A5000377274- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Meningioma and schwannoma management
- Metabolism and Genetic Disorders
- Facial Nerve Paralysis Treatment and Research
- Sinusitis and nasal conditions
- Medical Practices and Rehabilitation
- Ophthalmology and Eye Disorders
- Bone health and treatments
- Nasal Surgery and Airway Studies
- Cerebral Venous Sinus Thrombosis
- Glaucoma and retinal disorders
- Biomedical Research and Pathophysiology
- Parathyroid Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Connective tissue disorders research
- Neurofibromatosis and Schwannoma Cases
- Hemoglobinopathies and Related Disorders
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Noise Effects and Management
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
Martin Luther University Halle-Wittenberg
2016-2025
University Hospital in Halle
2015-2024
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2014-2024
Medical University of Vienna
2000-2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2015-2024
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2005-2024
Wittenberg University
2014-2023
Medizinische Hochschule Hannover
2022
Leipzig/Halle Airport
2021
Stuttgart Observatory
2021
Abstract Recent data suggest that chronic tinnitus is a “phantom auditory perception” caused by maladaptive neuroplasticity and subsequent hyperactivity in an extended neuronal network including the primary cortex, higher‐order association areas, parts of limbic system. It was suggested attenuation this tinnitus‐associated may offer rational option for lasting reduction. Here, we tested hypothesis loudness can be attenuated low‐frequency repetitive transcranial magnetic stimulation (rTMS)...
Hypothesis: Local application of dexamethasone-21-dihydrogen-phosphate (Dex-P) to the round window (RW) membrane guinea pigs produces a substantial basal-apical concentration gradient in scala tympani (ST) perilymph. Background: In recent years, intratympanically applied glucocorticoids are increasingly being used for treatment inner ear disease. Although measurements intracochlear concentrations after RW exist, there is limited information on distribution these drugs fluids. It has been...
Tinnitus has been shown to respond modulations of cortical activity by high-frequency and low-frequency repetitive transcranial magnetic stimulation (rTMS).To determine the tinnitus-attenuating effects a 2-week daily regimen rTMS, navigated maximum tinnitus-related increase in regional cerebral blood flow.Six patients with chronic tinnitus were enrolled this sham-controlled crossover study treated 2x2 weeks suprathreshold 1 Hz rTMS (30 min) applied region maximal flow delineated functional...
Abstract Objectives: To study the safety and efficacy of continuous intratympanic dexamethasone‐phosphate (Dex‐P) for severe to profound sudden idiopathic sensorineural hearing (ISSHL) or anacusis after failure systemic therapy. Study Design: Randomized, double‐blind, placebo controlled multicenter trial. Methods: Patients with ISSHL insufficient recovery (mean 4PTA = 97 dB HL) high dose glucocorticoid therapy received either Dex‐P (4mg/ml) (NaCl 0.9%) continuously applied 14 days into round...
Daily-life conversation relies on speech perception in quiet and noise. Because of the COVID-19 pandemic, face masks have become mandatory many situations. Acoustic attenuation sound pressure by mask tissue reduces ability, especially noisy Masks also can impede process comprehension concealing movements mouth, interfering with lip reading. In this prospective observational, cross-sectional study including 17 participants normal hearing, we measured influence acoustic caused medical (mouth...
Nowadays, several options are available to treat patients with conductive or mixed hearing loss. Whenever surgical intervention is not possible contra-indicated, and amplification by a conventional device (e.g., behind-the-ear device) feasible, then implantable devices an indispensable next option. Implantable bone-conduction middle-ear implants have advantages but also limitations concerning complexity/invasiveness of the surgery, medical complications, effectiveness. To counsel patient,...
Although sudden sensorineural hearing loss (SSNHL) is a serious condition, there are currently no approved drugs for its treatment. Nevertheless, growing understanding that the cochlear pathologies underlie SSNHL include apoptotic death of sensory outer hair cells (OHCs) as well ribbon synapses connecting inner (IHCs) and neurites auditory nerve, designated synaptopathy. Noise-induced (NIHL) common subtype widely used to model preclinically. Here, we demonstrate single interventive...
