A5069184702- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Acute Myeloid Leukemia Research
- Colorectal and Anal Carcinomas
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Microbial infections and disease research
- Animal Virus Infections Studies
- Cell death mechanisms and regulation
- vaccines and immunoinformatics approaches
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- NF-κB Signaling Pathways
- School Choice and Performance
- Gastric Cancer Management and Outcomes
- RNA and protein synthesis mechanisms
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Viral gastroenteritis research and epidemiology
Institute of Molecular Biology
2023
Philipps University of Marburg
2023
Deutschen Konsortium für Translationale Krebsforschung
2021
German Cancer Research Center
2021
University of Tübingen
2021
Johns Hopkins University
2007
Abstract T cell immunity is central for the control of viral infections. CoVac-1 a peptide-based vaccine candidate, composed SARS-CoV-2 epitopes derived from various proteins 1,2 , combined with Toll-like receptor 1/2 agonist XS15 emulsified in Montanide ISA51 VG, aiming to induce profound combat COVID-19. Here we conducted phase I open-label trial, recruiting 36 participants aged 18–80 years, who received single subcutaneous vaccination. The primary end point was safety analysed until day...
This article examines the extent to which adequate yearly progress (AYP) is a valid and reliable indicator of improvement in low-performing high schools. For random subsample 202 schools, authors investigate school characteristics federal state policy contexts that influence their AYP status. Logistic regression models reveal strongest predictors status schools are number student subgroups for accountable No Child Left Behind Analysis report card data further paints confusing landscape...
Although treatment options of acute myeloid leukemia (AML) have improved over the recent years, prognosis remains poor. Better understanding molecular mechanisms influencing and predicting efficacy may improve disease control outcome. Here we studied expression, prognostic relevance functional role tumor necrosis factor receptor (TNFR) family member Receptor Activator Nuclear Factor (NF)-κB (RANK) in AML. We conducted an experimental ex vivo study using leukemic cells 54 AML patients....
Abstract SAMD1 (SAM-domain containing protein 1), a CpG island-binding protein, plays pivotal role in the repression of its target genes. Despite significant correlation with outcomes various tumor types, cancer has remained largely unexplored. In this study we focused on pancreatic ductal adenocarcinoma (PDAC) and revealed that acts as repressor genes associated epithelial-mesenchymal transition (EMT). Upon deletion PDAC cells, observed significantly increased migration rates. exerts...
Abstract Acute myeloid leukemia (AML) is the most common form of acute in adults. Untreated, AML leads to death within months after first symptoms. Combinatorial chemotherapy, mostly using a pyrimidine analog together with an anthracycline, made this previously incurable disease medicable, and response remission-inducing chemotherapy strongly correlates patient outcome. Despite advances treatment over recent years, still has poor prognosis average 5-year survival rate 30%. A better...
Abstract T-cell immunity is central for the control of viral infections. CoVac-1 a peptide-based vaccine candidate, composed SARS-CoV-2 epitopes derived from various proteins, combined with toll-like receptor 1/2 agonist XS15 emulsified in Montanide TM ISA51 VG, aiming to induce superior combat COVID-19. We conducted Phase I open-label trial, including 36 participants aged 18 80 years, who received one single subcutaneous CoVAC-1 vaccination. The primary endpoint was safety analyzed until...