A5030475043- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Clinical Laboratory Practices and Quality Control
- Zoonotic diseases and public health
- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- COVID-19 Clinical Research Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Cardiac and Coronary Surgery Techniques
- Bartonella species infections research
- Renal function and acid-base balance
- COVID-19 and healthcare impacts
- Cardiac Fibrosis and Remodeling
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Renin-Angiotensin System Studies
- Travel-related health issues
- Viral Infections and Vectors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Toxoplasma gondii Research Studies
University Hospital in Halle
2013-2024
Martin Luther University Halle-Wittenberg
2013-2024
Wittenberg University
2022
Goethe University Frankfurt
2001-2006
University Hospital Frankfurt
2001-2003
BACKGROUND: Systemic glucocorticoids are commonly used for primary therapy of idiopathic sudden sensorineural hearing loss (ISSNHL). However, the comparative effectiveness and risk profiles high-dose over lower-dose regimens remain unknown. METHODS: We randomly assigned patients with greater than or equal to 50 dB within 7 days from onset receive either 5 intravenous prednisolone at 250 mg/d (HD-Pred), oral dexamethasone 40 (HD-Dex), or, as a control, (Pred-Control) 60 followed by tapering...
Systemic glucocorticosteroids ("steroids") are widely used worldwide as a standard of care for primary therapy idiopathic sudden sensorineural hearing loss (ISSHL). The German ISSHL guideline recommends high-dose steroids without evidence from randomized controlled trials (RCTs) and refers solely to retrospective cohort studies. This RCT aims assess the efficacy (improvement in hearing) safety (especially systemic side effects) versus (standard dose steroids) treatment unilateral ISSHL, when...
Objective: This randomized prospective study was initiated to clarify whether individualized heparin and protamine dosing has immediate effects on hemostatic activation platelet function in adult cardiac surgery. Methods: Sixty adults undergoing elective coronary artery bypass grafting (CABG) were assigned receive (HMS group, n= 29) or a standard dose (ACT n=24). Measures of thrombin generation Multiplate ® (Verum Diagnostica, Munich, Germany) tests performed before after cardiopulmonary...
Background Laboratory quantification of IgG subclasses (Ig GS c) is a well‐established second‐line tool for differential diagnosis immune deficiencies. However, so far there still no internationally approved standard available Ig c, and different assays are prone to produce divergent results. In this study, we evaluated the comparability equivalence two commercially c assays, one being Siemens assay on BN ProSpec analyzer other The Binding Site ( TBS ) Roche cobas c502 analyzer. Methods We...
The data reported here demonstrate that a preparation extracted from nonpathogenic mycobacteria such as Mycobacterium smegmatis and hereafter referred to interphase material protected mice against Ehrlich ascitic carcinoma, L-1210 leukemia, another syngeneic lymphoid leukemia. Furthermore, treated by this were much less susceptible endotoxins than when stimulated BCG (bacillus Calmette-Guerin) or M. cells. Moreover, guinea pigs administered in Freund's incomplete adjuvant showed an increased...
Vitamin D, besides its classical effect on mineral homeostasis and bone remodeling, can also modulate apoptosis. A special form of apoptosis termed eryptosis appears in erythrocytes. Eryptosis is characterized by cell shrinkage, membrane blebbing, phospholipid disorganization associated with diseases such as sepsis, malaria or iron deficiency, impaired microcirculation. To our knowledge, this the first study that linked vitamin D humans. This exploratory cross-sectional trial investigated...
Preservation of function is an important goal during surgical management cochleovestibular schwannomas. We here demonstrate the relief vertigo and preservation all five vestibular receptors after removal intracochlear schwannoma with extension to fundus internal auditory canal. A 61-year-old male a five-year history left-sided deafness, tinnitus, attacks, MRI consistent limited through modiolus canal (IAC) underwent transcanal, transcochlear total tumor and—due cerebrospinal fluid leak from...
Climate change is expected to increase the frequency of extreme weather events, such as extended heat waves and droughts in northern hemisphere. Besides affecting ecosystems worldwide, these changes climate patterns will also affect environmental health human populations. While medical community mostly concerned with negative impact change, there might be some beneficial effects. In this study we used laboratory data from a large university clinic Germany (n = 13 406), test for any...
