A5023638355- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Blood Coagulation and Thrombosis Mechanisms
- Social and Intergroup Psychology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Adhesion Molecules Research
- Psychology of Moral and Emotional Judgment
- Cultural Differences and Values
- Fungal and yeast genetics research
- Breast Cancer Treatment Studies
- Monoclonal and Polyclonal Antibodies Research
- Sociology and Education Studies
- HER2/EGFR in Cancer Research
- Plant Virus Research Studies
- Behavioral Health and Interventions
- Mental Health Research Topics
- Personality Traits and Psychology
- Epigenetics and DNA Methylation
- Chemokine receptors and signaling
- Toxin Mechanisms and Immunotoxins
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- S100 Proteins and Annexins
- Cancer Treatment and Pharmacology
- Transgenic Plants and Applications
University of Koblenz and Landau
2015-2024
Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
2024
Klinik Bad Oexen
2024
Technical University of Munich
2013-2023
University of Kaiserslautern
2023
Klinikum rechts der Isar
2010-2022
Universität Koblenz
2013-2022
Saarland University
2012-2021
Munich University of Applied Sciences
2021
Hôpital d'Instruction des Armées Bégin
2021
The differences across cultures in the enforcement of conformity may reflect their specific histories.
Replicability of findings is at the heart any empirical science. The aim this article to move current replicability debate in psychology towards concrete recommendations for improvement. We focus on research practices but also offer guidelines reviewers, editors, journal management, teachers, granting institutions, and university promotion committees, highlighting some emerging existing practical solutions that can facilitate implementation these recommendations. challenges improving...
Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion metastasis. High levels of both uPA PAI-1 are associated with poor prognosis breast cancer patients. To confirm the prognostic value primary cancer, we reanalyzed individual patient data provided by members European Organization for Research Treatment Cancer–Receptor Biomarker Group (EORTC-RBG). Methods: The study included 18 datasets involving 8377 During follow-up (median...
In the present research, authors investigated how individual differences in working memory capacity moderate relative influence of automatic versus controlled precursors on self-regulatory behavior. 2 studies, sexual interest behavior (Study 1) and consumption tempting food 2), attitudes toward temptation had a stronger for individuals who scored low rather than high capacity. Analogous results emerged Study 3 anger expression provoking situation when measure personality trait angriness was...
Latent state–trait (LST) theory is a generalization of classical test designed to take account the fact that psychological measurement does not place in situational vacuum. The basic concepts latent (LST theory) are introduced. core LST consists two decompositions: (a) decomposition any observed score into state and error, (b) trait residual representing and/or interaction effects. states traits defined as special conditional expectations. A on variable expectation an observable Yik given...
Background: Most patients with lymph node-negative breast cancer are cured by locoregional treatment; however, about 30% relapse. Because traditional histomorphologic and clinical factors fail to identify the high-risk who may benefit from adjuvant chemotherapy, other prognostic needed. In a unicenter study, we have found that levels of urokinase-type plasminogen activator (uPA) inhibitor type 1 (PAI-1) in primary tumor predictive disease recurrence. Thus, designed Chemo N0 prospective...
In this target article, we argue that personality processes, structure, and development have to be understood investigated in integrated ways order provide comprehensive responses the key questions of psychology. The psychological processes mechanisms explain concrete behaviour situations should explanation for patterns variation across individuals, over time as well structures observed intra–individual inter–individual differences. Personality structures, defined covariation behaviour,...
Background Neutrophil-platelet adhesion may occur as a consequence of platelet activation. The role this heterotypic in ischemic disorders is poorly understood thus far. Methods and Results Systemic venous blood samples were taken from 25 patients with stable angina pectoris unstable pectoris. Neutrophil activation neutrophil-platelet evaluated by two-color flow cytometry. Patients showed significant increase compared (mean±SEM, 132.1±20.5 versus 29.8±4.7 anti-glycoprotein IIb/IIIa mean...
Extravasation and intravasation of solid malignant tumors is controlled by attachment tumor cells to components the basement membrane extracellular matrix, local proteolysis cell migration. Strong clinical experimental evidence has accumulated that tumor-associated serine protease plasmin, its activator uPA (urokinase-type plasminogen activator), receptor uPA-R (CD87), inhibitors PAI-1 PAI-2 are linked cancer invasion metastasis. In cancer, increase uPA, uPA-R, and/or associated with...
Patients receiving trastuzumab for HER2-overexpressing metastatic breast cancer seem to suffer from an increased risk of brain metastases, even in cases with responsive disease. To evaluate whether is able penetrate the blood-brain barrier, we measured levels serum and cerebrospinal fluid patients metastases cancer. In a pilot study, tumors (HercepTest; Dako, Copenhagen, Denmark) were included. At different time points, using newly developed immunoenzymatic test trastuzumab. Six out eight...
We previously identified in a single-center study 76-gene prognostic signature for lymph node-negative (LNN) breast cancer patients. The aim of this was to validate gene an independent more diverse population LNN patients from multiple institutions.Using custom-designed DNA chips we analyzed the expression 76 genes RNA frozen tumor samples 180 who did not receive adjuvant systemic treatment.In validation, highly informative identifying with distant metastasis within 5 years (hazard ratio,...
Abstract. Scales for justice sensitivity from three perspectives (victim, observer, perpetrator) were developed. A latent state-trait analysis revealed high reliabilities (≈ .95). Trait consistencies .61) twice as large occasion specificities .33). The correlation between observer and perpetrator was much higher than the either one victim sensitivity. Self-related concerns (Machiavellianism, paranoia, suspiciousness, vengeance, jealousy, interpersonal trust) correlated more highly with...
Data from two large longitudinal studies were used to analyze reciprocal relations between self-esteem and depressive symptoms across the adult life span. Study 1 included 1,685 participants aged 18 96 years assessed 4 times over a 9-year period. 2 2,479 88 3 4-year In both studies, cross-lagged regression analyses indicated that low predicted subsequent symptoms, but did not predict levels of self-esteem. This pattern results replicated all age groups, for affective-cognitive somatic...
Clinical laboratory testing for HER2 status in breast cancer tissues is critically important therapeutic decision making. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) a powerful tool investigating proteins through the direct and morphology-driven analysis of tissue sections. We hypothesized that MALDI-IMS may determine directly from tissues. Breast (n = 48) predefined were subjected to MALDI-IMS, protein profiles obtained Protein identification was...
Tumour-infiltrating lymphocytes (TILs) are associated with improved survival in several epithelial cancers. The two chemokines CXCL9 and CXCL10 facilitate chemotactic recruitment of TILs, their intratumoral accumulation is a conceivable way to improve TIL-dependent immune intervention cancer. However, the prognostic impact high-grade serous ovarian cancer (HGSC) largely unknown. One hundred eighty four cases HGSC were immunohistochemically analyzed for CXCL9, CXCL10. TILs assessed using CD3,...
There is an active debate regarding whether the ego depletion effect real. A recent preregistered experiment with Stroop task as depleting and antisaccade outcome found a medium-level size. In current research, we conducted multilab replication of that experiment. Data from 12 labs across globe (N = 1,775) revealed small significant effect, d 0.10. After excluding participants who might have responded randomly during task, size increased to 0.16. By adding informative, unbiased data point...
trans-epoxysuccinyl-L-leucylamino-(4-guanidino)butane; HMW-uPA, high molecular weight form of uPA (enzymatically active)