A5088049440- Breast Cancer Treatment Studies
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer Treatment and Pharmacology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Protease and Inhibitor Mechanisms
- Multiple Myeloma Research and Treatments
- HER2/EGFR in Cancer Research
- Cystic Fibrosis Research Advances
- Cerebral Venous Sinus Thrombosis
- Bacterial Infections and Vaccines
- Schizophrenia research and treatment
- Treatment of Major Depression
- Health and Medical Studies
- Neurological disorders and treatments
- Glaucoma and retinal disorders
- Coronary Interventions and Diagnostics
- Transcranial Magnetic Stimulation Studies
- Breast Lesions and Carcinomas
- Anesthesia and Pain Management
- Cardiac Arrest and Resuscitation
- Intraperitoneal and Appendiceal Malignancies
Robert Bosch Hospital
2003-2024
Zimmer Biomet (Germany)
2009-2023
Robert Bosch Stiftung
2022-2023
Robert Bosch (Germany)
2022-2023
University of Tübingen
2001-2021
University Children's Hospital Tübingen
2007-2020
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2011-2018
Kreiskliniken Reutlingen
2017
Marienhospital Stuttgart
2013
Radboud University Nijmegen
2006-2009
Background: Most patients with lymph node-negative breast cancer are cured by locoregional treatment; however, about 30% relapse. Because traditional histomorphologic and clinical factors fail to identify the high-risk who may benefit from adjuvant chemotherapy, other prognostic needed. In a unicenter study, we have found that levels of urokinase-type plasminogen activator (uPA) inhibitor type 1 (PAI-1) in primary tumor predictive disease recurrence. Thus, designed Chemo N0 prospective...
Abstract T cell immunity is central for the control of viral infections. CoVac-1 a peptide-based vaccine candidate, composed SARS-CoV-2 epitopes derived from various proteins 1,2 , combined with Toll-like receptor 1/2 agonist XS15 emulsified in Montanide ISA51 VG, aiming to induce profound combat COVID-19. Here we conducted phase I open-label trial, recruiting 36 participants aged 18–80 years, who received single subcutaneous vaccination. The primary end point was safety analysed until day...
Gait and balance disturbances typically emerge in advanced Parkinson's disease with generally limited response to dopaminergic medication subthalamic nucleus deep brain stimulation. Therefore, programming interleaved pulses was put forward introduce concomittant nigral stimulation on caudal contacts of a lead. Here, we hypothesized that the combined substantia nigra pars reticulata improves axial symptoms compared standard Twelve patients were enrolled this 2 × cross-over double-blind...
Pseudomonas aeruginosa causes life-threatening lung infections in patients with cystic fibrosis. We hypothesized that vaccination may prevent P. infection. In a double-blind, placebo-controlled, multicenter trial, 483 European patients, 2-18 years of age without colonization were randomly assigned to receive four intramuscular injections bivalent flagella vaccine or placebo over 14-month period. Patients evaluated quarterly for aeruginosa-positive throat cultures and antipseudomonal serum...
Abstract Objectives: To study the safety and efficacy of continuous intratympanic dexamethasone‐phosphate (Dex‐P) for severe to profound sudden idiopathic sensorineural hearing (ISSHL) or anacusis after failure systemic therapy. Study Design: Randomized, double‐blind, placebo controlled multicenter trial. Methods: Patients with ISSHL insufficient recovery (mean 4PTA = 97 dB HL) high dose glucocorticoid therapy received either Dex‐P (4mg/ml) (NaCl 0.9%) continuously applied 14 days into round...
Abstract Introduction Sepsis has been identified as a risk factor for human cytomegalovirus (CMV) reactivation in critically ill patients. However, the contribution of CMV on morbidity and mortality is still controversial. Therefore, we analyzed incidence impact outcome patients with severe sepsis. Methods In prospective longitudinal double-blinded observational study, 97 adult nonimmunosuppressed CMV-seropositive new onset sepsis were included. Leukocytes, plasma tracheal secretions...
PURPOSE: To compare first-line high-dose chemotherapy (HD-CT) with autologous blood stem-cell transplantation to standard-dose (SD-CT) in male patients advanced germ cell tumors (GCTs), a matched-pair analysis was performed within homogenous group of classified as having either Indiana disease or poor prognosis according International Germ Cell Cancer Consensus Group (IGCCCG) criteria. PATIENTS AND METHODS: A multivariate that included 147 consecutive who had received sequential cisplatin,...