Objectives Characterization of an in vitro diagnostic zinc assay ( LT ‐ SYS ) on a Roche cobas c502 analyzer and evaluation the influence pre‐analytic factors concentration measurements. Design methods Imprecision, bias, linearity, limit blank (LoB), detection (LoD) were established method comparisons performed based respective CLSI guidelines. The time elapsed until analysis, usage pneumatic tube delivery system PTDS special trace element sample tubes was evaluated as well. Results...
The F2-isoprostane 8-iso-PGF2α (also known as 15-F2t-isoprostane, iPF2α-III, 8-epi PGF2α, 15(S)-8-iso-PGF2α, or 8-Isoprostane), a thromboxane A2 receptor (TP) agonist, stable biomarker of oxidative stress, and risk marker cardiovascular disease, has been proposed to aggravate atherogenesis in genetic mouse models atherosclerotic vascular disease. Moreover, the TP plays an eminent role pathophysiology endothelial dysfunction, atherogenesis, Yet it is unknown, how expressed by cells affects...
Introduction: The measurement of β-hydroxybutyrate (βOHB) concentrations is a corner stone the diagnosis diabetic ketoacidosis and other ketonic states. aim this study was to perform validation peripheral blood βOHB assay (Randox) on Roche cobas c502 analyser establish reference range for validated assay. Materials methods: Precision, linearity limit detection blank (LoD, LoB) were determined according Clinical Laboratory Standards Institute (CLSI) EP05-A3, EP 06-A EP17-A2 guidelines, using...
Blood-Gas Analyzers (BGAs) are commonly used in parallel with central laboratory analyzers (CLAs). Given the often-divergent results between BGAs and CLAs this study aims to: 1. Determine whether measurements of potassium (K), sodium (Na), glucose (Glu), lactate (Lact) total hemoglobin (ctHb) on interchangeable; 2. Establish reference intervals (RIs) for both analyzer systems using an indirect statistical approach.During a one-year period K, Na, Glu, Lact ctHb from 500 arterial blood...
Aims Single measurements of higher levels soluble tumor necrosis factor receptor I (sTNF-R1) have been shown to be associated with increased risk mortality. However, up date, little is known about the underlying temporal dynamics sTNF-R1 concentrations and their relation We aimed characterize effect changes in sTNFR-1 on all-cause cardiovascular mortality, independent from other established factors for including inflammatory markers. Methods used data population based cohort study CARLA...
Purpose: To assess humoral responses longitudinally and cellular immunogenicity following SARS-CoV-2-vaccination in patients with hematologic oncologic malignancies receiving checkpoint-inhibitors. Methods: This prospective multicenter trial of the East-German-Study-Group-for-Hematology-and-Oncology, enrolled 398 adults a two (patients; n = 262) to one (controls; 136) ratio. Pre-vaccination, day 35 (d35), 120 (d120) blood samples were analyzed for anti-spike antibodies d120...
In order to elucidate mechanisms for severe acute respiratory syndrome coronavirus 2 vaccination success in hematological neoplasia, we, herein, provide a comprehensive characterization of the spike-specific T-cell and serological immunity induced 130 patients comparison with 91 healthy controls. We studied 121 distinct subpopulations schemes as putative response predictors. lymphoid malignancies an insufficient immunoglobulin G (IgG) was accompanied by CD4+ function. Compared controls,...
Nucleocapsid gene-positive, envelope gene-negative (N2+/E-) SARS-CoV-2 PCR results obtained with the Cepheid Xpert Xpress assay are an infrequent phenomenon. We assessed validity of N2+/E- cases indirect approach by analyzing their occurrence in relation to overall positive rates and absolute number tests (24,909 samples, collected June 2021 July 2022). Additionally, 3022 samples were analyzed CoV-2-plus August/September 2022. The incidence monthly closely followed frequency (p < 0.001),...
The thromboxane A
Validation of the LT-SYS quantitative in vitro copper assay on a Roche Cobas 8000 c502 analyzer and comparison with BIOMED Mira analyzer.Imprecision bias were quantified at different concentration levels (serum plasma) over 20-day period. Linearity was assessed covering range from 4.08 µmol/L to 33.8 µmol/L. Limit blank (LoB) limit detection (LoD) established based total 120 low-level samples. The method 58 plasma samples.Within-run imprecision ranged 0.7% 1.2% within-laboratory 1.4% 3.3%....