A5009506955- Meningioma and schwannoma management
- Facial Nerve Paralysis Treatment and Research
- Neurofibromatosis and Schwannoma Cases
- Reinforcement Learning in Robotics
- Trigeminal Neuralgia and Treatments
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Ophthalmology and Eye Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Cleft Lip and Palate Research
- Vestibular and auditory disorders
- Venous Thromboembolism Diagnosis and Management
- Transportation and Mobility Innovations
- Natural Language Processing Techniques
- Linguistic Variation and Morphology
- Nerve injury and regeneration
- Glioma Diagnosis and Treatment
- Speech Recognition and Synthesis
- Vehicle Routing Optimization Methods
- Cerebrospinal fluid and hydrocephalus
- Adversarial Robustness in Machine Learning
- Brain Metastases and Treatment
- Railway Systems and Energy Efficiency
Martin Luther University Halle-Wittenberg
2016-2025
University Hospital in Halle
2012-2024
FHNW University of Applied Sciences and Arts
2020-2023
Klinikum Bremerhaven-Reinkenheide
2022-2023
University Hospital Magdeburg
2023
University of Göttingen
2022
Wittenberg University
2019-2022
Klinik und Poliklinik für Neurologie
2018-2020
Leipzig University
2014
Universität Ulm
2006-2008
Reinforcement learning (RL) has been successful in training agents various environments, including video games. However, such work modifies and shrinks the action space from game's original. This is to avoid trying "pointless" actions ease implementation. Currently, this mostly done based on intuition, with little systematic research supporting design decisions. In work, we aim gain insight these modifications by conducting extensive experiments game environments. Our results show how...
Nimodipine is the current gold standard in treatment of subarachnoid hemorrhage, as it only known calcium channel blocker that has been proven to improve neurological outcomes. In addition, nimodipine exhibits neuroprotective properties vitro under various stress conditions. Furthermore, clinical studies have demonstrated a effect after vestibular schwannoma surgery. However, molecular mode action pre-treatment not well investigated. present study, using real-time cell death assays, we...
OBJECTIVE Facial nerve paresis and hearing loss are common complications after vestibular schwannoma surgery. Experiments with facial nerves of the rat retrospectively analyzed clinical studies showed a beneficial effect vasoactive treatment on preservation cochlear functions. This prospective open-label randomized pilot study is first prophylactic in METHODS Thirty patients were before One group (n = 14) received prophylaxis consisting nimodipine hydroxyethylstarch which was started day...
In Brief OBJECTIVE Damage to the facial nerve during surgery in cerebellopontine angle is indicated by A-trains, a specific electromyogram pattern. These A-trains can be quantified parameter "traintime," which reliably correlated with postoperative functional outcome. The system presented was designed monitor traintime real-time. METHODS A dedicated hardware and software platform for automated continuous analysis of intraoperative specifically designed. automatic detection performed...
A pilot study of prophylactic nimodipine and hydroxyethyl starch treatment showed a beneficial effect on facial cochlear nerve preservation following vestibular schwannoma (VS) surgery. prospective Phase III trial was undertaken to confirm these results.An open-label, 2-arm, randomized parallel group multicenter with blinded expert review performed included 112 patients who underwent VS surgery between January 2010 February 2013 at 7 departments neurosurgery investigate the efficacy safety...
Efficient automated scheduling of trains remains a major challenge for modern railway systems. The underlying vehicle rescheduling problem (VRSP) has been focus Operations Research (OR) since decades. Traditional approaches use complex simulators to study VRSP, where experimenting with broad range novel ideas is time consuming and huge computational overhead. In this paper, we introduce two-dimensional simplified grid environment called "Flatland" that allows faster experimentation. Flatland...
Abstract OBJECTIVE: Facial nerve paresis and hearing loss are common complications after vestibular schwannoma surgery. Experimental clinical studies point to a beneficial effect of nimodipine hydroxyethyl starch for preservation cochlear function. A retrospective analysis was undertaken evaluate the vasoactive treatment on facial outcome. PATIENTS AND METHODS: Forty-five patients with removal, intraoperative electromyographic monitoring, postoperative deterioration function were evaluated....
Object: Delayed facial nerve paresis is a well known clinical phenomenon following acoustic neuroma surgery, typically occurring early during the postoperative course. The course of delayed and intraoperative electromyographic (EMG) signals were evaluated in subgroup patients who underwent vasoactive treatment for preservation hearing developed secondary deterioration after termination treatment. Methods: Between 1990 2001 seven identified received medication. Intraoperative EMG activity was...
