here, we show that the IGF2 mRNA-binding protein 1 (IGF2BP1) up-regulated in HGSOC promotes activation previously unknown protein-ligand-induced, but RNA-independent mechanism. IGF2BP1-driven...
Y RNAs constitute a family of highly conserved small noncoding (in humans: 83-112 nt; Y1, Y3, Y4 and Y5). They are transcribed from individual genes by RNA-polymerase III fold into stem-loop-structures. Although discovered 30 years ago, insights the cellular physiological role remains incomplete. In this review, we will discuss knowledge on structural properties, associated proteins proposed functions RNAs. We suggest to be an integral part ribonucleoprotein networks within cells could...
Diffusion-weighted imaging is able to reflect histopathology architecture. A novel approach, namely histogram analysis, used further characterize lesion on MRI. To correlate parameters derived from apparent diffusion coefficient (ADC) maps with in muscle lymphoma.Eight patients (mean age 64.8 years, range 45-72 years) histopathologically confirmed lymphoma were retrospectively identified. Cell count, total nucleic and average areas estimated using ImageJ. Additionally, Ki67-index was...
Cryptococcosis in immunocompetent adults is a rare disease Europe, mostly induced by members of the Cryptococcus gattii species complex. The diagnosis can be challenging due to its rarity, unspecific symptoms and long symptomless latency.A 49-year-old woman with three weeks history headache was admitted hospital discrete ataxia impaired vision. Cranial magnetic resonance imaging (MRI) showed contrast-enhancing mass cerebellum. Further investigations detected slight leukocytosis single...
Biomedical research and quality control procedures often demand a variety of microscopic analysis numerous formalin-fixed paraffin-embedded (FFPE) tissue samples from different individuals both healthy diseased regions interest. Depending on the number to be analyzed, conventional processing each FFPE block separately can laborious or impracticable. This effort drastically reduced by using microarrays (TMAs). TMAs have wide range applications considered as high-throughput method process up...
Abstract Epithelial-to-mesenchymal transition (EMT) is a hallmark of aggressive, mesenchymal-like high-grade serous ovarian carcinoma (HG-SOC). The SRC kinase key driver cancer-associated EMT promoting adherens junction (AJ) disassembly by phosphorylation-driven internalization and degradation AJ proteins. Here we show, that the IGF2 mRNA binding protein 1 (IGF2BP1) up-regulated in HG-SOC promotes activation previously unknown protein-ligand-induced, but RNA-independent mechanism....
Insulin-like growth factor 2 binding proteins 1, und 3 (IGF2BP1,2,3) gehören zu einer Familie von onkofetalen mRNA-bindenden Proteinen, die onkogene Zieltranskripte vor miRNA-vermitteltem Abbau schützen damit an zellulären Vorgängen wie Zellpolarität, Migration Proliferation beteiligt sind. Die Proteinexpression IGF2BP1 wird in Gewebe Ovarialkarzinomen analysiert den klinischen pathologischen Daten korreliert.
Intralabyrinthine schwannomas (ILS) are a rare differential diagnosis of sudden hearing loss and vertigo.
Intralabyrinthäre Schwannome (ILS) sind eine seltene Differenzialdiagnose des Hörsturzes und von Schwindelbeschwerden.