In patients with Crohn's disease (CD) and ulcerative colitis (UC), medical, sociodemographic, psychologic "risk protective" factors for general health-related life satisfaction (GLS HRLS, respectively)--defined as preference-based judgments of quality life--have not been studied to date.A total 429 868 (49%) outpatients (CD, n = 317; UC, 112) attending 3 tertiary care centers members the German Disease/Ulcerative Colitis Foundation completed sociodemographic medical questionnaires...
<h3>Introduction</h3> Long-term follow-up data on preterm infants with breast milk–acquired postnatal cytomegalovirus (CMV) infection are sparse. <h3>Aim</h3> To systematically evaluate the long-term cognitive outcome and prevalence of cerebral palsy (CP) in patients after CMV infection. <h3>Patients methods</h3> All surviving <1500 g born our centre between 1 June 1995 2000, acquired at up to 3 months corrected age, were eligible for study; this included neurological neurocognitive...
T-cell immunity is central for control of COVID-19, particularly in patients incapable mounting antibody responses. CoVac-1 a peptide-based activator composed SARS-CoV-2 epitopes with documented favorable safety profile and efficacy terms SARS-CoV-2-specific response. We here report Phase I/II open-label trial (NCT04954469) 54 congenital or acquired B-cell deficiency receiving one subcutaneous dose. Immunogenicity CoVac-1-induced responses are the primary secondary endpoints, respectively....
Clinical studies indicate that coronary plaque morphology might be differentiated noninvasively using multislice CT by determining tissue density within the lesions. The aim of present experimental study was to evaluate factors influence measurements small vessels.A phantom model developed, consisting silicon tubes (lumen diameter 4 mm) with two plaques known inside, simulating soft and intermediate lesions (Plaque 1: -39 HU; Plaque 2: 72 HU). Density measurement were conducted in three...
In cystic fibrosis (CF), infection with Burkholderia cepacia complex (Bcc) strains may cause long-term asymptomatic airway colonization, or severe lung leading to rapid pulmonary decline. To assess the virulence of Bcc strains, we established a model in mice null allele gene involved X-linked chronic granulomatous disease (CGD). CGD mice, challenged intratracheally 103 cells epidemic cenocepacia strain J2315, died within 3 days from sepsis after bacteria had multiplied 3.3 × 108 cells....
Hypothesis: Different methods of pure-tone audiometry analysis in sudden hearing loss studies show a lack agreement with respect to outcome, and the choice outcome measure influences sample size calculation. Background: There is an increasing number clinical reports on treatment loss. For comparison efficacy between different therapies for meta-analysis, it important consider measures studies. Statistical used this study. Materials Methods: Controlled therapy idiopathic sensorineural (ISSHL)...
This study examined the frequency and extent of detrimental effects cognitive behavioral therapy (CBT) for psychosis. In a randomized clinical trial, we investigated efficacy CBT reduction negative symptoms as compared with remediation (CR) in schizophrenia patients (n = 198). Safety was addressed through assessment severe adverse events (SAEs), which were defined suicides, suicide attempts, suicidal crises, symptom exacerbations over period 12 months after inclusion study. Monthly...
Today, more than 70% of patients with primary node-negative breast cancer are cured by local therapy alone. Many receive overtreatment adjuvant chemotherapy due to inadequate risk assessment. So far, few clinical trials have prospectively evaluated tumor biology based prognostic factors. Risk assessment a biological algorithm including invasion factors urokinase-type plasminogen activator (uPA) and its inhibitor type 1 (PAI-1) will assess up 35-55% as low-risk thus avoid chemotherapy. In...
BACKGROUND: Systemic glucocorticoids are commonly used for primary therapy of idiopathic sudden sensorineural hearing loss (ISSNHL). However, the comparative effectiveness and risk profiles high-dose over lower-dose regimens remain unknown. METHODS: We randomly assigned patients with greater than or equal to 50 dB within 7 days from onset receive either 5 intravenous prednisolone at 250 mg/d (HD-Pred), oral dexamethasone 40 (HD-Dex), or, as a control, (Pred-Control) 60 followed by tapering...
It has been demonstrated that cognitive behavioural therapy (CBT) a moderate effect on symptom reduction and general well being of patients suffering from psychosis. However, questions regarding the specific efficacy CBT, treatment safety, cost-effectiveness, moderators mediators effects are still major issue. The objective this trial is to investigate whether CBT specifically efficacious in reducing positive symptoms when compared with non-specific supportive (ST) which does not implement...
T cell immunity is key for the control of viral infections including SARS-CoV-2, in particular with regard to immune memory and protection against arising genetic variants.