Intratympanic (IT) delivery of drugs to the ear is increasingly used for both clinical and research purposes. One limitation IT that are rapidly lost from middle by a number processes, so prolonged drug technically difficult. In present study, characteristics poloxamer hydrogel formulation containing dexamethasone (dex) were evaluated. The gel liquid at room temperature, allowing injection, but transitions body providing residence time in ear. A 50-µl volume control or dex-containing...
Drugs applied to the middle ear enter perilymph through bony otic capsule.Drugs intratympanically in humans are thought cochlea primarily round window membrane (RWM). Local drug treatments of commonly evaluated rodent models. The capsule is much thinner at cochlear apex rodents than humans. We therefore investigated whether drugs could as well RWM.The distribution gentamicin and marker trimethylphenylammonium (TMPA) along guinea pig was assessed with sequential apical sampling after 2...
Background: Patients with single-sided deafness (SSD) suffer from reduced binaural hearing (i.e., sound localization and speech in noise discrimination). Cochlear implantation has recently been introduced for patients SSD, as an alternative to devices that employ contralateral routing of the signal. Application children also started. Methods: We retrospectively analyze a case series 4 17 adults treated cochlear implantation. The outcome adult was compared control group 27 bilateral profound...
Risk factors for oropharyngeal dysphagia (OD) in elderly patients are mainly central nervous system (CNS) and structural organic diseases or presbyphagia. We analysed the OD prevalence association of with multimorbidity polypharmacy using real-life data to complete this spectrum, a focus on further iatrogenic risk. This was cross-sectional retrospective study based random sample 200 admitted geriatric hospital. Data analysis included diagnoses, detailed list drugs, an intense clinical...
Cyclic congestion and decongestion in the two nasal cavities is seen connection with respiratory function of nose. The turbulent behavior airflow a prerequisite for adequate contact inspired air particles mucosa. aim this study was to gain insight into during cycle.The cycle 10 healthy human subjects investigated using endoscopic imaging, rhinoresistometry, acoustic rhinometry every 20 minutes over time period up 15 hours. following parameters were recorded each cavity: resistance, hydraulic...
Hypothesis That a theoretical basis for quantifying drug distribution in the inner ear with local applications can be established. Background As methods of delivery to gain wider clinical acceptance it becomes important establish how drugs are distributed as function time and different methods. Methods The course gentamicin concentration fluids was simulated program that considered general pharmacokinetic principles incorporated dimensions dispersal processes, including diffusion, clearance,...
Abstract Objectives: The distribution of gentamicin along the fluid spaces cochlea after local applications has never previously been demonstrated. Computer simulations have predicted that significant basal‐apical concentration gradients might be expected, and histologic studies indicate hair cell damage is greater at base than apex application. In present study, were measured. Methods: A recently developed method sampling perilymph from cochlear guinea pigs was used in which samples...
Muckle-Wells syndrome (MWS) is an inherited autoinflammatory disease characterized by fevers, rashes, arthralgia, conjunctivitis, and sensorineural hearing loss. In MWS, NLRP3 gene mutations are associated with excessive interleukin-1 release. The aims of this study were to determine the otologic characteristics define trajectories loss, explore association distinct genotypes.A prospective observational cohort children adults diagnosed as having MWS was conducted at a single center....
The goal of this study was to develop an appropriate methodology apply drugs quantitatively the perilymph ear. Intratympanic applications inner ear often result in variable drug levels and can only be used for molecules that readily permeate round window (RW) membrane. Direct intracochlear intralabyrinthine application procedures drugs, genes or cell-based therapies bypass tight boundaries at RW, oval window, otic capsule blood-labyrinth barrier. However, perforations release pressure,...