The incidence of deep venous thrombosis (DVT) after craniotomy is reported to be as high 50%. In outpatients, D-dimer levels more than 0.5 mg/L indicate thromboembolism (VTE, which subsumes DVT and pulmonary embolism [PE]) with a sensitivity 99.4% specificity 38.2%. However, are believed unreliable in postoperative patients. authors undertook the present study test hypothesis that would systematically raised population define feasible threshold for identification VTE.Doppler ultrasonography...
Nimodipine is a Ca2+-channel antagonist mainly used for the management of aneurysmal subarachnoid hemorrhage (aSAH) to prevent cerebral vasospasms. However, it not clear if better outcome nimodipine-treated patients due vasodilatation or whether other cellular neuroprotective neuregenerative effects nimodipine are involved. We analysed PC12 cells after different stress stimuli with without pretreatment. Cytotoxicity 200 mM EtOH and osmotic (450 mosmol/L) was significantly reduced...
OBJECTIVE Patient positioning in vestibular schwannoma (VS) surgery is a matter of ongoing discussion. Factors to consider include preservation cranial nerve functions, extent tumor resection, and complications. The objective this study was determine the optimal patient VS surgery. METHODS A subgroup analysis randomized, multicenter trial that investigated efficacy prophylactic nimodipine performed investigate impact (semisitting or supine) on functional outcomes, data 97 patients were...
Nimodipine is well characterized for the management of SAH (subarachnoid hemorrhage) and has been shown to promote a better outcome less DIND (delayed ischemic neurological deficits). In rat experiments, enhanced axonal sprouting higher survival motoneurons was demonstrated after cutting or crushing facial nerve by nimodipine. These results were confirmed in clinical trials following vestibular Schwannoma surgery. The mechanism protective competence nimodipine unknown. Therefore, this study,...
Clinical and experimental data assumed a neuroprotective effect of the calcium channel blocker nimodipine. However, it has not been proven which neuronal or glial cell types are affected by nimodipine mechanisms underlie these effects. Therefore, aim this study was to investigate influence treatment on in vitro neurotoxicity different various stress models identify associated molecular mechanisms. lines from Schwann cells, cells astrocytes were pretreated for 24 h with incubated under...
The term "venous thromboembolism" (VTE) subsumes deep venous thrombosis (DVT) and pulmonary embolism. incidence of DVT after craniotomy was reported to be as high 50%. Even clinically silent may lead potentially fatal risk VTE is correlated with duration surgery, it appears likely that develops during surgery. present study aimed evaluate intraoperative use intermittent pneumatic compression (IPC) the lower extremity for prevention in patients undergoing craniotomy.
The chemotherapeutic agent vincristine is commonly used for a variety of hematologic cancers, as well solid tumors the head and neck, bronchial carcinoma, part procarbazine, lomustine (PCV) regimen, glioma. Damage to nerve tissue (neuropathy) often dose-limiting restricts treatment. Nimodipine calcium antagonist that has also shown neuroprotective properties in preliminary studies. In this approach here, we investigated effects combination nimodipine on three cancer cell lines (A549, SAS...
Object: Continuous recording of electromyographic signals (EMG) is a standard method for intraoperative monitoring facial nerve function in cerebello-pontine angle surgery. Subcutaneous needle electrodes the muscles are used different setups. The goal this study was to compare two commonly electrode setups concering sensitivity pathological EMG activity.
Eagle's syndrome is caused by an elongated or mineralised styloid process and characterised facial pharyngeal pain, odynophagia dysphagia. Diagnosis based on clinical findings. However radiologic imaging, like panoramic radiograph, helps to confirm the diagnosis. There are different treatments of syndrome. Anti-inflammatory medication (carbamazepime, corticosteroids) and/or surgical interventions established. The aim techniques resect near skull base.A transoral, retromolar, para-tonsillar...
<b>Background and Study Aims/Object</b> Oral nimodipine improves neurologic outcome after aneurysmal subarachnoid hemorrhage. In addition, the neuroprotective efficacy of has been revealed following skull base, laryngeal, maxillofacial surgery. Pharmacokinetic investigations showed to reach higher serum levels parenteral versus enteral administration. Furthermore, a correlation between in serum, cerebrospinal fluid, nerve tissue could be quantified. These observations raise question whether...
Vestibular schwannoma is the most common benign tumor of cerebellopontine angle and originates from Schwann cells surrounding vestibulocochlear nerve. Since size VS varies widely, affected patients suffer symptoms varying severity. It often difficult to determine optimal time for therapy, due unpredictability growth rate. Despite many investigations on influencing factors, no mechanism responsible increase in rate certain has been identified so far. Therefore, present study investigates...